Back Cover Image, Volume 40, Issue 1

Guo, Meichen; Song, Hang; Li, Kai; Ma, Minchao; Liu, Yang; Fu, Qiang; He, Zhonggui

doi:10.1002/med.21605

Cited by 6 publications

(9 citation statements)

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“…When the host-guest inclusion complex formed, adjacent H-H correlation between protons of TPE and 𝛾-CD would affect the chemical shifts of protons. 1 H NMR studies could provide an important insight into the nature of the inclusion between guests and 𝛾-CDs. [39,40] As the 1 H NMR spectrum shown in Figure 1B, when 𝛾-CDs were added into the solution of TPE-PEG with a molar ratio of 𝛾-CD to TPE units at 2:1, the broad peaks of protons in aromatic rings split into multiple peaks along with an increased intensity and a downfield shift.…”

Section: Resultsmentioning

confidence: 99%

“…By far, some methods have been developed to adjust fluorescence, such as changing the solubility of AIE molecules, triggering spatial restriction, and combining with other photophysical processes. [ 1 ] However, aiming at the complicated environment in vivo, developing multiple regulation of fluorescence to achieve multiple purposes (like integration of diagnosis and treatment) remains a challenge.…”

Section: Introductionmentioning

confidence: 99%

“…Fluorescence imaging is a promising visualization tool and possesses the advantages in situ response and facile operation, [1][2][3] especially with development of aggregation-induced emission (AIE) reported by Tang et al in 2001. [4] It has attracted much DOI: 10.1002/macp.202200022 attention and enormous potential applications in biochemistry and luminescent materials, such as in diagnosis, lightharvesting and nanocarrier tracking.…”

Section: Introductionmentioning

confidence: 99%

“…[4] It has attracted much DOI: 10.1002/macp.202200022 attention and enormous potential applications in biochemistry and luminescent materials, such as in diagnosis, lightharvesting and nanocarrier tracking. [1,[5][6][7] Among all these applications, the key point is to regulate fluorescence to finish the diagnosis or theranostics by interacting with analytes. For example, testing the fluorescence variation of AIE molecules by conjugating the substrate of the enzymes to AIE molecules is an effective approach for detecting enzymes.…”

Section: Introductionmentioning

confidence: 99%

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Multiregulation of Aggregation‐Induced Emission (AIE) via a Competitive Host–Guest Recognition and α‐Amylase Hydrolyzing

Cai

Lin

Qiao

et al. 2022

Macro Chemistry & Physics

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The multiregulation of aggregation‐induced emission (AIE) that responds to external stimuli to finish multifunctions has become a focus of interest in biodiagnosis. Host–guest‐ recognition is an efficient strategy to introduce switchable, reversible, and other functional properties into AIE molecules. Herein, an amphiphilic tetraphenylethylene (TPE) derivative TPE‐PEG is prepared via the simple amidation reaction and chosen as an AIE‐based guest polymer. The aggregated state of TPE‐PEG is altered and the fluorescence of TPE‐PEG can be turned off in the presence of γ‐cyclodextrins (γ‐CDs) due to the formation of host–guest complex between TPE units and γ‐CDs. TPE units in the cavities of γ‐CDs are released free and an aggregated state of TPE‐PEG is restored via the guest competition epistasis of bile acid. Meanwhile, α‐amylase can hydrolyze the host molecules of γ‐CDs, resulting in an aggregated state of TPE‐PEG again and turning the fluorescence on subtly. This reversible multiregulation of fluorescence may meet the multirequirements for the diagnosis in vivo due to the biological nature of α‐amylase and bile acid.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Multiregulation of Aggregation‐Induced Emission (AIE) via a Competitive Host–Guest Recognition and α‐Amylase Hydrolyzing

