Bacteremia caused by Veillonella dispar in an oncological patient

Cobo, Fernando; Pérez-Carrasco, Virginia; García‐Salcedo, José A.; Navarro-Marí, José María

doi:10.1016/j.anaerobe.2020.102285

Cited by 19 publications

(14 citation statements)

References 15 publications

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“…rectale, R. intestinalis, R. hominis, V. atypical, R. gnavus, and L. salivarius, which were consistent with previous research (35). Our data then showed that 4 weeks of lactitol supplementation lead to decrease of cirrhosis-enriched species including pathogenic K. pneumonia (36) and V. dispar (37,38), and increase of some health-beneficial species including B. longum, B. pseudocatenulatum, L. salivarius and B. ovatus (39). Previous studies have also demonstrated that lactitol increased the abundance of the first two species in the gut (11).…”

Section: Discussionsupporting

confidence: 92%

Lactitol Supplementation Modulates Intestinal Microbiome in Liver Cirrhotic Patients

et al. 2021

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Background: Cirrhosis is a common chronic liver disease characterized by irreversible diffuse liver damage. Intestinal microbiome dysbiosis and metabolite dysfunction contribute to the development of cirrhosis. Lactitol (4-β-D-galactopyranosyl-D-glucitol) was previously reported to promote the growth of intestinal Bifidobacteria. However, the effect of lactitol on the intestinal microbiome and fecal short-chain fatty acids (SCFAs) and bile acids (BAs) and the interactions among these factors in cirrhotic patients pre- and post-lactitol treatment remain poorly understood.Methods: Here, using shotgun metagenomics and targeted metabolomics methods.Results: we found that health-promoting lactic acid bacteria, including Bifidobacterium longum, B.pseudocatenulatum, and Lactobacillus salivarius, were increased after lactitol intervention, and significant decrease of pathogen Klebsiella pneumonia and associated antibiotic resistant genes /virulence factors. Functionally, pathways including Pseudomonas aeruginosa biofilm formation, endotoxin biosynthesis, and horizontal transfer of pathogenic genes were decreased in cirrhotic patients after 4-week lactitol intervention compared with before treatment.Conclusion: We identified lactitol-associated metagenomic changes, and provide insight into the understanding of the roles of lactitol in modulating gut microbiome in cirrhotic patients.

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Section: Discussionsupporting

confidence: 92%

Lactitol Supplementation Modulates Intestinal Microbiome in Liver Cirrhotic Patients

et al. 2021

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“…In particular, 2 of the 3 top predictors ( Veillonella dispar and Veillonella infantium ) as well as 2 other species associated with ongoing symptomatic COVID-19 belong to the genus Veillonella . Members of this genus are gram-negative anaerobic coccus that can cause infection in humans ( 30 ). Specifically, V .…”

Section: Resultsmentioning

confidence: 99%

“…In particular, two of the three top predictors (Veillonella dispar and Veillonella infantium) as well as 2 other species associated with ongoing symptomatic COVID-19 disease belong the genus Veillonella. Members of this genus are gram-negative anaerobic coccus that can cause infection in humans (30). Specifically, V. infantium has been found in the bronchoalveolar lavage fluid of the COVID-19 patients suggesting it is a significant co-infectious agent (31).…”

Section: Oral Microbiome Composition Predicts Ongoing Symptomatic Covid-19mentioning

