Bacoside A: Role in Cigarette Smoking Induced Changes in Brain

Vani, G.; Kothandapani, Anbarasi; Shyamaladevi, Chennam Srinivasulu

doi:10.1155/2015/286137

Cited by 21 publications

(12 citation statements)

References 172 publications

(166 reference statements)

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“…It is well known that cigarette smoking is an intractable and preventable public health problem. 67 Many previous studies 26,50,56,63,66,68,69 have explored the role of smoking in OAB. Although some studies 26,69 found no relationship between smoking and OAB, other studies 50,63 reported that smoking was a risk factor for the onset of OAB.…”

Section: Discussionmentioning

confidence: 99%

Associations Between Risk Factors and Overactive Bladder: A Meta-analysis

Zhu

Dong

et al. 2019

Female Pelvic Med Reconstr Surg

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This meta-analysis suggests that age and body mass index are associated with increased risks of OAB, whereas employment status is associated with a decreased risk of OAB. Further prospective studies with large sample sizes are needed to confirm this conclusion.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Section: Discussionmentioning

confidence: 99%

Associations Between Risk Factors and Overactive Bladder: A Meta-analysis

Zhu

Dong

et al. 2019

Female Pelvic Med Reconstr Surg

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“…Autonomic imbalance is not just associated with cardiovascular disease, but with myriad CNS disorders such as Parkinson's Disease (Haapaniemi et al, 2001), Fragile X syndrome (Boccia and Roberts, 2000), and depression (Agelink et al, 2001). Furthermore, recent studies suggested that air pollution, including SHS, is linked to CNS disorders and neurodegenerative diseases (Calderon-Garciduenas et al, 2015;Vani et al, 2015;Kim et al, 2020;Shabani, 2021). Reducing SHS exposure in non-smokers with smoke-free policies in public venues could have a broader benefit to public health beyond pulmonary and cardiovascular consequences.…”

Section: Perspectivementioning

confidence: 99%

Secondhand Smoke Decreased Excitability and Altered Action Potential Characteristics of Cardiac Vagal Neurons in Mice

et al. 2021

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Background: Secondhand smoke (SHS), a major indoor pollutant, is a significant risk factor for cardiovascular morbidity and mortality including arrhythmias and sudden cardiac death. Exposure to SHS can produce autonomic imbalance, as evidenced by reduced heart rate variability (HRV)—a clinical metric of cardiac vagal regulation. Currently, the mechanisms through which SHS changes the vagal preganglionic neuronal inputs to the heart to produce this remains unknown.Objectives: To characterize the effect of SHS on both the excitability and action potential (AP) characteristics of anatomically identified cardiac vagal neurons (CVNs) in the nucleus ambiguus and examine whether SHS alters small conductance calcium-activated potassium (SK) channel activity of these CVNs.Methods: Adult male mice were exposed to four weeks of filtered air or SHS (3 mg/m3) 6 h/day, 5 day/week. Using patch-clamp recordings on identified CVNs in brainstem slices, we determined neuronal excitability and AP characteristics with depolarizing step- and ramp-current injections.Results: Four weeks of SHS exposure reduced spiking responses to depolarizing current injections and increased AP voltage threshold in CVNs. Perfusion with apamin (20 nM) magnified these SHS-induced effects, suggesting reduced SK channel activity may serve to minimize the SHS-induced decreases in CVNs excitability. Medium afterhyperpolarization (a measurement of SK channel activity) was smaller in the SHS group, further supporting a lower SK channel activity. AP amplitude, rise rate, fast afterhyperpolarization amplitude (a measurement of voltage-gated channel activity), and decay rate were higher in the SHS group at membrane voltages more positive to 0 mV, suggesting altered inactivation properties of voltage-dependent channels underlying APs.Discussion: SHS exposure reduced neuronal excitability of CVNs with compensatory attenuation of SK channel activity and altered AP characteristics. Neuroplasticity of CVNs could blunt regulatory cardiac vagal signaling and contribute to the cardiovascular consequences associated with SHS exposure, including reduced HRV.

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“…Besides, Vani et al. (2015) reported increased Purkinje cells and activated microglia and astrocytes in neural parenchyma of CS‐exposed rats. In the present study, citalopram showed protective influence with mild neural congestion.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective effects of Olea europaea L. fruit extract against cigarette smoke‐induced depressive‐like behaviors in Sprague–Dawley rats

et al. 2021

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Depression is broadly acclaimed as a mental health anomaly and despite advancements in the development of antidepressant drugs, they are linked with side effects. Dietary modifications and medicinal plants like olives can be used as effective strategies due to their antioxidant, immune‐modulatory, antiinflammatory, and anticonvulsant properties. Considering the compositional alterations in olive fruits during ripening, the antidepressant potential of olive fruits at different degrees of ripeness, that is, un‐ripened (green) and ripened (black) was investigated. Rats were randomly divided into five groups: G0 (Normal diet), G1 (Normal diet + smoke exposure (SE), G2 (Normal diet + SE + Citalopram), G3 (Normal diet + SE + Green olive extract), and G4 (Normal diet + SE + Black olive extract). Depressive‐like behaviors were induced in all groups through cigarette smoke exposure except G0. Green and black olive extracts prevented depressive behaviors by reducing the immobility time of rats in forced swim test and tail suspension test while increased the latency to respond in hot plate assay. Moreover, lipid peroxidation in brain tissue was reduced with citalopram, green, and black olive extracts. Additionally, treatments also enhanced the antioxidant pool of brain tissues. Histological examination revealed that olive extracts and citalopram prevented cigarette smoke‐induced moderate to severe necrosis and congestion in the brain parenchyma and elucidated antidepressant potential by improving the expression of monoamine oxidase‐A, solute carrier family 6 member 4, and brain‐derived neurotrophic factor genes. Conclusively, olives may act as a promising antidepressant agent in ameliorating cigarette smoke‐induced depressive‐like behaviors. Practical applications Olive extracts at both ripening stages revealed an antidepressant‐like effect almost similar to the standard antidepressant drug and also prevented oxidative damages. Therefore, from the current findings, it can be recommended that food ingredients with antidepressant potential like olives should be incorporated in future interventions to combat depression/psychiatric anomalies and diet therapy should be encouraged to alleviate lifestyle‐related disorders.

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Bacoside A: Role in Cigarette Smoking Induced Changes in Brain

Cited by 21 publications

References 172 publications

Associations Between Risk Factors and Overactive Bladder: A Meta-analysis

Associations Between Risk Factors and Overactive Bladder: A Meta-analysis

Secondhand Smoke Decreased Excitability and Altered Action Potential Characteristics of Cardiac Vagal Neurons in Mice

Neuroprotective effects of Olea europaea L. fruit extract against cigarette smoke‐induced depressive‐like behaviors in Sprague–Dawley rats

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