Bacterial extracellular vesicles: Vital contributors to physiology from bacteria to host

Nie, Xinke; Li, Qiqiong; Chen, Xinyang; Onyango, Stanley; Xie, Junhua; Nie, Shaoping

doi:10.1016/j.micres.2024.127733

Microbiological Research

2024

DOI: 10.1016/j.micres.2024.127733

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Bacterial extracellular vesicles: Vital contributors to physiology from bacteria to host

Xinke Nie,

Qiqiong Li,

Xinyang Chen

et al.

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2024

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Cited by 5 publications

References 194 publications

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Potential therapeutic application and mechanism of gut microbiota-derived extracellular vesicles in polycystic ovary syndrome

Yang,

Liu,

Liao

et al. 2024

Biomedicine & Pharmacotherapy

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Potential therapeutic application and mechanism of gut microbiota-derived extracellular vesicles in polycystic ovary syndrome

Yang,

Liu,

Liao

et al. 2024

Biomedicine & Pharmacotherapy

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Impact of probiotics-derived extracellular vesicles on livestock gut barrier function

Zhang,

Song,

Fan

et al. 2024

J Animal Sci Biotechnol

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Probiotic extracellular vesicles (pEVs) are biologically active nanoparticle structures that can regulate the intestinal tract through direct or indirect mechanisms. They enhance the intestinal barrier function in livestock and poultry and help alleviate intestinal diseases. The specific effects of pEVs depend on their internal functional components, including nucleic acids, proteins, lipids, and other substances. This paper presents a narrative review of the impact of pEVs on the intestinal barrier across various segments of the intestinal tract, exploring their mechanisms of action while highlighting the limitations of current research. Investigating the mechanisms through which probiotics operate via pEVs could deepen our understanding and provide a theoretical foundation for their application in livestock production.

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Pathogenic mechanisms and potential applications of extracellular vesicles from periodontal pathogens in periodontitis

Zhang,

Li,

et al. 2024

Front. Immunol.

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Periodontitis is a multifactorial disease characterized by chronic destruction of the periodontal supporting tissues and is closely associated with the dysbiosis of the plaque biofilm. It is the leading cause of tooth loss in adults. Bacterial extracellular vesicles (BEVs) are released from bacteria, which range in size from 20 to 400 nm. These vesicles contain various components derived from their parent bacteria, including nucleic acids, proteins, lipids, and other molecules, which facilitate functions such as molecular transfer, metabolic regulation, bacterial interactions, biofilm formation, and immune modulation. BEVs participated in the pathophysiological process of periodontitis. Recently emerging evidence also showed that the contents of EVs in saliva and gingival crevicular fluid (miRNAs, mRNAs, and proteins) could be used as potential biomarkers for periodontitis. While most current research focuses on human-derived components, much less is known about BEVs. Therefore, this review introduces the formation mechanisms and components of BEVs related to periodontitis. Then, this review summarizes the current information about the mechanism, the diagnostic and theraputic value of periodontal pathogen-derived extracellular vesicles in the development of periodontitis. Furthermore, the future challenges of exploring the role of BEVs in periodontitis are also discussed.

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Bacterial extracellular vesicles: Vital contributors to physiology from bacteria to host

Cited by 5 publications

References 194 publications

Potential therapeutic application and mechanism of gut microbiota-derived extracellular vesicles in polycystic ovary syndrome

Potential therapeutic application and mechanism of gut microbiota-derived extracellular vesicles in polycystic ovary syndrome

Impact of probiotics-derived extracellular vesicles on livestock gut barrier function

Pathogenic mechanisms and potential applications of extracellular vesicles from periodontal pathogens in periodontitis

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