Bacterial Pharmaceutical Products

Demain, Arnold L.; Lancini, Giancarlo

doi:10.1007/978-3-642-31331-8_28

Cited by 8 publications

(2 citation statements)

References 110 publications

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“…Actinobacteria have been known as a source of antifungal and antibacterial secondary metabolites for many years ( van Wezel and McDowall, 2011 ). The majority of commercialized compounds from Actinobacteria are used for protecting human health ( Demain, 2000 ; Lancini and Demain, 2013 ) but there is growing demand for biological products to help in the control of recalcitrant crop diseases like Fusarium crown rot.…”

Section: Discussionmentioning

confidence: 99%

Developing Actinobacterial Endophytes as Biocontrol Products for Fusarium pseudograminearum in Wheat

O’Sullivan

Roper

Myers

et al. 2021

Front. Bioeng. Biotechnol.

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Crown rot of wheat, caused by Fusarium pseudograminearum, results in millions of dollars of yield losses globally each year. Management strategies to control crown rot are limited and there are concerns about development of fungicide resistance so novel treatment strategies are desirable. A collection of endophytic Actinobacteria was screened for their ability to suppress the growth of F. pseudograminearum and the development of crown rot symptoms in wheat with the aim of identifying candidates that can be developed into biocontrol products. The ability of the Actinobacteria isolates to suppress the growth of three different F. pseudograminearum strains in vitro was assessed using agar-plate competition assays. Soil-free seedling assays were used to screen for suppression of development of early disease symptoms in the susceptible wheat (Triticum aestivum) cv. Tamaroi. Four of the isolates were tested in a glasshouse pot experiment to assess their ability to decrease disease symptoms and prevent yield losses in wheat cv. Tamaroi grown to maturity in an unsterilized soil. The screening of 53 isolates identified two Streptomyces isolates, MH71 and MH243, with very strong antifungal activity against F. pseudograminearum strains in agar-plate competition and seedling assays. In the glasshouse pot trial, plants treated with seed coatings of either MH71 or MH243 had > 24% lower disease severity than control plants infected with F. pseudograminearum. These two cultures show potential for development as biocontrol products because they are easy to culture, grow on relatively inexpensive media, produce highly durable spores and can be delivered to plants as a seed coat.

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Section: Discussionmentioning

confidence: 99%

Developing Actinobacterial Endophytes as Biocontrol Products for Fusarium pseudograminearum in Wheat

O’Sullivan

Roper

Myers

et al. 2021

Front. Bioeng. Biotechnol.

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“…Pharmaceutical agents of bacterial origin include antibiotics, immunomodulators, nematicides, antitumor agents, coccidiostatic agents, enzyme inhibitors, and insecticides. Interestingly, Escherichia coli is used as a host in molecular biology for synthesis of recombinant proteins [76]. Selman Abraham Waksman, the father of antibiotics, discovered actinomycin; this effort was followed by the discovery of streptomycin in 1944 [77].…”

Section: The Pharmacological Activities Of Bacterial-derived Secondar...mentioning

confidence: 99%

Secondary Metabolites: The Natural Remedies

Mikail¹,

Mamman²,

Umar³

et al. 2022

Secondary Metabolites - Trends and Reviews

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The chapter discusses the meaning and origin of some important classes of secondary metabolites such as alkaloids, terpenoids, tannins, flavonoids, saponins, glycosides, and phenolic compounds, etc., produced by some bacteria, fungi, or plants. Very important drugs that are used clinically are derived from these secondary metabolites. Several reports obtained in scientific journals and books written by different scientists working or who have worked in the fields of natural products medicine were reviewed. These different classes of secondary metabolites have shown activity against varied diseases, and compounds that are of novel structure and activity have been isolated and characterized from them. The chapter highlights the economic impacts of these chemical compounds including their role in improving human and animal health and well-being by serving as sources of some antibiotics, anticancer, anti-inflammatory, antifertility, antidiabetics, analgesics, growth promoters, etc. Secondary metabolites are also used to enhance agricultural productivity, they find uses as pesticides, insecticides, and preservatives. Some folkloric uses of secondary metabolites chemical compounds based on reliable sources of information and genuine scientific investigations are highlighted.

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Microbes in Pharmaceutical Industry

Kapoor

Sharma

et al. 2020

Microbial Diversity, Interventions and Scope

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Bacterial Pharmaceutical Products

Cited by 8 publications

References 110 publications

Developing Actinobacterial Endophytes as Biocontrol Products for Fusarium pseudograminearum in Wheat

Developing Actinobacterial Endophytes as Biocontrol Products for Fusarium pseudograminearum in Wheat

Secondary Metabolites: The Natural Remedies

Microbes in Pharmaceutical Industry

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