Bacterial vaginosis and cervical intraepithelial neoplasia

Platz-Christensen, Jens-Jörgen; Sundström, Ewa; Larsson, Per‐Göran

doi:10.3109/00016349409006278

Cited by 91 publications

(58 citation statements)

References 19 publications

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“…17 These opportunistic agents would be favored by imbalances in the vaginal flora. 18 According to Edwards, 1 Escherichia coli was the species most associated with bacterial vaginitis, although in the present series, it was found that Staphylococcus aureus was the agent most frequently causing it. Vaginal infections due to Bacteroides sp., Peptostreptococcus sp., Prevotella sp.…”

Section: Discussionmentioning

confidence: 55%

Prevalence of vulvovaginitis and bacterial vaginosis in patients with koilocytosis

et al. 2008

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CONTEXT AND OBJECTIVE: Empirical discussion regarding an association between koilocytosis and vulvovaginitis often occurs. Thus, the objective of this study was to assess the prevalence of microorganisms associated with bacterial vaginosis and vulvovaginitis in women with and without koilocytosis. DESIGN AND SETTING:Analytical cross-sectional study including two cohorts of women (with and without koilocytosis) who attended a cancer hospital in the city of Goiânia, state of Goiás. METHODS:A total of 102 patients entered the study. The whiff test, Gram and Papanicolaou staining and bacterial and fungal culturing were performed. The results were observed using univariate analysis. The odds ratio and confi dence interval (CI) of the variables were calculated; P-values < 0.05 were considered signifi cant. RESULTS:The prevalence of bacterial colonization was similar in patients with and without koilocytosis. The odds ratio for candidiasis was 1.43 (CI 1.05-1.95) and the odds ratio for trichomoniasis was 1.78 (CI 1.49-2.12), in patients with koilocytosis.

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Section: Discussionmentioning

confidence: 55%

Prevalence of vulvovaginitis and bacterial vaginosis in patients with koilocytosis

et al. 2008

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“…Previous studies which have examined the relationship between BV and cervical intraepithelial neoplasia (CIN) gave conflicting conclusions with different results which ranged from a strong association [1] to no association at all [2]. In the earlier eighties Pavić [3], discussing possible analogies between gastric and cervical cancer, concluded that in both, an elevation of pH could encourage proliferation of bacteria, and those situation could be preceded by epithelial metaplasia and dysplasia.…”

mentioning

confidence: 99%

Relationship among bacterial vaginosis, local inflammatory response and presence of cervical intraepithelial neoplasia in women with and without human papilloma virus infection

Vesna

Basheska

Zlatka

et al. 2012

Korean J Obstet Gynecol

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“…Because of the improper use of OTC antifungal medications, the vaginal microflora may be altered 26 and opportunistic infections such as BV may go unchecked and untreated. Vaginitis, in particular BV, has been associated with increased risk of serious obstetric and gynecologic complications and disorders [27][28][29][30][31] . Since the patient is advised to see her doctor/ healthcare provider when the test is positive (pH > 4.5), a false-positive test would only cause the symptomatic patient to visit her healthcare provider for proper diagnosis of an abnormal condition.…”

Section: Discussionmentioning

confidence: 99%

Improving Appropriate Use of Antifungal Medications: The Roleof an Over‐the‐Counter Vaginal pH Self‐Test Device

Roy¹,

Caillouette²,

Faden³

et al. 2003

Infectious Diseases in Obstetrics and Gynecology

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Objectives:To determine whether patients can understand and use the vaginal pH device in the diagnosis of vaginitis. To compare whether vaginal pH readings determined by patients and healthcare providers are similar. To determine whether vaginal pH can reduce inappropriate over-the-counter (OTC) antifungal medication use and improve the correct diagnosis of vaginitis. Methods: One hundred and fifty-one women indicated their belief about the cause of their vaginal infection, read the instructions of the vaginal pH device package insert, used the device and interpreted the findings. The patient interpretations were compared with results obtained by healthcare providers, blinded to patient findings. Results: Over 96% of patients stated that they could easily read the instructions, use the vaginal pH device and interpret the readings. They obtained the same readings as healthcare professionals (Kappa = 0.9). Restricting the use of OTC antifungal medications to those individuals with vaginitis symptoms and vaginal pH ≤ 4.5 significantly reduced inappropriate use by approximately 50%, Fisher's exact test, p-value = 0.018. Conversely, seeking healthcare provider assessment with vaginal pH > 4.5, leads to correct diagnosis of vaginitis. Conclusions: The vaginal pH device can be used as an OTC diagnostic tool by consumers when a vaginal infection is suspected. Vaginal pH readings would direct patients whether to purchase an antifungal medication or seek professional diagnosis from a healthcare provider. Understanding and use of this vaginal pH device could reduce inappropriate use of OTC antifungal medications by approximately 50% and improve the correct diagnosis of vaginitis.

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Bacterial vaginosis and cervical intraepithelial neoplasia

Abstract: The possibility exists that bacterial vaginosis is in some way associated with the development of cervical intraepithelial neoplasia, i.e. as a cofactor to human papilloma virus. Therefore, bacterial vaginosis must be taken in consideration in future studies on CIN.

Cited by 91 publications

References 19 publications

Prevalence of vulvovaginitis and bacterial vaginosis in patients with koilocytosis

Prevalence of vulvovaginitis and bacterial vaginosis in patients with koilocytosis

Relationship among bacterial vaginosis, local inflammatory response and presence of cervical intraepithelial neoplasia in women with and without human papilloma virus infection

Improving Appropriate Use of Antifungal Medications: The Roleof an Over‐the‐Counter Vaginal pH Self‐Test Device

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