Bacteria and tumor: Understanding the roles of bacteria in tumor genesis and immunology

Zhao, Mingming; Chen, Xiaoxuan; Yang, Zhou; Yang, Xiaodong; Peng, Qiang

doi:10.1016/j.micres.2022.127082

Cited by 15 publications

(4 citation statements)

References 124 publications

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“…39 Bacteria therapy has emerged as a pivotal element in tumor immunotherapy, playing a substantial role in the prevention and treatment of colon cancer. 40,41 As a second-generation probiotic, Pd not only reduces obesity, relieves colitis and type 2 diabetes, but also has significant inhibitory effects on colon cancer. 7 The Pd-OMVs, containing biological components of Pd, raises the intriguing hypothesis that these vesicles may exhibit the same colon tumor inhibitory effects as Pd.…”

Section: Discussionmentioning

confidence: 99%

Parabacteroides distasonis-Derived Outer Membrane Vesicles Enhance Antitumor Immunity Against Colon Tumors by Modulating CXCL10 and CD8+ T Cells

Liang,

Li,

Yang

et al. 2024

DDDT

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Given the potent immunostimulatory effects of bacterial outer membrane vesicles (OMVs) and the significant anti-colon tumor properties of Parabacteroides distasonis (Pd), this study aimed to elucidate the role and potential mechanisms of Pd-derived OMVs (Pd-OMVs) against colon cancer. Methods: This study isolated and purified Pd-OMVs from Pd cultures and assessed their characteristics. The effects of Pd-OMVs on CT26 cell uptake, proliferation, and invasion were investigated in vitro. In vivo, a CT26 colon tumor model was used to investigate the anti-colon tumor effects and underlying mechanisms of Pd-OMVs. Finally, we evaluated the biosafety of Pd-OMVs. Results: Purified Pd-OMVs had a uniform cup-shaped structure with an average size of 165.5 nm and a zeta potential of approximately −9.56 mV, and their proteins were associated with pathways related to immunity and apoptosis. In vitro experiments demonstrated that CT26 cells internalized the Pd-OMVs, resulting in a significant decrease in their proliferation and invasion abilities. Further in vivo studies confirmed the accumulation of Pd-OMVs in tumor tissues, which significantly inhibited the growth of colon tumors. Mechanistically, Pd-OMVs increased the expression of CXCL10, promoting infiltration of CD8 + T cells into tumor tissues and expression of pro-inflammatory factors TNF-α, IL-1β, and IL-6. Notably, Pd-OMVs demonstrated a high level of biosafety. Conclusion: This paper elucidates that Pd-OMVs can exert significant anti-colon tumor effects by upregulating the expression of the chemokine CXCL10, thereby increasing the infiltration of CD8 + T cells into tumors and enhancing antitumor immune responses. This suggests that Pd-OMVs may be developed as a novel nanoscale potent immunostimulant with great potential for application in tumor immunotherapy. As well as developed as a novel nano-delivery carrier for combination with other antitumor drugs.

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Section: Discussionmentioning

confidence: 99%

Parabacteroides distasonis-Derived Outer Membrane Vesicles Enhance Antitumor Immunity Against Colon Tumors by Modulating CXCL10 and CD8+ T Cells

Liang,

Li,

Yang

et al. 2024

DDDT

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“…In recent years, more and more studies have focused on the regulatory effect of microflora on host immunity. Researchers often associate tumor immunology with microbiota [ 15 ], especially non-pathogenic microbiota, which is often not the direct cause of some diseases, but affects local and distant pathological processes, among which gut microbiota has a complex and critical interaction mechanism with the immune system. The gut microbiota helps the immune system tolerate foreign antigens from food; furthermore, it helps the immune system recognize and eliminate pathogenic bacteria, thereby preventing the invasion of pathogens [ 16 ].…”

Section: Gut Microbiota Play a Role In The Development And Progressio...mentioning

confidence: 99%

Potential effects of gut microbiota on host cancers: focus on immunity, DNA damage, cellular pathways, and anticancer therapy

Sun

Feng

2023

The ISME Journal

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The symbiotic bacteria that live in the human gut and the metabolites they produce have long influenced local and systemic physiological and pathological processes of the host. The gut microbiota are increasingly being recognized for its impact on a range of human diseases, including cancer, it may play a key role in the occurrence, progression, treatment, and prognosis of many types of cancer. Understanding the functional role of the gut microbiota in cancer is crucial for the development of the era of personalized medicine. Here, we review recent advances in research and summarize the important associations and clear experimental evidence for the role of the gut microbiota in a variety of human cancers, focus on the application and possible challenges associated with the gut microbiota in antitumor therapy. In conclusion, our research demonstrated the multifaceted mechanisms of gut microbiota affecting human cancer and provides directions and ideas for future clinical research.

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“…In particular, the effect of bacteria on tumor immunity. Bacteria can suppress the function of the immune system through a variety of mechanisms, and some bacteria(such as E. coli , Salmonella , Clostridium butyricum , Listeria ) can enhance immunity and inhibit tumor progression ( 42 ).…”

Section: Effect Of Immunotherapy On Microbial Diversity In Tmementioning

confidence: 99%

Effects of chemotherapy and immunotherapy on microbial diversity in TME and engineered bacterial-mediated tumor therapy

Zheng

Chen

et al. 2023

Front. Immunol.

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Tumor microbiota is a group of microorganisms located in tumor tissues with rich diversity that can promote tumorigenesis and development, and different types of tumors have different tumor microbiotas, which has important implications for tumor research, detection, and clinical treatment. In this review, we examine the diversity of the tumor microbiota, discuss the impact of chemotherapy and immunotherapy on tumor microbiota diversity, and summarize recent advances in the use of genetically engineered bacteria for the treatment of tumors. In addition, we propose key questions that need to be further addressed by the tumor microbiota.

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Bacteria and tumor: Understanding the roles of bacteria in tumor genesis and immunology

Cited by 15 publications

References 124 publications

Parabacteroides distasonis-Derived Outer Membrane Vesicles Enhance Antitumor Immunity Against Colon Tumors by Modulating CXCL10 and CD8+ T Cells

Parabacteroides distasonis-Derived Outer Membrane Vesicles Enhance Antitumor Immunity Against Colon Tumors by Modulating CXCL10 and CD8+ T Cells

Potential effects of gut microbiota on host cancers: focus on immunity, DNA damage, cellular pathways, and anticancer therapy

Effects of chemotherapy and immunotherapy on microbial diversity in TME and engineered bacterial-mediated tumor therapy

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