Bacterial colonization, enamel defects and dental caries in 4–6‐year‐old mono‐ and dizygotic twins

Ooi, Gregory; Townsend, Grant; Seow, W.K.

doi:10.1111/ipd.12041

Cited by 7 publications

(8 citation statements)

References 32 publications

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“…A study by Gao (1990) from China reported dental caries heritability index of 8.7% in 280 pairs of same-sex twins (186 MZ and 94 DZ). In our study, the ECC heritability estimate was 15%, which is in accordance with some of these reports, indicating a relatively lower genetic influence than the environmental factors (Gao, 1990;Ooi et al, 2014).…”

Section: Figuresupporting

confidence: 93%

Prevalence and Heritability of Early Childhood Caries Among Monozygotic and Dizygotic Twins

et al. 2017

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Deciphering the relative importance of genetic and environmental factors, which play a major role in the prevalence of early childhood caries (ECC), can help clinicians with planning a long-term preventive treatment. The objective of the study was to determine the prevalence and heritability of ECC among monozygotic (MZ) and dizygotic (DZ) twins in Chennai, India, in the year 2013. A cross-sectional study was designed to estimate the prevalence of ECC among twins. Zygosity classification for the survey framework was adapted from a highly accurate parental report questionnaire pertaining to the physical similarity between twins. The associated heritability index was estimated. The Decayed, Missing, Filled Surface (DMFS) Index was used as the diagnostic criterion for dental caries. The prevalence of ECC was estimated at 18.7%. The correlation coefficient between the twin pair showed significant correlation. The heritability index for ECC was estimated at 15% higher prevalence of ECC found among children in the age group 25-36 months. The heritability estimate indicated a relatively low genetic influence for early childhood caries among twins. There was no significant difference detected in the concordance rate for the MZ and DZ twins. Further research could be directed toward the prevalence of ECC among higher age group children to explore the role of genetic and environmental factors.

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Section: Figuresupporting

confidence: 93%

Prevalence and Heritability of Early Childhood Caries Among Monozygotic and Dizygotic Twins

et al. 2017

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“…Several studies have examined the gut microbiota in twins and a few targeted the oral microbiota [17,[41][42][43]. Several of these studies report environmental factors, such as from diet, drugs, and anthropometric measures, to have major impacts on the shaping of the targeted microbial community [44,45], in keeping with our finding that environmental factors were consistently associated with microbiota taxonomy and function.…”

Section: Discussionsupporting

confidence: 74%

Heritability of Oral Microbiota and Immune Responses to Oral Bacteria

et al. 2020

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Maintaining a symbiotic oral microbiota is essential for oral and dental health, and host genetic factors may affect the composition or function of the oral microbiota through a range of possible mechanisms, including immune pathways. The study included 836 Swedish twins divided into separate groups of adolescents (n = 418) and unrelated adults (n = 418). Oral microbiota composition and functions of non-enzymatically lysed oral bacteria samples were evaluated using 16S rRNA gene sequencing and functional bioinformatics tools in the adolescents. Adaptive immune responses were assessed by testing for serum IgG antibodies against a panel of common oral bacteria in adults. In the adolescents, host genetic factors were associated with both the detection and abundance of microbial species, but with considerable variation between species. Host genetic factors were associated with predicted microbiota functions, including several functions related to bacterial sucrose, fructose, and carbohydrate metabolism. In adults, genetic factors were associated with serum antibodies against oral bacteria. In conclusion, host genetic factors affect the composition of the oral microbiota at a species level, and host-governed adaptive immune responses, and also affect the concerted functions of the oral microbiota as a whole. This may help explain why some people are genetically predisposed to the major dental diseases of caries and periodontitis.

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“…Twins research involves comparisons of similarity or discrepancy between monozygotic twins or between monozygotic and dizygotic twins 20 – 22 . According to these comparisons, researchers can estimate the importance of genetic or environmental factors that influence the variation of human physical characteristics 22 – 24 . For example, Townsend et al .…”

Section: Introductionmentioning

confidence: 99%

Research on oral microbiota of monozygotic twins with discordant caries experience - in vitro and in vivo study

Huang

Zeng

et al. 2018

Sci Rep

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Oral microbiome is potentially correlated with many diseases, such as dental caries, periodontitis, oral cancer and some systemic diseases. Twin model, as an effective method for studying human microbiota, is widely used in research of relationship between oral microbiota and dental caries. However, there were few researches focusing on caries discordant twins. In this study, in vitro assays were conducted combined with 16S rRNA sequencing analysis on oral microbiota sampled from twins who presented discordant caries experience and mice model was developed as well. Results showed that oral microbiota from caries-active twin possessed higher metabolic activity and produced more lactic production. 16S rRNA sequencing analysis showed that more than 80% of family taxa could be transferred into gnotobiotic-mice. Key caries-associated genera were significantly different between twins and the same difference in genus level could be found in mice as well (p < 0.05). This study suggested that oral microbiota of twins could be distinguished from each other despite the similarities in genetic make-up, living environment, and lifestyle. The difference in microbiota was applied to develop a mice model which may facilitate the investigation of core microbiota of dental caries.

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Bacterial colonization, enamel defects and dental caries in 4–6‐year‐old mono‐ and dizygotic twins

Cited by 7 publications

References 32 publications

Prevalence and Heritability of Early Childhood Caries Among Monozygotic and Dizygotic Twins

Prevalence and Heritability of Early Childhood Caries Among Monozygotic and Dizygotic Twins

Heritability of Oral Microbiota and Immune Responses to Oral Bacteria

Research on oral microbiota of monozygotic twins with discordant caries experience - in vitro and in vivo study

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