Bacopa monnieri reduces Tau aggregation and Tau-mediated toxicity in cells

Dubey, Tushar; Kushawa, Preethi; Thulasiram, Hirekodathakallu V.; Chandrashekar, Madhura; Chinnathambi, Subashchandrabose

doi:10.1016/j.ijbiomac.2023.123171

Cited by 14 publications

(5 citation statements)

References 32 publications

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“…In line with our findings, a recent in vitro study has also shown that BM reduces the pathological GSK‐3β phosphorylation to reduce tau aggregation in Alzheimer's disease. [ 67 ] Thus, chronic BM treatment ameliorates the AD‐associated pathological changes ranging from behavioral to molecular levels by regulating the Wnt/β‐catenin pathway via inhibiting the kinase activity of GSK‐3β.…”

Section: Resultsmentioning

confidence: 99%

Amelioration of Amyloid‐β Induced Alzheimer's Disease by Bacopa monnieri through Modulation of Mitochondrial Dysfunction and GSK‐3β/Wnt/β‐Catenin Signaling

Sushma,

Sahu,

Murugan

et al. 2023

Molecular Nutrition Food Res

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BackgroundAlzheimer's disease (AD) is the most prevalent dementia, affecting a large number of populations. Despite being under scrutiny for decades, an effective therapeutic option is still not available.Methods and resultsThis study explores the therapeutic role of a nootropic herb Bacopa monnieri (BM) in AD‐like pathological conditions produced by injecting preformed amyloid‐β42 (Aβ42) fibril bilaterally into hippocampus of Wistar rats, and ethanolic extract of BM is orally administered for 4 weeks. Assessment of behavioral changes reveals that BM treatment ameliorates Aβ42‐induced cognitive impairment and compromised explorative behavior. Supplementation of BM also reduces oxidative stress biomarkers, proinflammatory cytokines, and cholinesterase activity in the AD rats. Additionally, BM treatment restores Bcl‐2‐associated X protein (Bax)/ B‐cell lymphoma 2 (Bcl‐2) imbalance, increases neurotrophic factors expression, and prevents neurodegeneration validated by quantifying Nissl‐positive hippocampal neurons. Interestingly, BM administration eliminates amyloid plaques in the hippocampal region and normalizes the Aβ42‐induced increase in phospho‐tau and total tau expression. Mechanistic investigations reveal that BM interacts with glycogen synthase kinase (GSK‐3β) and restores Wnt/β‐catenin signaling.ConclusionBM has been used in diet as a nootropic herb for several centuries. This study highlights the anti‐Alzheimer activity of BM from the behavioral to the molecular level by modulating mitochondrial dysfunction, and GSK‐3β mediates the Wnt/β‐catenin signaling pathway.

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Section: Resultsmentioning

confidence: 99%

Amelioration of Amyloid‐β Induced Alzheimer's Disease by Bacopa monnieri through Modulation of Mitochondrial Dysfunction and GSK‐3β/Wnt/β‐Catenin Signaling

Sushma,

Sahu,

Murugan

et al. 2023

Molecular Nutrition Food Res

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“…The treatment also decreased GSK-3β phosphorylation in formaldehyde-stressed cells. The authors of this study pointed out that BM extract can play an important role against Tau phosphorylation and aggregation, which can be helpful in the treatment or prevention of Alzheimer's disease [161].…”

Section: Bm Oxidative Stress Mithocondrial Dysfunction and Apoptosismentioning

confidence: 94%

“…BM amplifies free radical scavenging mechanisms and preserves cells in the hippocampus, prefrontal cortex, and striatum, protecting them against cytotoxicity. Furthermore, it decreases lipoxygenase activity, decreases lipid peroxidation, increases GPX activity, and promotes iron chelation [141,161,197,198].…”

Section: Bm and Neurodegenerative Diseases: Evidence From In Vitro An...mentioning

confidence: 99%

Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review Focused on Inflammation, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis

Valotto Neto,

Reverete de Araujo,

Moretti Junior

et al. 2024

Antioxidants

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The aging of the global population has increased the prevalence of neurodegenerative conditions. Bacopa monnieri (BM), an herb with active compounds, such as bacosides A and B, betulinic acid, loliolide, asiatic acid, and quercetin, demonstrates the potential for brain health. Limited research has been conducted on the therapeutic applications of BM in neurodegenerative conditions. This systematic review aims to project BM’s beneficial role in brain disorders. BM has anti-apoptotic and antioxidant actions and can repair damaged neurons, stimulate kinase activity, restore synaptic function, improve nerve transmission, and increase neuroprotection. The included twenty-two clinical trials demonstrated that BM can reduce Nuclear Factor-κB phosphorylation, improve emotional function, cognitive functions, anhedonia, hyperactivity, sleep routine, depression, attention deficit, learning problems, memory retention, impulsivity, and psychiatric problems. Moreover, BM can reduce the levels of pro-inflammatory biomarkers and oxidative stress. Here, we highlight that BM provides notable therapeutic benefits and can serve as a complementary approach for the care of patients with neurodegenerative conditions associated with brain disorders. This review adds to the growing interest in natural products and their potential therapeutic applications by improving our understanding of the mechanisms underlying cognitive function and neurodegeneration and informing the development of new therapeutic strategies for neurodegenerative diseases.

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“…Bacoside A3: This triterpenoid saponin is the promising target for the treatment of Alzheimer's disease by inhibition of the Acetylcholinesterase [22] .…”

Section: Bioactive Components Bacoside Amentioning

confidence: 99%

An overview of Indian herbs with the potential in the treatment of the Alzheimerrsquo;s disease

Raut,

Joshi,

Waghmare

2024

J Pharmacogn Phytochem

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Alzheimer's disease (AD) is a neurodegenerative condition that severely impairs memory and cognitive function. As the illness worsens, it produces verbal and visuospatial difficulties, as well as behavioural issues like rage, sadness, and indifference. The current treatment for Alzheimer's disease has no known cure, symptomatic relief can retard the progression with memory loss and other symptoms. However, natural remedies have a therapeutic effect on several symptoms of this disease, including dementia and Alzheimer's disease. The current review intends to provide an overview of herbs, such as Shankhpushpi, Brahmi, Pumpkin, Ashwagandha, Almond, Kesar, Sage, Amla, Turmeric and many more that have been documented to have CNS activity with respect to AD and could be used to treat symptoms, slow the development of AD.

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Bacopa monnieri reduces Tau aggregation and Tau-mediated toxicity in cells

Cited by 14 publications

References 32 publications

Amelioration of Amyloid‐β Induced Alzheimer's Disease by Bacopa monnieri through Modulation of Mitochondrial Dysfunction and GSK‐3β/Wnt/β‐Catenin Signaling

Amelioration of Amyloid‐β Induced Alzheimer's Disease by Bacopa monnieri through Modulation of Mitochondrial Dysfunction and GSK‐3β/Wnt/β‐Catenin Signaling

Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review Focused on Inflammation, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis

An overview of Indian herbs with the potential in the treatment of the Alzheimerrsquo;s disease

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