Bacterial rRNA A-site recognition by DAPI: Signatures of intercalative binding

Parameswaran, Preethi; Arora, Yashaswina; Patidar, Rajesh Kumar; Ranjan, Nihar

doi:10.1016/j.bpc.2021.106589

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Fluorescent Studies With Dapi and Acridine Orange Probes: In...1

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2024

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“…DAPI has high affinity and specificity for the minor groove of DNA, which is a region rich in AT (adenine-thymine) sequences. One of the most striking features of this binding is the increased fluorescence intensity of the DNA-DAPI complex (Parameswaran et al 2021).…”

Section: Fluorescent Studies With Dapi and Acridine Orange Probes: In...mentioning

confidence: 99%

Preliminary evaluation of the interaction with Albumin/DNA and in vitro evaluation of the antioxidant properties promoted by thiosemicarbazones and thiazole compounds

Nascimento,

Santos,

Pereira

et al. 2024

Sci. Electronic Arch

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Thiosemicarbazones and thiazoles are known for their diverse biological activities. This study introduced two series of molecules, 4-(3-(4-nitrophenyl)-4-phenylthiazol-2(3H)-ylidene)-hydrazine)-methyl)-phenol and 4-(3-(4-chlorophenyl)-4-phenylthiazol-2(3H)-ylidene)-hydrazine)-methyl)-phenol, which exhibit biological potential as antioxidant agents. The study also assessed the interaction of these compounds with various HSA/DNA macromolecules. The results of the antioxidant activity showed that thiazoles in the DPPH assay exhibited IC50 values ranging from 439.4 to 691.67 µM. In the ABTS assay, thiosemicarbazones exhibited significant activity, ranging from 39.19 to 50.03 µM. Interaction assays were carried out with human serum albumin (HSA) and DNA. All compounds were able to interact with both DNA (low to moderate interaction) and HSA (moderate to high interaction).

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Section: Fluorescent Studies With Dapi and Acridine Orange Probes: In...mentioning

confidence: 99%