Bacopa monnieri extract enhances learning-dependent hippocampal long-term synaptic potentiation

Promsuban, Charkriya; Limsuvan, Suveerawan; Akarasereenont, Pravit; Tilokskulchai, Kanokwan; Tapechum, Sompol; Pakaprot, Narawut

doi:10.1097/wnr.0000000000000862

Cited by 20 publications

(7 citation statements)

References 15 publications

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“… Pipil Shrub Leaves Nervous debility NRE [ 98 ] Piper retrofractum Vahl Choi Climber Leaves Schizophrenia Neurotrophic Activity, Alzheimer’s disease [ 4 , 247 ] Plantaginaceae Bacopa monniera (L.) Wettst. Brammishak Herb Whole plant Brain disorder (mental disorder), (Be), mental peace, insomnia, epilepsy Memory enhance, Alzheimer's disease, neuroprotective [ 91 , 93 , 219 , 248 , 249 ] Scoparia dulcis L. Misridana Subshrub Root, fruit Nerve system disorder Increase memory [ 14 , 88 , 177 , 250 ] Plumbaginaceae Plumbago auriculata Lam. Nil Chita Shrub Root, bark Epilepsy, headache (Ga) NRE [ 127 ] Plumbago rosea L. Lal Chita Shrub Root Paralysis, memory loss NRE [ 88 , 104 ] Poaceae …”

Section: Introductionmentioning

confidence: 99%

Traditional Herbal Medicines Against CNS Disorders from Bangladesh

Uddin

Zidorn

2020

Nat. Prod. Bioprospect.

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The majority of the population in Bangladesh uses traditional plant-based medicines to manage various ailments, including central nervous system (CNS) disorders. This review presents ethnobotanical information and relevant scientific studies on plants used in traditional healthcare for the management of various CNS disorders in Bangladesh. The information on the medicinal plants of Bangladesh effective against CNS disorders published in scientific journals, books, and reports was compiled from different electronic databases using specific key words. The present article provides comprehensive information on a total of 224 medicinal plant species belonging to 81 families used for the treatment of CNS disorders by the various peoples of Bangladesh. In total, we reviewed more than 290 relevant papers. In this study, leaves were found as the most often used plant organ, followed by roots, fruits, whole plants, barks, seeds, stems, rhizomes, and flowers. The Fabaceae family contributes the highest number of used species, followed by Rubiaceae, Lamiaceae, Cucurbitaceae, Vitaceae, Euphorbiaceae, Malvaceae, and Zingiberaceae. The most frequently used species (in decreasing order) are Asparagus racemosus, Centella asiatica, Stephania japonica, Aegle marmelos, Coccinia grandis, Tabernaemontana divaricata, Bacopa monnieri, Abroma augusta, and Scoparia dulcis. This review may serve as a starting point for a rational search for neuroactive natural products against CNS disorders within the Flora of Bangladesh. Graphic Abstract

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Section: Introductionmentioning

confidence: 99%

Traditional Herbal Medicines Against CNS Disorders from Bangladesh

Uddin

Zidorn

2020

Nat. Prod. Bioprospect.

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“…Besides, some experimental research report have depicted that B. monniera ameliorates mental disorder and memory impairment 63,64 . It also enhanced learning‐associated hippocampal long‐acting synaptic potentiation 65 and possesses anti‐convulsant property 66 . Similarly, bacoside‐A protects the brain from neurodegenerative diseases and it possess anti‐depressant and anti‐ageing properties 24,27‐29 .…”

Section: Discussionmentioning

confidence: 99%

Osteogenic differentiation potential of human bone marrow‐derived mesenchymal stem cells enhanced by bacoside‐A

