Bactericidal Action of Binary and Ternary Mixtures of Carvacrol, Thymol, and Eugenol against <i>Listeria innocua</i>

García‐García, Rebeca; López‐Malo, Aurelio; Palou, Enrique

doi:10.1111/j.1750-3841.2010.02005.x

Cited by 128 publications

(75 citation statements)

References 31 publications

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“…Numerous studies have demonstrated the bactericidal [30], fungicidal [31] and insecticidal [32] activity of CAR. CAR has shown anti-tumorigenic activity in hepatocellular carcinoma, both in vitro and in vi o [33,34].…”

Section: Discussionmentioning

confidence: 99%

Carvacrol prevents methotrexate-induced renal oxidative injury and renal damage in rats

Bozkurt¹,

Em²,

Oktayoğlu³

et al. 2014

CIM

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TurkeyCarvacrol prevents methotrexateinduced renal oxidative injury and renal damage in rats AbstractPurpose: e purpose of this study was to investigate the e ect of carvacrol (CAR) on methotrexate (MTX)-induced renal damage in rats.Methods: Twenty-four male rats were equally divided into three groups: group I, control treatment; group II, MTX-treated; and group III, MTX+CAR-treated. A single dose of CAR (73 mg/kg) was administered intraperitoneally to group III on the rst day of the experiment and a single dose of MTX (20 mg/kg) was administered intraperitoneally to groups II and III on the second day of the experiment. Blood samples and kidney tissue were obtained from each animal on day 8 for the measurement of malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI). Light microscopy was used for histopathological examination of kidney specimens.Results: MDA, TOS and OSI levels were signi cantly greater in the group receiving MTX alone relative to the control animals, while the TAS level was signi cantly reduced in the MTX group compared with the control group. e administration of CAR was associated with signi cantly decreased MDA, TOS, and OSI levels and increased TAS levels relative to the rats treated with MTX alone. Animals treated with CAR exhibited decreased tubular degeneration and architectural impairment relative to animals treated with MTX alone; however, the di erence in histological scores did not meet the threshold of statistical signi cance. e folic acid antagonist methotrexate (MTX) is used clinically to inhibit the synthesis of purines and pyrimidines [1]. MTX is commonly used at high doses to limit the growth of malignancies, but may also be used at low doses in in ammatory diseases, including psoriasis and rheumatoid arthritis, to inhibit the proliferation of in ammatory leukocytes [2][3][4]. MTX remains an essential component of modern clinical therapy for acute lymphoblastic leukemia and is the primary treatment for malignant gestational trophoblastic disease [5]. In addition to anti-proliferative activity, MTX has antiin ammatory and immunomodulatory properties; however, cytotoxic e ects and other side e ects limit the e cacy of MTX as an anti-in ammatory. Signi cant side e ects of MTX have been described in several organ systems. In particular, MTX has a detrimental e ect on kidney function [6]; however, the mechanism of MTX-induced toxicity remains unclear. More than 90% of MTX is ltered by the kidneys [7] and MTX treatment is known to cause renal failure at high doses [8]. Renal impairment can result in altered metabolism of MTX, delayed drug excretion and, subsequently, systemic toxicity. e toxic e ects of MTX are typically treated through hydration and alkalinization of the patient; however, these methods are insu cient to prevent all instances of MTX toxicity. Reactive oxygen species (ROS) have been implicated in the pathogenesis of MTX-induced renal damage [9,10]. MTX produces free oxygen radicals, resulting in enhanced li...

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Section: Discussionmentioning

confidence: 99%

Carvacrol prevents methotrexate-induced renal oxidative injury and renal damage in rats

Bozkurt¹,

Em²,

Oktayoğlu³

et al. 2014

CIM

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“…It was suggested that p-cymene induces swelling of bacterial cell membranes that enable easier entry of carvacrol into the cell membrane [49]. García-García et al [50] found the most Allium sativum (Garlic) belongs to family Liliaceae is a perennial bulb-forming plant. Garlic has been used for dietary and therapeutic purposes [51].…”

Section: Synergy Among Herbal Antimicrobialsmentioning

confidence: 99%

Potential of Herbal Drug and Antibiotic Combination Therapy: A New Approach to Treat Multidrug Resistant Bacteria

Bhardwaj¹,

BR²,

DK³

2016

Pharm Anal Acta

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“…They can be sourced from over 1,300 plants such as thyme (thymol), oregano (carvacrol), clove (eugenol), orange (limonene), and cinnamon (cinnamaldehyde) (Chao et al 2000;Velluti et al 2003;Holley and Patel 2005). Phenolic compounds such as thymol, carvacrol and eugenol are known as EOs possessing the most potent antibacterial properties (García-García et al 2011). Recent demonstration states that, the inhibition of a wide range of bacterial species, including, E. coli O157:H7, Listeria monocytogenes, Staphylococcus aureus, Salmonella typhymurium (Oussalah et al 2007) and several other fungi by essential oil treatment (De Martino et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Nanoemulsion of orange oil with non ionic surfactant produced emulsion using ultrasonication technique: evaluating against food spoilage yeast

et al. 2015

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In recent years, food industries have shown great interest in developing nanoemulsion (NE) using essential oils (EOs) to prevent food spoilage caused by microorganisms. The hydrophobic properties of EOs have lead to reduced solubilization effect of food, which in turn, created a negative impact on the quality of food and its antimicrobial efficacy. Focusing this issue, we attempted a unique NE preparation using orange oil, Tween 80 (organic phase) and water (aqueous phase) by sonication technique. Based on thermodynamic stability studies, the effective diameter was reported to be in the size range from 20 to 30 nm. Saccharomyces cerevisiae was used in testing the anti-yeast effect. Their activity was studied in both growth medium and apple juice. The minimum inhibitory concentration of this NE was determined using broth dilution method. At 2 ll/ml, orange oil NE demonstrated inhibition of tested microorganisms. The kinetics of killing curve, have shown that the NE treated cells had lost its viability within 30 min of interaction. Also, SEM image revealed that the treated cells became distorted in comparison to their control cells. NE treated apple juice showed complete loss of viability even on dilution as compared to their controls.

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Bactericidal Action of Binary and Ternary Mixtures of Carvacrol, Thymol, and Eugenol against Listeria innocua

Cited by 128 publications

References 31 publications

Carvacrol prevents methotrexate-induced renal oxidative injury and renal damage in rats

Carvacrol prevents methotrexate-induced renal oxidative injury and renal damage in rats

Potential of Herbal Drug and Antibiotic Combination Therapy: A New Approach to Treat Multidrug Resistant Bacteria

Nanoemulsion of orange oil with non ionic surfactant produced emulsion using ultrasonication technique: evaluating against food spoilage yeast

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