Back to Where It Was First Described: Vectors of Sylvatic Yellow Fever Transmission in the 2017 Outbreak in Espírito Santo, Brazil

Stanzani, Luciana Matos de Abreu; Motta, Monique de Albuquerque; Erbisti, Rafael Santos; Abreu, Filipe Vieira Santos de; Nascimento-Pereira, Agostinho Cardoso; Ferreira-de-Brito, Anielly; Neves, Maycon Sebastião Alberto Santos; Pereira, Glaucio Rocha; Pereira, Glauber Rocha; Santos, Claudiney Biral dos; Pinto, Israel de Souza; Vicente, Creuza Rachel; Faccini-Martínez, Álvaro A.; Cavalcante, Karina Ribeiro Leite Jardim; Falqueto, Aloísio; Oliveira, Ricardo Lourenço de

doi:10.3390/v14122805

Cited by 5 publications

(5 citation statements)

References 38 publications

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“…The high density of susceptible NHPs, particularly of the genera Sapajus , Alouatta , and Callithrix , found in areas of the Atlantic Forest, combined with the large distribution, high abundance, and natural infection of the primary vectors, Haemagogus janthinomys / capricornii and Hg. leucocelaenus, was responsible for the re-emergence of sylvatic yellow fever (SYF) in the southeast of Brazil [ 15 , 16 ]. Intense YFV circulation generating mutational changes and promoting the emergence of new virus strains has been described [ 5 , 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Ecological, Genetic, and Phylogenetic Aspects of YFV 2017–2019 Spread in Rio de Janeiro State

Ribeiro

Delatorre

Abreu

et al. 2023

Viruses

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In Brazil, a yellow fever (YF) outbreak was reported in areas considered YF-free for decades. The low vaccination coverage and the increasing forest fragmentation, with the wide distribution of vector mosquitoes, have been related to yellow fever virus (YFV) transmission beyond endemic areas since 2016. Aiming to elucidate the molecular and phylogenetic aspects of YFV spread on a local scale, we generated 43 new YFV genomes sampled from humans, non-human primates (NHP), and primarily, mosquitoes from highly heterogenic areas in 15 localities from Rio de Janeiro (RJ) state during the YFV 2016–2019 outbreak in southeast Brazil. Our analysis revealed that the genetic diversity and spatial distribution of the sylvatic transmission of YFV in RJ originated from at least two introductions and followed two chains of dissemination, here named the YFV RJ-I and YFV RJ-II clades. They moved with similar dispersal speeds from the north to the south of the RJ state in parallel directions, separated by the Serra do Mar Mountain chain, with YFV RJ-I invading the north coast of São Paulo state. The YFV RJ-I clade showed a more significant heterogeneity across the entire polyprotein. The YFV RJ-II clade, with only two amino acid polymorphisms, mapped at NS1 (I1086V), present only in mosquitoes at the same locality and NS4A (I2176V), shared by all YFV clade RJ-II, suggests a recent clustering of YFV isolates collected from different hosts. Our analyses strengthen the role of surveillance, genomic analyses of YVF isolated from other hosts, and environmental studies into the strategies to forecast, control, and prevent yellow fever outbreaks.

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Section: Introductionmentioning

confidence: 99%

Ecological, Genetic, and Phylogenetic Aspects of YFV 2017–2019 Spread in Rio de Janeiro State

Ribeiro

Delatorre

Abreu

et al. 2023

Viruses

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“…Sabethes identicus is a common sylvatic bamboo inhabiting mosquito species, which has been found in Argentina, Bolivia, Brazil, Colombia, French Guiana, Panama, and Costa Rica. It promptly bites humans in the forest [ 9 , 21 , 22 ] and has been recently found naturally infected with YFV [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…soperi Lane & Cerqueira and Sa. identicus Dyar & Knab] have also been found naturally infected with yellow fever virus (YFV) and other arboviruses (e.g., Triniti, Bussuquara, Mucambo, Murutucu, Mayaro, Kairi, Melao, Sororoca, Tucunduba, Xiburema) [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Biological and behavioral features and colonization of the sylvatic mosquito Sabethes identicus (Diptera: Culicidae)

