Baclofen alters flash-evoked potentials in Long–Evans rats

Hetzler, Bruce E.; Ondracek, Janie M.

doi:10.1016/j.pbb.2007.02.020

Cited by 2 publications

(11 citation statements)

References 83 publications

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“…Only components P 24 and P 87 were unaltered by baclofen. This pattern of results is in good agreement with an earlier study from this laboratory examining the dose-dependent effects of baclofen on FEPs (Hetzler & Ondracek, 2007).…”

Section: Discussionsupporting

confidence: 91%

“…FEPs recorded from the SC were depressed by both baclofen and ethanol in the present study, with ethanol depressing all three components studied, and baclofen depressing components P 29 and N 51 . Interestingly, this is the second time we have reported that baclofen does not alter the amplitude of SC component P 38 (see Hetzler & Ondracek, 2007), indicating a lack of involvement of GABA B receptors in the production of this component. Baclofen neither counteracted nor significantly enhanced the effects of ethanol on FEP amplitudes in the SC, suggesting that the two compounds work via separate mechanisms to alter these components.…”

Section: Discussionmentioning

confidence: 57%

“…), diluted in saline. Drug dosages, injection intervals, and testing time following injections were based on prior research (Hetzler & Martin, 2006;Hetzler & Ondracek, 2007).…”

Section: Chemicalsmentioning

confidence: 99%

“…In addition to recording FEPs, body temperature was measured in the present study, since both ethanol and baclofen can produce hypothermia in rodents (Hetzler & Bednarek, 2001;Hetzler & Ondracek, 2007), and such changes in body temperature may then result in secondary changes in evokedpotential parameters (Hetzler, Boyes, Creason, & Dyer, 1988). Finally, since both ethanol and baclofen alter behavior in rats (e.g., Hetzler & Ondracek, 2007;Hilakivi et al, 1984;Mehta & Ticku, 1987), we monitored gross body movement during and after the evoked-potential recording sessions.…”

Section: Introductionmentioning

confidence: 97%

“…Finally, since both ethanol and baclofen alter behavior in rats (e.g., Hetzler & Ondracek, 2007;Hilakivi et al, 1984;Mehta & Ticku, 1987), we monitored gross body movement during and after the evoked-potential recording sessions.…”

Section: Introductionmentioning

confidence: 99%

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Baclofen Does Not Counteract the Acute Effects of Ethanol on Flash-Evoked Potentials in Long-Evans Rats

Hetzler

Ondracek

Becker

2008

International Journal of Neuroscience

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This experiment examined the separate and combined effects of baclofen (5.0 mg/kg, i.p.), a GABA B receptor agonist, and ethanol (2.0 g/kg, i.p.) on flash-evoked potentials (FEPs) recorded from both the visual cortex and superior colliculus (SC) of chronically implanted male Long-Evans rats. In the visual cortex, ethanol significantly decreased the amplitude of positive component P87, but increased P37 and P47. Other component amplitudes were not significantly altered. In contrast, baclofen reduced the amplitude of negative component N31 to such an extent that it became positive. Although P47 was also reduced by baclofen, the amplitude of most other components was increased. Only P24 and P87 were unchanged by baclofen. The combination of baclofen and ethanol resulted in amplitudes very similar to ethanol alone for secondary components P47, N62, and P87, but very similar to baclofen alone for primary component N31 and late components N147 and P230. In the SC, component amplitudes were generally decreased by ethanol, baclofen, and the combination treatment. Latencies of most components in both structures were increased by the drug treatments. Each drug treatment produced significant hypothermia. Locomotor behavior was also altered. These results demonstrate: (1) pharmacological differences between the primary and late components versus the secondary components of the cortical FEP, (2) that baclofen does not counteract significant effects of ethanol on cortical or collicular component amplitudes, and (3) that baclofen enhances N147-P230 amplitude, suggesting reduced cortical arousal.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 57%

“…), diluted in saline. Drug dosages, injection intervals, and testing time following injections were based on prior research (Hetzler & Martin, 2006;Hetzler & Ondracek, 2007).…”

Section: Chemicalsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Baclofen Does Not Counteract the Acute Effects of Ethanol on Flash-Evoked Potentials in Long-Evans Rats

Hetzler

Ondracek

Becker

2008

International Journal of Neuroscience

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Effect of ethanol on the visual‑evoked potential in rat:dynamics of ON and OFF responses

Dulinskas¹,

Buisas²,

Vengeliene³

et al. 2017

Acta Neurobiologiae Experimentalis

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The effect of acute ethanol administration on the flash visual-evoked potential (VEP) was investigated in numerous studies. However, it is still unclear which brain structures are responsible for the differences observed in stimulus onset (ON) and offset (OFF) responses and how these responses are modulated by ethanol. The aim of our study was to investigate the pattern of ON and OFF responses in the visual system, measured as amplitude and latency of each VEP component following acute administration of ethanol. VEPs were recorded at the onset and offset of a 500 ms visual stimulus in anesthetized male Wistar rats. The effect of alcohol on VEP latency and amplitude was measured for one hour after injection of 2 g/kg ethanol dose. Three VEP components-N63, P89 and N143-were analyzed. Our results showed that, except for component N143, ethanol increased the latency of both ON and OFF responses in a similar manner. The latency of N143 during OFF response was not affected by ethanol but its amplitude was reduced. Our study demonstrated that the activation of the visual system during the ON response to a 500 ms visual stimulus is qualitatively different from that during the OFF response. Ethanol interfered with processing of the stimulus duration at the level of the visual cortex and reduced the activation of cortical regions.

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Baclofen alters flash-evoked potentials in Long–Evans rats

Cited by 2 publications

References 83 publications

Baclofen Does Not Counteract the Acute Effects of Ethanol on Flash-Evoked Potentials in Long-Evans Rats

Baclofen Does Not Counteract the Acute Effects of Ethanol on Flash-Evoked Potentials in Long-Evans Rats

Effect of ethanol on the visual‑evoked potential in rat:dynamics of ON and OFF responses

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