Bacteria From Marine Sponges: A Source of New Drugs

Bibi, Fehmida; Faheem, Muhammad; Azhar, Esam I.; Yasir, Muhammad; Alvi, Sana; Kamal, Mohammad Azhar; Ullah, Ikram; Naseer, Muhammad Imran

doi:10.2174/1389200217666161013090610

Cited by 65 publications

(48 citation statements)

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“…Illustrative of the importance of symbionts to marine drug discovery, some of these anti-tumorigenic compounds are now suspected to originate from the marine invertebrates symbiotic bacteria, rather than the host itself [8,19,34]. For example, this is true of the anti-tumorigenic drug Yondelis ® (Figrue 1), approved in 2007 for the treatment of ovarian cancer and tissue sarcomas [62].…”

Section: Yondelis ® Smenamides and Smenothiazoles: Compounds With mentioning

confidence: 99%

“…Those microbes which have formed symbiotic relationships with a marine invertebrate, like a sponge or coral, have often developed further secondary metabolites, which also protect their hosts from pathogens [86,87]. This combination of self and host protection has selected for a huge range of secondary metabolites isolated from marine symbionts that are reported to have anti-microbial or anti-pathogenic properties [8,19].…”

Section: Yondelis ® Smenamides and Smenothiazoles: Compounds With mentioning

confidence: 99%

“…Also from sponge-associated actinomycete bacteria the molecule kocurin (Figure 1), a new member of the thiazolyl peptide family of antibiotics, has been isolated from strains in the family Microccocaceae [19]. In their 2013 study Palomo et al isolated 44 Microccocaceae strains from sponges collected in the Florida Keys, and off the coast of Fort Lauderdale and Maryland in the USA.…”

Section: Yondelis ® Smenamides and Smenothiazoles: Compounds With mentioning

confidence: 99%

“…The Phylum Proteobacteria is the second largest group producing bioactive metabolites associated with sponges after the Actinobacteria (discussed above) [19]. For example, norharman (a β-carboline alkaloid) is an anti-microbial metabolite (Figure 1), isolated from strains of the bacteria Pseudoalteromonas piscicida which have been shown to be associated with the sponge Hymeniacidon perleve [57].…”

Section: Yondelis ® Smenamides and Smenothiazoles: Compounds With mentioning

confidence: 99%

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Symbiotic Microbes from Marine Invertebrates: Driving a New Era of Natural Product Drug Discovery

et al. 2017

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Abstract:Invertebrates account for more than 89% of all extant organisms in the marine environment, represented by over 174,600 species (recorded to date). Such diversity is mirrored in (or more likely increased by) the microbial symbionts associated with this group and in the marine natural products (or MNPs) that they produce. Since the early 1950s over 20,000 MNPs have been discovered, including compounds produced by symbiotic bacteria, and the chemical diversity of compounds produced from marine sources has led to them being referred to as "blue gold" in the search for new drugs. For example, 80% of novel antibiotics stemming from the marine environment have come from Actinomycetes, many of which can be found associated with marine sponges, and compounds with anti-tumorigenic and anti-diabetic potential have also been isolated from marine symbionts. In fact, it has been estimated that marine sources formed the basis of over 50% of FDA-approved drugs between 1981 and2002. In this review, we explore the diversity of marine microbial symbionts by examining their use as the producers of novel pharmaceutical actives, together with a discussion of the opportunities and constraints offered by "blue gold" drug discovery.

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Section: Yondelis ® Smenamides and Smenothiazoles: Compounds With mentioning

confidence: 99%

Section: Yondelis ® Smenamides and Smenothiazoles: Compounds With mentioning

confidence: 99%

Section: Yondelis ® Smenamides and Smenothiazoles: Compounds With mentioning

confidence: 99%

Section: Yondelis ® Smenamides and Smenothiazoles: Compounds With mentioning

confidence: 99%

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Symbiotic Microbes from Marine Invertebrates: Driving a New Era of Natural Product Drug Discovery

et al. 2017

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“…Nowadays, marine sponges represent a new and very exciting biotechnology approach to explore a large reservoir of secondary metabolites and associated bacterial communities that produce biomolecules with important applications in health and industry (Bibi et al 2017, Calcabrini et al 2017. Considering the biological diversity of sponges existing in the Brazilian coast (Van Soest et al 2012), the potential for discovery of new molecules for health and industry is very large, and this aspect is explored in the manuscript of Araújo et al (2017) by studying the bacterial communities present in three marine sponges species collected in the coast of Rio de Janeiro, Brazil.…”

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confidence: 99%

Landslide hazard mapping, DNA damage induced by sucrose and the biotechnology potential of sponge-associated bacteria communities

Bonatto

2017

An. Acad. Bras. Ciênc.