Cai

Lin

Qiao

et al. 2022

Macro Chemistry & Physics

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“…Because of the fascinating photophysical properties, AIEgens are especially promising for biomedical applications [ 35–37 ] Different AIEgens were designed and widely used for cancer diagnosis, cellular organelle staining, monitoring biological processes, detection of biomolecules, bacterial detection, DNA visualization, and so on. [ 38 ] It is important to show that the biomedical applications of AIEgens have been extended from in vitro imaging to in vivo diagnosis as well as image‐guided therapy.…”

Section: The Overview Of Aiementioning

confidence: 99%

Aggregation‐Induced Emission‐Based Platforms for the Treatment of Bacteria, Fungi, and Viruses

Chen

Han

Tang

et al. 2021

Adv Healthcare Materials

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The prevention and control of pathogenic bacteria, fungi, and viruses is a herculean task for all the countries since they greatly threaten global public health. Rapid detection and effective elimination of these pathogens is crucial for the treatment of related diseases. It is urgently demanded to develop new diagnostic and therapeutic strategies to combat bacteria, fungi, and viruses‐induced infections. The emergence of aggregation‐induced emission (AIE) luminogens (AIEgens) is a revolutionary breakthrough for the treatment of many diseases, including pathogenic infections. In this review, the main focus is on the applications of AIEgens for theranostic treatment of pathogenic bacteria, fungi, and viruses. Due to the AIE characteristic, AIEgens are promising fluorescent probes for the detection of bacteria, fungi, and viruses with excellent sensitivity and photostability. Moreover, AIEgen‐based theranostic platforms can be fabricated by introducing bactericidal moieties or designing AIE photosensitizers and AIE photothermal agents. The current strategies and ongoing developments of AIEgens for the treatment of pathogenic bacteria, fungi, and viruses will be discussed in detail.

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Lipophilic AIEgens as the “Trojan Horse” with Discrepant Efficacy in Tracking and Treatment of Mycobacterial Infection

Shi,

Huang,

Wang

et al. 2023

Adv Healthcare Materials

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The highly contagious tuberculosis is a leading infectious killer, which urgently requires effective diagnosis and treatment methods. To address these issues, three lipophilic aggregation‐induced emission (AIE) photosensitizers (TTMN, TTTMN, and MeOTTMN) were selected to evaluate their labeling and antimicrobial properties in vitro and in vivo. These three lipophilic AIEgens preserve low cytotoxicity and achieve real‐time and non‐invasive visualization of the process of mycobacteria infection in vivo and in vitro. More importantly, these AIEgens can be triggered by white light to produce reactive oxygen species (ROS), which is a highly efficient antibacterial reagent. Among these AIEgens, TTMN photosensitizers have an outstanding antibacterial efficacy over the clinical first‐line drug rifampicin at the same therapeutic concentration. Interestingly, this study also finds that TTMN can increase the expression of pro‐inflammatory cytokines in the early stage of infection after light irradiation, indicating an additional pro‐inflammatory role of TTMN. This work provides some feasibility basis for developing AIEgens‐based agents for effectively destroying mycobacterium.This article is protected by copyright. All rights reserved

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Back Cover Image, Volume 40, Issue 1

Abstract: Description of the back cover image: The cover image is based on the REVIEW ARTICLE A new approach to developing diagnostics and therapeutics: aggregation‐induced emission based fluorescence turn‐on by Meichen Guo et al., https://doi.org/10.1002/med.21595.

Cited by 6 publications

References 0 publications

Multiregulation of Aggregation‐Induced Emission (AIE) via a Competitive Host–Guest Recognition and α‐Amylase Hydrolyzing

Multiregulation of Aggregation‐Induced Emission (AIE) via a Competitive Host–Guest Recognition and α‐Amylase Hydrolyzing

Aggregation‐Induced Emission‐Based Platforms for the Treatment of Bacteria, Fungi, and Viruses

Lipophilic AIEgens as the “Trojan Horse” with Discrepant Efficacy in Tracking and Treatment of Mycobacterial Infection

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