Ramesh

2020

Cell Biochemistry & Function

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Stem cell therapy is growing rapidly to treat numerous diseases including bone‐associated diseases. Mesenchymal stem cells (MSCs) are most commonly preferred to treat bone diseases because it possesses high osteogenic potency. Though, to obtain maximum osteogenic efficiency of MSCs is challenging. Therefore, this study was planned to evaluate the osteogenic efficiency of human bone marrow derived mesenchymal stem cells (hBMSCs) by bacoside‐A. This study was investigated the activity of alkaline phosphatase (ALP) and expressions of the genes specific to osteogenic regulation mainly runt‐related transcription factor 2 (Runx2), osterix (Osx), osteocalcin (OCN) and collagen type Iα1 (Col I α1) in hBMSCs cultured under osteogenic conditions at different concentrations of bacoside‐A for 14 days. The results of this study depicted significant upregulation in the activity of ALP and expressions of osteogenic regulator genes in bacoside‐A treated cells when compared with control cells. Besides, expressions of glycogen synthase kinase‐3β (GSK‐3β) and Wnt/β‐catenin were evaluated; these expressions were also significantly increased in bacoside‐A treated cells when compared with control cells. This result provides a further supporting evidence of bacoside‐A role on osteogenesis in hBMSCs. The present study suggest that bacoside‐A will be applied to ameliorate the process of osteogenesis in hBMSCs to repair damaged bone structure during MSC‐based therapy; this will be an excellent and auspicious treatment for bone‐associated disorders including osteoporosis. Significance of the study Osteoporosis is a bone metabolic disorder characterized by an imbalance between the activity of osteoblastic bone formation and osteoclastic bone resorption that disrupts the bone microarchitecture. Current anti‐osteoporotic drugs are inhibiting bone resorption, but they are unable to restore the bone structure due to extreme bone remodelling process and causes numerous side effects. The finding of natural bioactive compounds with osteogenic property is very essential for osteoporosis treatment. This study was reported that bacoside‐A ameliorated osteogenic differentiation of hBMSCs through upregulation of osteogenic differentiation genes and Wnt/β‐catenin signalling pathway. This result is indicating that bacoside‐A may be useful for osteoporosis treatments.

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“…However, this study found no significant differences in BrdU and/or DCX expression in the hippocampus of naïve (healthy) animals. Furthermore, an electrophysiological study has shown that BME enhances the magnitude of long-term potentiation with the inverted U-shaped dose-effect relationship in healthy animals [30].…”

Section: Discussionmentioning

confidence: 99%

Bacopa monnieri extract improves novel object recognition, cell proliferation, neuroblast differentiation, brain-derived neurotrophic factor, and phosphorylation of cAMP response element-binding protein in the dentate gyrus

et al. 2018

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Bacopa monnieri is a medicinal plant with a long history of use in Ayurveda, especially in the treatment of poor memory and cognitive deficits. In the present study, we hypothesized that Bacopa monnieri extract (BME) can improve memory via increased cell proliferation and neuroblast differentiation in the dentate gyrus. BME was administered to 7-week-old mice once a day for 4 weeks and a novel object recognition memory test was performed. Thereafter, the mice were euthanized followed by immunohistochemistry analysis for Ki67, doublecortin (DCX), and phosphorylated cAMP response element-binding protein (CREB), and western blot analysis of brain-derived neurotrophic factor (BDNF). BME-treated mice showed moderate increases in the exploration of new objects when compared with that of familiar objects, leading to a significant higher discrimination index compared with vehicle-treated mice. Ki67 and DCX immunohistochemistry showed a facilitation of cell proliferation and neuroblast differentiation following the administration of BME in the dentate gyrus. In addition, administration of BME significantly elevated the BDNF protein expression in the hippocampal dentate gyrus, and increased CREB phosphorylation in the dentate gyrus. These data suggest that BME improves novel object recognition by increasing the cell proliferation and neuroblast differentiation in the dentate gyrus, and this may be closely related to elevated levels of BDNF and CREB phosphorylation in the dentate gyrus.

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Bacopa monnieri extract enhances learning-dependent hippocampal long-term synaptic potentiation

Cited by 20 publications

References 15 publications

Traditional Herbal Medicines Against CNS Disorders from Bangladesh

Traditional Herbal Medicines Against CNS Disorders from Bangladesh

Osteogenic differentiation potential of human bone marrow‐derived mesenchymal stem cells enhanced by bacoside‐A

Bacopa monnieri extract improves novel object recognition, cell proliferation, neuroblast differentiation, brain-derived neurotrophic factor, and phosphorylation of cAMP response element-binding protein in the dentate gyrus

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