Bacillus coagulans in Combination with Chitooligosaccharides Regulates Gut Microbiota and Ameliorates the DSS-Induced Colitis in Mice

Abstract

Probiotic and prebiotic are believed to be useful in alleviating the inflammatory, thereby resolving or preventing the severity of UC. Spore-forming bacteria Bacillus coagulans show advantages of stability and probiotic effects, being suggested as the important probiotics for UC treatment.

Establishment of an Enteric Inflammation Model in Broiler Chickens by Oral Administration with Dextran Sulfate Sodium

“…Because of the importance of butyrate in intestinal development, we speculated that DSS-mediated changes in the composition and function of gut microbiota, especially lower butyrate-producing bacteria abundance and decreased butyrate concentrations, were the leading causes affecting intestinal development. DSS-induced colitis mice had lower butyrate-producing bacteria abundance and butyrate concentrations than normal mice, as described previously [ 49 , 50 ]. Although we did not investigate the changes of gut microbiota and microbial metabolites caused by oral gavage of DSS in the yellow-feathered broilers, their importance in broilers enteric inflammation led us to hypothesize the potential cause of DSS-induced enteric inflammation [ 51 ].…”

Effects of the probioticBacillus coagulansBC69 on the metabolic and histological alterations induced by a high-sugar and high-fat diet in C57BL/6J mice

“…8 The predicted KEGG enzyme abundance based on PICSRUSt-2 predictive functional profiling. The average abundance of KEGG enzyme abundances is differentially enriched in 4 groups at level 2: (a) KEGG level 2 (data are Z-score-transformed to the relative abundance), (b) KEGG level pickles, 32 and feces 33,34 due to the disease and strain specificity of probiotic potential. 35,36 The probiotic BC69 used in this study was first isolated from thick broad bean sauce, a traditional Chinese microbial fermented bean product from Sichuan province, China.…”

“…Potential probiotic strains of B. coagulans were reported to be isolated from different sources such as dairy products, 27,30,31 pickles, 32 and feces 33,34 due to the disease and strain specificity of probiotic potential. 35,36 The probiotic BC69 used in this study was first isolated from thick broad bean sauce, a traditional Chinese microbial fermented bean product from Sichuan province, China.…”

Lactiplantibacillus plantarum P9 alleviates chronic diarrhea via modulation of gut microbiota and its intestinal metabolites: a double-blind, randomized, placebo-controlled study

“…Paraprevotella xylaniphila, Ruminococcus_A faecicola, and Butyricicoccus_A sp002395695 are SCFA producers, especially butyric acid and acetic acid. These SCFAs are signi cantly reduced in patients with IBD and antibiotic-associated diarrhea 33,34,35,36 . Mediterraneibacter torques, also known as Ruminococcus torques, was positively correlated with intestinal permeability and GI diseases, and it was found to be enriched in the gut microbiota of patients with IBS-D 37,38 .…”