Bacteria-mediated tumor immunotherapy via photothermally-programmed PD1 expression

Abstract

The special microenvironment of solid tumor promotes the orientation and colonization of facultative anaerobe. Intratumoral bacterial infection disrupts the local vascular to form thrombosis, resulting in dimmed tumor sites and...

Engineering Microorganisms for Cancer Immunotherapy

“…Engineered microorganisms can be used to deliver immune checkpoint inhibitors (ICIs) directly to the TME, improving the therapeutic efficacy and reducing systemic toxicity. [ 173 ] For example, bacteria engineered to secrete anti‐PD‐1 or anti‐PD‐L1 antibodies have demonstrated the ability to enhance antitumor immunity and inhibit tumor growth in preclinical models. The altered bacteria can accumulate at the tumor locations and produce particular proteins.…”

Polyoxometalate-based nanocomposites for antitumor and antibacterial applications

“…Please do not adjust margins Please do not adjust margins 2.4 Photothermal therapy zPhotothermal therapy (PTT) is an emerging cancer treatment based on the principle of photothermal conversion. [85][86][87] The tissue penetration of near-infrared light is stronger than that of visible and ultraviolet light, and it has less damage to normal tissues. PTT can effectively convert the absorbed near-infrared (NIR) light energy into local hyperthermia, which causes DNA damage, cell membrane destruction and protein denaturation of cancer cells, ultimately leading to cell death.…”