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Since its foundation in 1929, the major concern of Annals of The Brazilian Academy of Sciences (AABC) has been to promote scientific investigations in different research fields that could improve the welfare of our populations. In fact, the current number of AABC clearly displays this long-standing editorial tradition.The growth of population in a worldwide scale and the social vulnerability of different human communities subjected to war, economy collapse, ethnical persecution and poverty impose a strong pressure to occupy multi-hazard environments, like flood plains and hill slopes subject to landslides (Sullivan-Wiley and Gianotti 2017). As human communities occupy unstable hill slope areas, activities like deforestation or irregular building sites increase the probability of landslide occurrence (Dai et al. 2002). Thus, it becomes imperative to assess the regional factors that could trigger a landslide event. The manuscript of Cerri et al.(2017) invokes a new geologic strategy to evaluate potential landslide regions in Serra do Mar based on soil fractures and foliation, and the slope geometry of the area. This method could improve the diagnostic of hazard in hill slope areas and directly impact the development of a framework for safe hill slope use for agricultural and urban purposes.Carbohydrate consumption is a major public health concern nowadays, since it represents a large percentage of total energy intake in adults and children worldwide (Azaïs-Braesco et al. 2017, Wittekind andWalton 2014). Despite the development of nutritional guidelines that promotes the reduction of sugars in industrial processed foods, there are evidences that high sucrose western diets are linked to metabolic syndrome (Zhou et al. 2014), nonalcoholic fatty liver disease (Ishimoto et al. 2013), and cardiometabolic disease (DiNicolantonio and Lucan 2014). Unfortunately, the molecular effects of a high sucrose diet are less understood. Early efforts to understand the effects of carbohydrate metabolism and DNA damage were made using Saccharomyces cerevisiae as a model and a systems biology approach (Barea and Bonatto 2008), showing that reactive carbonyl species (RCS) provided by sugar metabolism could be linked to DNA damage. The manuscript of Franke et al. (2017) also addresses this question, and shows that the consumption of a high sucrose diet in rat model promotes DNA damage in hippocampus hence it contributes to the development of diabetes-associated neuropathologies.

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Marine microbial bioprospecting: Exploitation of marine biodiversity towards biotechnological applications—a review

et al. 2022

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The increase in the human population causes an increase in the demand for nutritional supplies and energy resources. Thus, the novel, natural, and renewable resources became of great interest. Here comes the optimistic role of bioprospecting as a promising tool to isolate novel and interesting molecules and microorganisms from the marine environment as alternatives to the existing resources. Bioprospecting of marine metabolites and microorganisms with high biotechnological potentials has gained wide interest due to the variability and richness of the marine environment. Indeed, the existence of extreme conditions that increases the adaptability of marine organisms, especially planktons, allow the presence of interesting biological species that are able to produce novel compounds with multiple health benefits and high economical value. This review aims to provide a comprehensive overview of marine microbial bioprospecting as a growing field of interest. It emphasizes functional bioprospecting that facilitates the discovery of interesting metabolites. Marine bioprospecting was also discussed from a legal aspect for the first time, focusing on the shortcomings of international law. We also summarized the challenges facing bioprospecting in the marine environment including economic feasibility issues.

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Bacteria From Marine Sponges: A Source of New Drugs

Cited by 65 publications

References 0 publications

Symbiotic Microbes from Marine Invertebrates: Driving a New Era of Natural Product Drug Discovery

Symbiotic Microbes from Marine Invertebrates: Driving a New Era of Natural Product Drug Discovery

Landslide hazard mapping, DNA damage induced by sucrose and the biotechnology potential of sponge-associated bacteria communities

Marine microbial bioprospecting: Exploitation of marine biodiversity towards biotechnological applications—a review

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