Baclofen or nNOS inhibitor affect molecular and behavioral alterations evoked by traumatic spinal cord injury in rat spinal cord

Kisucká, Alexandra; Hricová, Ľudmila; Pavel, Jaroslav; Strosznajder, Joanna B.; Chalimoniuk, Małgorzata; Langfort, Józef; Gálik, Ján; Maršala, Martin; Radonák, J; Lukáčová, Nadežda

doi:10.1016/j.spinee.2014.08.013

Cited by 6 publications

(1 citation statement)

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“…Another approach would be to implant intrathecal minipumps to deliver a drug with a high spatial resolution to specific parts of the spinal cord ( Dableh et al, 2009 ). Surgical interventions, such as spinal transection, can be performed to evaluate the role of the sensorimotor circuitry in vivo without the influence of a descending modulatory control ( Kisucká et al, 2015 ). In addition, interventional approaches enable the study of the correlation of spinal with supraspinal mechanisms ( Watanabe et al, 2015 ).…”

Section: Translation Of Risk Factors Triggering Factors and Pathophys...mentioning

confidence: 99%

Consensus guidelines on the construct validity of rodent models of restless legs syndrome

Salminen

Clemens

Garcı́a-Borreguero³

et al. 2022

Disease Models &Amp; Mechanisms

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Our understanding of the causes and natural course of restless legs syndrome (RLS) is incomplete. The lack of objective diagnostic biomarkers remains a challenge for clinical research and for the development of valid animal models. As a task force of preclinical and clinical scientists, we have previously defined face validity parameters for rodent models of RLS. In this article, we establish new guidelines for the construct validity of RLS rodent models. To do so, we first determined and agreed on the risk, and triggering factors and pathophysiological mechanisms that influence RLS expressivity. We then selected 20 items considered to have sufficient support in the literature, which we grouped by sex and genetic factors, iron-related mechanisms, electrophysiological mechanisms, dopaminergic mechanisms, exposure to medications active in the central nervous system, and others. These factors and biological mechanisms were then translated into rodent bioequivalents deemed to be most appropriate for a rodent model of RLS. We also identified parameters by which to assess and quantify these bioequivalents. Investigating these factors, both individually and in combination, will help to identify their specific roles in the expression of rodent RLS-like phenotypes, which should provide significant translational implications for the diagnosis and treatment of RLS.

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Section: Translation Of Risk Factors Triggering Factors and Pathophys...mentioning

confidence: 99%