Bactericidal activity of three different antiseptic ophthalmic preparations as surgical prophylaxis

Tognetto, Daniele; Pastore, Marco R; Guerin, Gian Marco; Decorti, Giuliana; Franzin, Martina; Lagatolla, Cristina; Cirigliano, Gabriella

doi:10.1007/s00417-021-05361-3

Cited by 15 publications

(9 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…According to the results, each formulation prevents bacterial growth once challenged, with the exception of Dropsept, which was not able to limit P. aeruginosa. Our data are not in line with Tognetto et al (2022), who published a microbicidal effect only for Iodim [40].…”

Section: Discussioncontrasting

confidence: 99%

Comparative Evaluation of Antimicrobial, Antiamoebic, and Antiviral Efficacy of Ophthalmic Formulations

et al. 2022

View full text Add to dashboard Cite

The extensive use of ophthalmic antibiotics is contributing to the appearance of resistant bacterial strains, which require prolonged and massive treatments with consequent detrimental outcomes and adverse effects. In addition to these issues, antibiotics are not effective against parasites and viruses. In this context, antiseptics could be valuable alternatives. They have nonselective mechanisms of action preventing bacterial resistance and a broad spectrum of action and are also effective against parasites and viruses. Here, we compare the in vitro antibacterial, antiameobic, and antiviral activities of six ophthalmic formulations containing antiseptics such as povidone-iodine, chlorhexidine, and thymol against Gram-positive and Gram-negative bacteria, the amoeba Acanthamoeba castellanii, and two respiratory viruses, HAdV-2 and HCoV-OC43. The results suggest that, among all the tested formulations, Dropsept, consisting of Vitamin E TPGS-based (tocopheryl polyethylene glycol succinate) in combination with the antiseptic chlorhexidine, is the one with the highest range of activities, as it works efficiently against bacteria, amoeba, and viruses. On the other hand, the solution containing PVA (polyvinyl alcohol) and thymol showed a promising inhibitory effect on Pseudomonas aeruginosa, which causes severe keratitis. Given its high efficiency, Dropsept might represent a valuable alternative to the widely used antibiotics for the treatment of ocular infections. In addition to this commercial eye drop solution, thymol-based solutions might be enrolled for their natural antimicrobial and antiamoebic effect.

show abstract

Section: Discussioncontrasting

confidence: 99%

Comparative Evaluation of Antimicrobial, Antiamoebic, and Antiviral Efficacy of Ophthalmic Formulations

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Dropsept (Iromed Group s.r.l, Rome, Italy), a new preparation based on CHX 0.02%, Vitamin E and D-a-Tocopherol polyethylene glycol 1000 succinate, was recently introduced. An in vitro study by Tognetto et al showed a good antiseptic activity against E. coli, a weaker activity against the staphylococci strains and P. aeruginosa, while Candida albicans was not affected [49]. Similar in vitro results were shown by Caruso et al, with effective bactericidal activity on S. aureus, S. epidermidis, and Escherichia coli, but with no inhibitory effect on the growth of P. aeruginosa.…”

Section: Chlorhexidine (Chx)mentioning

confidence: 56%

“…Again in vitro, Tognetto et al showed antimicrobial efficacy of Ozodrop against S. epidermidis, E. coli, and P. aeruginosa. Moreover, no activity was detected against S. aureus strains and C. albicans [49]. Focusing on the anti-Candida effect, Celenza et al showed an antifungal effect on several Candida species [65].…”

Section: Ozonementioning

confidence: 99%

“…This study showed a reduction of [ 90% in microbial load in [ 90% of the samples presented in the group treated with Ozodrop, with optimal ocular tolerability. Liposomal ozonated oil has shown similar effects to other traditional antiseptics, with a wide antimicrobial power and a low rate of adverse events [49,50]. Therefore, it may be an interesting option before ophthalmic surgery as an alternative to traditional compounds.…”

