Bacterial adherence and immune response in recurrent urinary tract infection

Suman, Ethel; Bhat, Kamalakshi G.; Bm, Hegde

doi:10.1016/s0020-7292(01)00480-5

Cited by 23 publications

(23 citation statements)

References 14 publications

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“…It may confirm a significant role of this virulence factor among bacterial strains responsible for pyelonephritis. Results of research conducted by Sunman et al (2001) and Raksha et al (2003) also showed hydrophobic nature of the cell surface of E . coli isolated from patients with UTIs.…”

Section: Discussionmentioning

confidence: 79%

Effect of asiatic and ursolic acids on morphology, hydrophobicity, and adhesion of UPECs to uroepithelial cells

2012

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Adhesion of bacteria to epithelial tissue is an essential step in the progression of the urinary tract infections. Reduction of virulence factors responsible for microbial attachment may help to decrease or inhibit colonization of the host organism by pathogens. In the age of increasing bacterial antibiotic resistance, more and more attention is being paid to the use of plants and/or their bioactive components in the prevention and treatment of human infections. Asiatic acid (AA) and ursolic acid (UA), two plant secondary metabolites, were used as potential antibacterial agents. The current study aimed to determine the possible impact of AA and UA on morphology, hydrophobicity, and adhesion of clinical uropathogenic Escherichia coli strains (UPEC) to the uroepithelial cells. Our work describes for the first time the effects exerted by AA and UA on virulence factors of UPECs. The impact of both acids on the cell surface hydrophobicity of the investigated strains was very weak. The results clearly show the influence of AA and UA on the presence of P fimbriae and curli fibers, morphology of the UPECs cells and their adhesion to epithelium; however, some differences between activities of AA and UA were found.

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Section: Discussionmentioning

confidence: 79%

Effect of asiatic and ursolic acids on morphology, hydrophobicity, and adhesion of UPECs to uroepithelial cells

2012

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“…In this study, greater number of the E. coli strains demonstrated hydrophobicity. Previous studies on urinary tract infection cases reported high rate of exhibition of cell surface hydrophobicity by some pathogenic strains of E. coli (Sunman et al, 2001;Raksha et al, 2003). The presence of hydrophobic strains of E. coli in this water sources is an indication that the water could be a potential source of agents of urinary tract infections or gastroenteritis if consumed.…”

Section: Discussionmentioning

confidence: 97%

Virulence factors and antibiotic susceptibility among verotoxic non O157: H7 Escherichia coli isolates obtained from water and wastewater samples in Cape Town, South Africa.

Doughari¹,

Ndakidemi²,

Human³

et al. 2011

Afr. J. Biotechnol.

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Forty eight samples (30 wastewater and 18 river water) were collected between July and November, 2010, from different sources in Cape Town, South Africa in order to characterize verotoxic non O157: H7 Escherichia coli strains. Samples (1 ml) were inoculated into MacConkey broth (MB, 9 ml) and incubated at 37°C for 24 h, after which a loopful of the MB was then spread onto Eosin Methylene Blue (EMB) and further incubated for 24 h at 37°C in order to isolate E. coli. The identification of isolates was done using standard biochemical procedures; and confirmed serologically using E. coli polyvalent antisera (Bioweb, SA). Isolates were also characterized for virulence factors such as verotoxin, haemolysin, gelatinase, extended spectrum beta lactamases (ESBLs), cell surface hydrophobicity and bacterial serum resistance, as well as susceptibility (using disc diffusion method) to stem bark extracts of Curtisia dentata. Results showed the presence of different serotypes of E. coli (69 isolates in all) including 026: H11, 055, O111: NM, O126, O44, O124, O96:H9, O103:H2, O145: NM and O145:H2. Over 60% of the isolates exhibited serum resistance, haemolysin and gelatinase production, 81% exhibited cell surface hydrophobicity and over 52% produced ESBLs. Results also showed that while 60% of the isolates showed various levels of resistance to different antibiotics [ampicillin (10 µg), cefuroxime, cephalexin, ceftazidime and tetracycline (30 µg in each case) (multidrug resistance index (MDRI) values 4.20 to 5.60%)], only 28% were resistant to ethanol stem bark extracts of C. dentata (MIC, 70 to 150 mg/ml). The presence of pathogenic verotoxic antibiotic resistant E. coli in these water sources is a threat to water quality and food security and C. dentata has a potential for sourcing novel antibiotic substances for chemotherapy against these resistant pathogenic strains of E. coli.

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“…This is consistent with the results of previous studies. 6,13 The high hydrophobicity of the bacterial cell surface promotes their adherence to various surfaces like mucosal epithelial cells.…”

Section: Discussionmentioning

confidence: 99%

Virulence factors and drug resistance in <i>Escherichia coli </i>isolated from extraintestinal infections

Sharma¹,

Bhat²,

Shenoy³

2007

Indian J Med Microbiol

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Bacterial adherence and immune response in recurrent urinary tract infection

Abstract: This study showed that increased receptivity of vaginal epithelial cells to pathogens and lower local immunity may play an important role in the pathogenesis of recurrent UTI in females.

Cited by 23 publications

References 14 publications

Effect of asiatic and ursolic acids on morphology, hydrophobicity, and adhesion of UPECs to uroepithelial cells

Effect of asiatic and ursolic acids on morphology, hydrophobicity, and adhesion of UPECs to uroepithelial cells

Virulence factors and antibiotic susceptibility among verotoxic non O157: H7 Escherichia coli isolates obtained from water and wastewater samples in Cape Town, South Africa.

Virulence factors and drug resistance in <i>Escherichia coli </i>isolated from extraintestinal infections

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