Backscattered electron (BSE) imaging of platinum nano-particles dispersed in mesoporous silica

Ikawa, Nobuaki; Yamada, Mitsuhiko; Miyaki, Atsushi; Endo, Akira

doi:10.1039/c0cc00217h

Cited by 6 publications

(5 citation statements)

References 23 publications

(4 reference statements)

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“…The SiO 2 structures uncoated with metal were observed using an S-4800 field emission-SEM at an acceleration voltage of 0.8–2 kV (Hitachi High-Technologies, Japan). For the cross-sectional SEM image, the specimens were milled with a broad ion beam (E-3500, Hitachi High-Technologies) …”

Section: Experimental Sectionmentioning

confidence: 99%

“…For the cross-sectional SEM image, the specimens were milled with a broad ion beam (E-3500, Hitachi High-Technologies). 30 ■ RESULTS AND DISCUSSION Formation of Siloxane/PS−P4VP Complexes. FT-IR spectra of PS−P4VP and the PS−P4VP/siloxane complexes were obtained to investigate the interaction between PS−P4VP and siloxane.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

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Controlled Formation of Silica Structures Using Siloxane/Block Copolymer Complexes Prepared in Various Solvent Mixtures

et al. 2013

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Block copolymers exhibit regularly patterned structures induced by microphase separation. Here we present a method for preparing various particulate silica (SiO2) nanostructures by controlling the microphase separation of block copolymers. In this method, siloxane, a SiO2 precursor, is adsorbed onto poly(4-vinylpyridine) blocks of polystyrene-block-poly(4-vinylpyridine) in solvent mixtures. After siloxane/polymer complexes are coprecipitated via further siloxane polycondensation, the resulting precipitates are heated to remove the polymer. The results of scanning electron microscopy revealed that SiO2 formed various structures including cylindrical, spherical, and lamellar. Different SiO2 nanostructures formed via the microphase separation of siloxane/polymer complexes are prepared simply by varying solvent mixtures without changing the polymer chain. The structural change is interpreted in terms of polymer-solvent interactions and volume fractions in siloxane/polymer complexes.

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Section: Experimental Sectionmentioning

confidence: 99%

Section: ■ Experimental Sectionmentioning

confidence: 99%

Controlled Formation of Silica Structures Using Siloxane/Block Copolymer Complexes Prepared in Various Solvent Mixtures

et al. 2013

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“…The SEM of the biomaterials after drug loading did not show any changes in the biomaterials microstructure and revealed micrometric precipitates of carboplatin, as well as mannitol on the CaPs surface. Backscattered electron analysis was used to highlight the platinum element in different matrices [72][73][74][75]. This technique uses the signal of the elastic interaction between the electron beam and the specimen.…”

Section: Plos Onementioning

confidence: 99%

Crystallization of carboplatin-loaded onto microporous calcium phosphate using high-vacuum method: Characterization and release study

2020

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Drug delivery systems are a new approach to increase therapeutic efficacy and to reduce the side effects of traditional treatments. Calcium phosphates (CaPs) have been studied as drug delivery systems, especially in bone diseases. However, each system has some particularities that depend on the physical and chemical characteristics of the biomaterials and drug interaction. In this work, granulated CaPs were used as a matrix for loading the anticancer drug carboplatin using the high-vacuum method. Five compositions were applied: hydroxyapatite (HA), β-tricalcium phosphate (β-TCP), biphasic HAp 60%/β-TCP 40% (BCP), β-TCP/MgO nanocomposite, and β-TCP/SiO2 nanocomposite. Carboplatin drug in 50, 60, and 70 mg/g was precipitated on the surface of CaPs. Morphological, chemical and surface modifications in the carboplatin-CaPs were investigated by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), backscattered electron microscopy (BSE), X-ray diffraction (XRD), X-ray fluorescence spectroscopy (XRF), Fourier transform infrared (FT-IR), and Raman spectroscopy. The characterization of the CaP-carboplatin biomaterials showed heterogeneous crystalline precipitation of the drug, and no morphological modifications of the CaPs biomaterials. The in vitro release profile of carboplatin from CaPs was evaluated by the ultraviolet-visible (UV-Vis) method. The curves showed a burst release of upon 60% of carboplatin loaded followed by a slow-release of the drug for the time of the study. The results were typical of a low-interaction system and physisorption mechanism. The high-vacuum method permitted to load the high amount of carboplatin drug on the surface of the biomaterials despite the low interaction between carboplatin and CaPs.

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“…The previous research studies have demonstrated that the evaluation of the dispersity of inorganic particles should consider both the secondary sizes of the aggregated particles and the uniformity of the particle distribution. 20,21 To acquire this information, scanning electron microscopy (SEM), 22,23 transmission electron microscopy (TEM) 24,25 and theoretical modeling [26][27][28] have been carried out previously. Disappointingly, SEM and TEM can usually provide two-dimensional observation results from a single plane in the composite materials.…”

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confidence: 99%

Fluorescence quantification of inorganic particle dispersity for anti-aging evaluation of polymer composites

Sun

Tian

et al. 2023

Chem. Commun.

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Backscattered electron (BSE) imaging of platinum nano-particles dispersed in mesoporous silica

Cited by 6 publications

References 23 publications

Controlled Formation of Silica Structures Using Siloxane/Block Copolymer Complexes Prepared in Various Solvent Mixtures

Controlled Formation of Silica Structures Using Siloxane/Block Copolymer Complexes Prepared in Various Solvent Mixtures

Crystallization of carboplatin-loaded onto microporous calcium phosphate using high-vacuum method: Characterization and release study

Fluorescence quantification of inorganic particle dispersity for anti-aging evaluation of polymer composites

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