Section: Ozonementioning

confidence: 99%

See 1 more Smart Citation

Prophylaxis of Ocular Infection in the Setting of Intraocular Surgery: Implications for Clinical Practice and Risk Management

et al. 2023

View full text Add to dashboard Cite

In this review we discuss the role of intraocular surgery preoperative prophylaxis. The correct choice of antimicrobial drug is variable in each surgical setting, according to the available strengths of evidence, the anatomical district involved, and the type of procedure. In the ophthalmic surgical field, there has been a progressive shift from antibiotic formulations, which are known to cause antibiotic resistance, to a new class of antiseptic compounds, which proved to be effective not only against bacteria, but also against fungi, protozoa, and viruses. Among these, povidone-iodine (PVI) is a watersoluble polymer that can form a complex with iodine, and the perioperative application of PVI 5-10% eye drop for 3 min is the gold standard for infection prophylaxis. A new formulation of 0.6% PVI eye drop is a new option for infection prophylaxis in the days before surgery. Chlorhexidine is a biguanide compound, which is a valid alternative with a good safety and efficacy profile and is the antiseptic of choice in patients with iodine allergy. New compounds that are currently being studied include polyhexamethylene biguanide (PHMB), picloxydine, ozone, hypochlorous acid (HOCl), and Biosecur. PHMB is a biguanide polymer that was found to be more effective than PVI in in vitro studies for reducing microorganisms and extending the duration of antisepsis, but to date, there are no formulations available on the market for preoperative ocular surgery in which it is present as main ingredient. Ozone is a molecule with oxidizing effect, which showed interesting preliminary results but is not effective against virus, Staphylococcus aureus and Candida albicans. HOCl has a natural bactericidal propriety but its applicability to prophylaxis of ocular infection in the setting of ocular surgery is not established. Biosecur is a non-toxic organic alcohol-free compound that exhibited

show abstract

“…Furthermore, it promotes the release of growth factors promoting wound healing, such as PDGF and TGF-β, and collagen synthesis. However, ozone alone cannot be used in otological preparations, as it would cause irritation of the mucous membranes of the ear [34]. On the contrary, the combination with liposomes, which are spherical vesicular structures in aqueous suspension made up of phospholipids organized in a bilayer, stabilizes ozone and makes it tolerated by the ear surface.…”

Section: Discussionmentioning

confidence: 99%

Perspectives of Italian Physicians and Patients in the Treatment of Otitis Externa: A Real-Life Study

Gelardi

Giancaspro

Landi³

et al. 2023

JPM

View full text Add to dashboard Cite

(1) Background: Otitis externa (OE) is a common inflammatory disease of the external ear canal. Given the numerous manifestations of OE, the high rate of recurrence of the disease, as well as the emergence of resistance to antibiotics, therapeutic strategies are numerous and still not well standardized. The aim of this study was to investigate the patient journey of Italian patients suffering from OE, paying greater attention to new therapeutic options. (2) Methods: We conducted a national survey to evaluate the characteristics of patients affected by OE and to analyze the most-prescribed treatments. (3) Results: OE is a common, often relapsing disease that has several clinical manifestations. Prior to observation, the combination of corticosteroids and topical antibiotics was the most common therapeutic strategy. At the time of observation, new liposomal ozone-based preparations were the most-prescribed treatment. (4) Conclusions: This multi-center study investigated key aspects of the OE patient journey, highlighting the growing problem of antibiotic resistance. Restoring a correct ear microbiome is the therapeutic goal. In this context, new liposomal ozone-based drugs represent a promising therapeutic strategy.

show abstract

Bactericidal activity of three different antiseptic ophthalmic preparations as surgical prophylaxis

Cited by 15 publications

References 30 publications

Comparative Evaluation of Antimicrobial, Antiamoebic, and Antiviral Efficacy of Ophthalmic Formulations

Comparative Evaluation of Antimicrobial, Antiamoebic, and Antiviral Efficacy of Ophthalmic Formulations

Prophylaxis of Ocular Infection in the Setting of Intraocular Surgery: Implications for Clinical Practice and Risk Management

Perspectives of Italian Physicians and Patients in the Treatment of Otitis Externa: A Real-Life Study

Contact Info

Product

Resources

About