Bacopa monnieri modulates endogenous cytoplasmic and mitochondrial oxidative markers in prepubertal mice brain

Shinomol, George K.; Muralidhara, .

doi:10.1016/j.phymed.2010.08.005

Cited by 56 publications

(30 citation statements)

References 55 publications

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“…Part of its effect may be explained by its protection against oxidative stress and damage, as demonstrated in several studies (e.g. Jyoti and Sharma, ; Hosamani and Muralidhara, ; Saini et al ., ; Shinomol and Muralidhara, ; Shinomol et al ., ).…”

Section: Discussionmentioning

confidence: 99%

Effects of Five Ayurvedic Herbs on Locomotor Behaviour in a Drosophila melanogaster Parkinson's Disease Model

Jansen

Brogan

Whitworth

et al. 2014

Phytotherapy Research

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Current conventional treatments for Parkinson's disease (PD) are aimed at symptom management, as there is currently no known cure or treatment that can slow down its progression. Ayurveda, the ancient medical system of India, uses a combination of herbs to combat the disease. Herbs commonly used for this purpose are Zandopa (containing Mucuna pruriens), Withania somnifera, Centella asiatica, Sida cordifolia and Bacopa monnieri. In this study, these herbs were tested for their potential ability to improve climbing ability of a fruit fly (Drosophila melanogaster) PD model based on loss of function of phosphatase and tensin-induced putative kinase 1 (PINK1). Fruit flies were cultured on food containing individual herbs or herbal formulations, a combination of all five herbs, levodopa (positive control) or no treatment (negative control). Tests were performed in both PINK1 mutant flies and healthy wild-type (WT) flies. A significant improvement in climbing ability was observed in flies treated with B. monnieri compared with untreated PINK1 mutant flies. However, a significant decrease in climbing ability was observed in WT flies for the same herb. Centella asiatica also significantly decreased climbing ability in WT flies. No significant effects were observed with any of the other herbs in either PINK1 or WT flies compared with untreated flies.

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Section: Discussionmentioning

confidence: 99%

Effects of Five Ayurvedic Herbs on Locomotor Behaviour in a Drosophila melanogaster Parkinson's Disease Model

Jansen

Brogan

Whitworth

et al. 2014

Phytotherapy Research

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“…One of the study has showed that dietary BM supplements leads to a significant protection against neurotoxicant-induced oxidative damage in brain. [43] The study further suggests that due to strong antioxidant effect and protective effect against stress-mediated neuronal dysfunctions BM can be useful in HD treatment.…”

Section: Pathological Features Of Hdmentioning

confidence: 89%

“…[4142] It is used for the treatment of epilepsy, insomnia, anxiety, and as memory enhancer for centuries. [4344]…”

Section: Pathological Features Of Hdmentioning

confidence: 99%

Plants and phytochemicals for Huntington′s disease

2013

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Huntington's disease (HD) is a neurodegenerative disorder characterized by progressive motor dysfunction, including chorea and dystonia, emotional disturbances, memory, and weight loss. The medium spiny neurons of striatum and cortex are mainly effected in HD. Various hypotheses, including molecular genetics, oxidative stress, excitotoxicity, metabolic dysfunction, and mitochondrial impairment have been proposed to explain the pathogenesis of neuronal dysfunction and cell death. Despite no treatment is available to fully stop the progression of the disease, there are treatments available to help control the chorea. The present review deals with brief pathophysiology of the disease, plants and phytochemicals that have shown beneficial effects against HD like symptoms. The literature for the current review was collected using various databases such as Science direct, Pubmed, Scopus, Sci-finder, Google Scholar, and Cochrane database with a defined search strategy.

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“…In the Indian subcontinent, the nootropic herb Bacopa monnieri (local name: Brahmi) is traditionally used as memory enhancer,anxiolytic and in neuropharmacological disorders such as epilepsy (Shinomol and Muralidhara, 2011;Aguiar and Borowski, 2013;Sharma et al, 2013). The neuroprotective effect of B. monnieri was earlier reported against dementia (Saini et al, 2012), memory dysfunction (Dwivedi et al, 2013;Le et al, 2013), AD (Uabunditet al, 2010), Parkinson's disease (PD) (Jadiya et al, 2011) and schizophrenia (Piyabhan et al, 2013).…”

Section: Bacopa Monnieri (L) Wettst (Plantaginaceae)mentioning

confidence: 99%

Neuroprotective therapeutics from botanicals and phytochemicals against Huntington's disease and related neurodegenerative disorders

Dey

De²

2015

Journal of Herbal Medicine

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Bacopa monnieri modulates endogenous cytoplasmic and mitochondrial oxidative markers in prepubertal mice brain

Cited by 56 publications

References 55 publications

Effects of Five Ayurvedic Herbs on Locomotor Behaviour in a Drosophila melanogaster Parkinson's Disease Model

Effects of Five Ayurvedic Herbs on Locomotor Behaviour in a Drosophila melanogaster Parkinson's Disease Model

Plants and phytochemicals for Huntington′s disease

Neuroprotective therapeutics from botanicals and phytochemicals against Huntington's disease and related neurodegenerative disorders

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