2024
DOI: 10.1042/bst20230229
|View full text |Cite
|
Sign up to set email alerts
|

Bacterial microcompartments as a next-generation metabolic engineering tool: utilizing nature's solution for confining challenging catabolic pathways

Lior Doron,
Cheryl A. Kerfeld

Abstract: Advancements in synthetic biology have facilitated the incorporation of heterologous metabolic pathways into various bacterial chassis, leading to the synthesis of targeted bioproducts. However, total output from heterologous production pathways can suffer from low flux, enzyme promiscuity, formation of toxic intermediates, or intermediate loss to competing reactions, which ultimately hinder their full potential. The self-assembling, easy-to-modify, protein-based bacterial microcompartments (BMCs) offer a soph… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
3
2

Relationship

0
5

Authors

Journals

citations
Cited by 5 publications
(1 citation statement)
references
References 95 publications
0
1
0
Order By: Relevance
“…[33][34][35][36][37][38][39][40][41][42] Notably, BMC shells contribute to metabolic pathway optimization and limit the diffusion of volatile or toxic reaction intermediates. 43 Beyond their function as natural nanoreactors, appealing for synthetic biology, [44][45][46] the extraordinary self-assembly properties of BMC shell components justify a strong interest for varied bio(nano)technological aims. 33,41,42,47,48,[48][49][50][51][52][53][54] The most abundant BMC-shell component is a hexameric assembly known as BMC-H.…”
Section: Introductionmentioning
confidence: 99%
“…[33][34][35][36][37][38][39][40][41][42] Notably, BMC shells contribute to metabolic pathway optimization and limit the diffusion of volatile or toxic reaction intermediates. 43 Beyond their function as natural nanoreactors, appealing for synthetic biology, [44][45][46] the extraordinary self-assembly properties of BMC shell components justify a strong interest for varied bio(nano)technological aims. 33,41,42,47,48,[48][49][50][51][52][53][54] The most abundant BMC-shell component is a hexameric assembly known as BMC-H.…”
Section: Introductionmentioning
confidence: 99%