Lima Bersot,

Vieira,

De Moraes

et al. 2023

PLoS ONE

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Mosquitoes of the genus Sabethes are exclusively sylvatic species occurring in Central and South Americas, where they play a role in the transmission of arbovirus. Sabethes identicus, a common bamboo-breeder species, has been found naturally infected with yellow fever virus. Our study aimed to describe biological and behavioral features of Sa. identicus in the laboratory, as well as establish and standardize an isolated colony for experimental assays. We tested different larval densities and evaluated larval and pupal development time, oviposition behavior, egg production, and longevity. We also shot and video-documented bionomics and behavioral aspects of the mosquitoes in the field and laboratory. A colony with more than 30 generations was achieved. Embryogenesis of Sa. identicus is completed in about three days with a 79% hatch rate, while larval and pupal development takes approximately 15–17 and nine days, respectively. The mosquito’s entire life cycle lasts approximately 30 days. Adult females could survive 71 days, and each individual laid an average of 88 eggs over their lifetime; 50% of females and males survived 37 and 24 days, respectively. Hematophagy peaks as early as the first week of emergence. The net content of a bamboo internode influenced the choice for oviposition, with the average number of eggs laid in those containing rearing water with larval and pupal exuviae being significantly higher than when they had only dechlorinated water or water with yeast. We documented for the first time an ecological association of weevils and Sa. identicus, where the oviposition of the latter depends on the weevil creating a hole in the bamboo wall for egg-laying purposes. Video recordings revealed for the first time the peculiar movements of gravid females during egg-throwing into tiny bamboo holes, as well as the laborious escape of newly emerged adults from the bamboo cavity, and mating behavior.

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“…leucocelaenus e Hg. janthinomys/capricornii costumam estar presentes(88,89,90), só foi realizada no período seguinte do pico da epidemia por questões operacionais. sanguíneos, o que restringiu o número de ingurgitadas coletadas nas copas das árvores.…”

unclassified

“…janthinomys/capricornii e Sa. chloropterus(90). O vírus amarílico também foi encontrado em fêmeas de Sa.…”

unclassified

Identificação de culicídeos, fontes sanguíneas e vírus em sequenciamento único por nanoporos durante surto de febre amarela na Serra da Cantareira, São Paulo

Rocha

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Natal Fernandes, por acreditarem em mim e me aceitarem como aluna, mesmo não me conhecendo tão bem no início. Agradeço por todos os ensinamentos, conselhos, confiança, por estarem sempre dispostas a tirar minhas dúvidas e agradeço, principalmente, por toda a paciência que tiveram comigo. Obrigada por não alimentarem o meu pânico e me manterem com a cabeça no lugar todas as vezes que eu me perdia. Isso foi muito importante pra mim. De verdade! Agradeço a Dra. Juliana Telles de Deus, que me orientou durante o aprimoramento profissional e continuou me ajudando durante o mestrado. Obrigada por me abrir para o mundo mágico (mas real) da ciência. Obrigada por todos os conselhos profissionais e pessoais e por todas as conversas profundas que compartilhamos. Obrigada por ser como uma irmã pra mim, puxando a orelha quando necessário, mas sempre com muito carinho e amizade. Agradeço também a Dra. Ester Cerdeira Sabino, por me aceitar no grupo CADDE, por acreditar em mim e por ser essa grande fonte de inspiração para todas as mulheres do laboratório. De fato, eu me sinto muito privilegiada por ter tido como orientadoras mulheres incríveis da ciência. Agradeço aos pesquisadores Dra. Mariza Pereira, Dr. Luis Filipe Mucci e Dr. Eduardo Bergo do Instituto Pasteur (SUCEN, por carinho) por todo conhecimento e experiência passados desde o início da elaboração do projeto Cantareira. Agradeço a Dra. Marcia Bicudo, a Dra. Regiane Maria Tironi de Menezes e ao Aristides Fernandes pela disponibilidade para me passarem um pouco de seu conhecimento em taxonomia e por me fazerem amar passar horas na mesa fria identificando culicídeos. Agradeço a Dra. Jaqueline Goes de Jesus por ensinar tudo sobre sequenciamento por nanoporos e tudo sobre práticas de laboratório molecular. Agradeço também ao Dr. Jeremy Mirza, a Dra. Ingra Morales Claro, ao Ian Nunes e a Pamela dos Santos Andrade por me auxiliarem com tudo durante a adaptação dos protocolos com os mosquitos. Agradeço ao melhor grupo de amigas que eu poderia ter feito durante o mestrado:

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Back to Where It Was First Described: Vectors of Sylvatic Yellow Fever Transmission in the 2017 Outbreak in Espírito Santo, Brazil

Cited by 5 publications

References 38 publications

Ecological, Genetic, and Phylogenetic Aspects of YFV 2017–2019 Spread in Rio de Janeiro State

Ecological, Genetic, and Phylogenetic Aspects of YFV 2017–2019 Spread in Rio de Janeiro State

Biological and behavioral features and colonization of the sylvatic mosquito Sabethes identicus (Diptera: Culicidae)

Identificação de culicídeos, fontes sanguíneas e vírus em sequenciamento único por nanoporos durante surto de febre amarela na Serra da Cantareira, São Paulo

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