confidence: 99%

Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long COVID

Haran¹,

Bradley²,

Zeamer³

et al. 2021

JCI Insight

120

109

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the pandemic Coronavirus Disease 2019 and now many face the burden of prolonged symptoms-long-lasting COVID-19 symptoms or "long-COVID". Long-COVID is thought to be linked to immune dysregulation due to harmful inflammation, with the exact causes being unknown. Given the role of the microbiome in mediating inflammation, we aimed to examine the relationship between the oral microbiome and the duration of long-COVID symptoms. Tongue swabs were collected from patients presenting with symptoms concerning for COVID-19. Confirmed infections were followed until resolution of all symptoms. Bacterial composition was determined by metagenomic sequencing. We used random forest modeling to identify microbiota and clinical covariates that associated with long-COVID symptoms. Of the patients followed, 63% (17/27) developed ongoing symptomatic COVID-19 and 37% (10/27) went on to long-COVID. Patients with prolonged symptoms had significantly higher abundances of microbiota that induce inflammation, such as members of the genera Prevotella and Veillonella. Of note are species that produce lipopolysaccharides and the similarity of long-COVID patients' oral microbiome to those of patients with chronic fatigue syndrome. All together, we our findings suggest an association with the oral microbiome and long-COVID revealing the possibility that dysfunction of the oral microbiome may contribute to this draining disease.

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“…Furthermore, Karl et al [49] showed that greater microbiota alpha diversity is not always related to gut health but may be associated with the growth of potentially harmful bacteria. This is supported by an increased abundance of the potentially pathogenic genus Veillonella [64,[66][67][68] in the gut of marathon runners [40,46,53]. Although Sheiman et al observed an increase in Veillonella relative abundance in marathon runners post-marathon and isolated a strain of Veillonella atypica from stool samples.…”

Section: Diversity Of the Human Gut Microbiotamentioning

confidence: 99%

Physical activity induced alterations of gut microbiota in humans: a systematic review

Dziewiecka

Buttar

Kasperska

et al. 2022

BMC Sports Sci Med Rehabil

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Background Gut microbiota is considered to have a great impact on human health and disease. While it is widely recognized that the gut microbiota of healthy individuals differs from those with obesity, inflammatory bowel disease, metabolic syndrome, and other chronic diseases, the alterations of gut microbiota with physical activity are not fully understood. Accordingly, we performed this systematic review to address the question regarding the effects of mild and intense exercise on the gut microbiota in humans. Methods The comparative analyses of gut microbiota were conducted following the PRISMA protocol to determine the differences in the active vs. non-active individuals (phenotypes) (n = 11), including the influence of physical activity intervention on the human gut microbiota (n = 13); the differences in the gut microbiota of athletes vs. non-athletes (n = 8); and the microbiota status at different stages of athletic performance or intervention (n = 7), with various of physical activities, sport disciplines, and activity duration. Literature searches were completed using four databases: PubMed, Web of Science, Scopus, and EBSCO, and 2090 articles were retrieved by using appropriate keywords. The low heterogeneity of the studies hasn’t allowed us to prepare a meta-analysis. After excluding 2052 articles, we ultimately selected 38 articles that met the eligibility criteria for this review. Results The data analyses revealed that in non-athletes rising physical activity markedly influenced the relative abundance of short-chain fatty acid (SCFA). Aerobic training that lasted 60 min, and physical activity that characterized 60% HRmax or more also influenced beta diversity indexes. The results showed that athletes harbor a more diverse type of intestinal microflora than non-athletes, but with a relatively reduced abundance of SCFA- and lactic acid-producing bacteria, thereby suggesting an adverse effect of intense exercise on the population of gut microbiota. Conclusion It is concluded that the level of physical activity modulates the gastrointestinal microbiota in humans. For a long period, increasing the intensity and volume of exercise may lead to gut dysbiosis. Perhaps, proper supplementation should be considered to keep gut microbiota in large biodiversity and richness, especially under unfavorable gut conditions associated with intense exercise. Trial registration Prospero CRD42021264064.

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Bacteremia caused by Veillonella dispar in an oncological patient

Cited by 19 publications

References 15 publications

Lactitol Supplementation Modulates Intestinal Microbiome in Liver Cirrhotic Patients

Lactitol Supplementation Modulates Intestinal Microbiome in Liver Cirrhotic Patients

Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long COVID

Physical activity induced alterations of gut microbiota in humans: a systematic review

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