Bacterial Resistance to Antimicrobial Agents

Varela, Manuel F.; Stephen, Jerusha; Lekshmi, Manjusha; Ojha, Manisha; Wenzel, Nicholas; Sanford, Leslie M.; Hernández, Arelys Falcón; Parvathi, Ammini; Kumar, Sanath

doi:10.3390/antibiotics10050593

Cited by 153 publications

(118 citation statements)

References 187 publications

(234 reference statements)

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“…In fact, they are not effective against third-generation cephalosporins, such as cefotaxime, ceftazidime, and ceftriaxone, and fourth-generation cephalosporins, such as cefepime. Based upon different single amino acid substitutions, currently 140 TEM type enzymes have been described [ 7 , 8 , 9 ].…”

Section: A Global Overview Of Genes Encoding β-Lactamasesmentioning

confidence: 99%

“…Clavulanic acid inhibits these enzymes, and these organisms are susceptible to cephamycins (cefoxitin) and carbapenems (imipenem). They are the predominant ESBL type in Europe and the United States and are found worldwide [ 7 , 8 , 9 ].…”

Section: A Global Overview Of Genes Encoding β-Lactamasesmentioning

confidence: 99%

“…They are the predominant ESBL type in South America. CTX- M-14, CTX-M-3, and CTX-M-2 are the most common enzymes [ 7 , 8 , 9 ]. The CTX-M family became predominant over TEM and SHV during the first decade of the 21st century [ 10 ].…”

Section: A Global Overview Of Genes Encoding β-Lactamasesmentioning

confidence: 99%

“…Carbapenems can usually be used to treat infections due to AmpC-producing bacteria, but carbapenem resistance has been reported in some organisms, since mutations can reduce influx (outer membrane porin loss) or enhance efflux (efflux pump activation). These enzymes present a very great geographic distribution and, therefore, accurate detection and characterization are important not only for epidemiological control, but also for clinical, laboratory, and infection points of view [ 7 , 8 , 9 ].…”

Section: A Global Overview Of Genes Encoding β-Lactamasesmentioning

confidence: 99%

“…OXA-51, OXA-23, and OXA-58 are more prevalent in Acinetobacter spp., due to genetic circulation and horizontal gene exchange mechanisms observed in P. aeruginosa. OXA-17 confers greater resistance to cefotaxime and cefepime [ 7 , 8 , 9 ].…”

Section: A Global Overview Of Genes Encoding β-Lactamasesmentioning

confidence: 99%

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Old and New Beta-Lactamase Inhibitors: Molecular Structure, Mechanism of Action, and Clinical Use

et al. 2021

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The β-lactams have a central place in the antibacterial armamentarium, but the increasing resistance to these drugs, especially among Gram-negative bacteria, is becoming one of the major threats to public health worldwide. Treatment options are limited, and only a small number of novel antibiotics are in development. However, one of the responses to this threat is the combination of β-lactam antibiotics with β-lactamase inhibitors, which are successfully used in the clinic for overcoming resistance by inhibiting β-lactamases. The existing inhibitors inactivate most of class A and C serine β-lactamases, but several of class D and B (metallo-β-lactamase) are resistant. The present review provides the status and knowledge concerning current β-lactamase inhibitors and an update on research efforts to identify and develop new and more efficient β-lactamase inhibitors.

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Section: A Global Overview Of Genes Encoding β-Lactamasesmentioning

confidence: 99%

Section: A Global Overview Of Genes Encoding β-Lactamasesmentioning

confidence: 99%

Section: A Global Overview Of Genes Encoding β-Lactamasesmentioning

confidence: 99%

Section: A Global Overview Of Genes Encoding β-Lactamasesmentioning

confidence: 99%

Section: A Global Overview Of Genes Encoding β-Lactamasesmentioning

confidence: 99%

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Old and New Beta-Lactamase Inhibitors: Molecular Structure, Mechanism of Action, and Clinical Use

et al. 2021

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Nanotechnology for Targeted Detection and Removal of Bacteria: Opportunities and Challenges

et al. 2021

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The emergence of nanotechnology has created unprecedented hopes for addressing several unmet industrial and clinical issues, including the growing threat so-termed "antibiotic resistance" in medicine. Over the last decade, nanotechnologies have demonstrated promising applications in the identification, discrimination, and removal of a wide range of pathogens. Here, recent insights into the field of bacterial nanotechnology are examined that can substantially improve the fundamental understanding of nanoparticle and bacteria interactions. A wide range of developed nanotechnology-based approaches for bacterial detection and removal together with biofilm eradication are summarized. The challenging effects of nanotechnologies on beneficial bacteria in the human body and environment and the mechanisms of bacterial resistance to nanotherapeutics are also reviewed.

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Antibacterial and Toxic Activity of Geopropolis Extracts from Melipona subnitida (Ducke, 1910) (Hymenoptera: Apidae) and Scaptotrigona depilis (Moure, 1942) (Hymenoptera: Apidae)

Costa dos Santos,

Silva Macêdo,

de Sousa Silveira

et al. 2023

Chemistry & Biodiversity

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Bacteria are associated with many infections that affect humans and present antibiotic resistance mechanisms, causing problems in health organisations and increased mortality rates. Therefore, it is necessary to find new antibacterial agents that can act in the treatment of these microorganisms. Geopropolis is a natural product made by stingless bees, formed by a mixture of plant resins, salivary secretions, wax and soil particles, presenting a diverse chemical composition. Thus, this study aimed to evaluate antibacterial activity, antibiotic modulation and the toxicity of geopropolis extract from the stingless bees, Melipona subnitida (Ducke, 1910) and Scaptotrigona depilis (Moure, 1942) against standard and multi‐resistant Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa bacteria. Geopropolis samples were collected in a meliponary located in Camaragibe, Pernambuco, Brazil. To determine the Minimum Inhibitory Concentration (MIC) and antibiotic modulation we performed broth microdilution tests. Mortality tests were used to verify extract toxicity in the model Drosophila melanogaster. The microbiological tests showed that the M. subnitida extracts had better inhibitory effects compared to S. depilis, presenting direct antibacterial activity against standard and multi‐resistant strains. The extracts potentialized antibiotic effects, suggesting possible synergy and did not present toxicity in the model used.

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Bacterial Resistance to Antimicrobial Agents

Cited by 153 publications

References 187 publications

Old and New Beta-Lactamase Inhibitors: Molecular Structure, Mechanism of Action, and Clinical Use

Old and New Beta-Lactamase Inhibitors: Molecular Structure, Mechanism of Action, and Clinical Use

Nanotechnology for Targeted Detection and Removal of Bacteria: Opportunities and Challenges

Antibacterial and Toxic Activity of Geopropolis Extracts from Melipona subnitida (Ducke, 1910) (Hymenoptera: Apidae) and Scaptotrigona depilis (Moure, 1942) (Hymenoptera: Apidae)

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