Bactericidal Effects of Aspergillus clavatus

Wiesner, B

doi:10.1038/149356b0

Cited by 33 publications

(8 citation statements)

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“…In preparing enzyme concentrates from certain moulds, antibacterial activity was noted in extract from a number of species characterized by high proteolytic capacity. Thus, two strains of A. clavatus were able to synthesise and release bactericidal products, into the liquid media, which possessed antibacterial activities against S. aureus and other bacteria (Wiesner 1942). In a study conducted by Foster and Karow (1945), antibacterial substances present in culture filtrates of A. niger (YWA), A. nidulans, A. oryzae (TP), and A. flavipes are either identical with, or closely related to, authentic penicillin produced by Penicillium notatum.…”

Section: Antibacterial Properties Of Crude Extractsmentioning

confidence: 99%

Overview on antibacterial metabolites from terrestrialAspergillusspp

Al-Fakih

Almaqtri

2019

Mycology

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Medicines developed from natural sources are a frequent target for the research and discovery of antimicrobial compounds. Discovering of penicillin in 1928 was a motive to explore of nature as a source of new antimicrobial agents. Fungi produce a diverse range of bioactive metabolites, making them rich source of different types of medicines. The purpose of this paper was to review studies on antibacterials from terrestrial Aspergillus published exclusively during 1942-2018, with emphasis on their antibacterial activities, structures, and mechanisms of action if present. According to the results from different studies in the world, large number of compounds and extracts showed different activities against different bacterial species, including Gram-positive and Gram-negative bacteria. The most prominent result was that of the compound CJ-17,665, isolated from A. ochraceus, showing good activity against multi-drug resistant Staphylococcus aureus, which is well-recognised to be one of the most important current public health problem. These findings may motivate scientists to undertake a project that may result in the development of novel antibacterial drugs from terrestrial-derived Aspergillus spp., although further toxicity assays (in vivo) must be performed before their application.

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Section: Antibacterial Properties Of Crude Extractsmentioning

confidence: 99%

Overview on antibacterial metabolites from terrestrialAspergillusspp

Al-Fakih

Almaqtri

2019

Mycology

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“…Penicillium expansum is the most common fungus that causes blue mold and patulin contamination in stored apples [5]. Patulin was first isolated from Aspergillus clavatus and studied in the early 1940s [6,7]. Patulin contamination is a world-wide problem including, Portugal [8,9], Belgium [10], India [11], Northeast China [12].…”

Section: Introductionmentioning

confidence: 99%

The Possible Mechanisms Involved in Degradation of Patulin by Pichia caribbica

Zheng¹,

Yang²,

Zhang³

et al. 2016

Toxins

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In this work, we examined the mechanisms involved in the degradation of patulin by Pichia caribbica. Our results indicate that cell-free filtrate of P. caribbica reduced patutlin content. The heat-killed cells could not degrade patulin. However, the live cells significantly reduced the concentration of the patulin. In furtherance to this, it was observed that patulin was not detected in the broken yeast cells and cell wall. The addition of cycloheximide to the P. caribbica cells decreased the capacity of degradation of patulin. Proteomics analyses revealed that patulin treatment resulted in an upregulated protein which was involved in metabolism and stress response processes. Our results suggested that the mechanism of degradation of patulin by P. caribbica was not absorption; the presence of patulin can induce P. caribbica to produce associated intracellular and extracellular enzymes, both of which have the ability to degrade patulin. The result provides a new possible method that used the enzymes produced by yeast to detoxify patulin in food and feed.

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“…These metabolites are harmful to humans and include compounds like aflatoxins, trichothecenes, and other mycotoxins that represent a serious health hazard. Patulin (4-hydroxy-4H-furo [3,2c]pyran-2[6H]-one) is a mycotoxin that was first isolated from Aspergillus clavatus and studied in the early 1940s (1,2). Initial interest in this molecule was due to its antibacterial activity, and its investigation featured such pioneers in the development of antimicrobial agents as the Nobel laureates Selman Waksman, Howard Florey, and Ernest Chain (see early discoveries in references 3 and 4).…”

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confidence: 99%

Searching for Genes Responsible for Patulin Degradation in a Biocontrol Yeast Provides Insight into the Basis for Resistance to This Mycotoxin

Ianiri

Idnurm

Wright

et al. 2013

Appl Environ Microbiol

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f Patulin is a mycotoxin that contaminates pome fruits and derived products worldwide. Basidiomycete yeasts belonging to the subphylum Pucciniomycotina have been identified to have the ability to degrade this molecule efficiently and have been explored through different approaches to understand this degradation process. In this study, Sporobolomyces sp. strain IAM 13481 was found to be able to degrade patulin to form two different breakdown products, desoxypatulinic acid and (Z)-ascladiol. To gain insight into the genetic basis of tolerance and degradation of patulin, more than 3,000 transfer DNA (T-DNA) insertional mutants were generated in strain IAM 13481 and screened for the inability to degrade patulin using a bioassay based on the sensitivity of Escherichia coli to patulin. Thirteen mutants showing reduced growth in the presence of patulin were isolated and further characterized. Genes disrupted in patulin-sensitive mutants included homologs of Saccharomyces cerevisiae YCK2, PAC2, DAL5, and VPS8. The patulin-sensitive mutants also exhibited hypersensitivity to reactive oxygen species as well as genotoxic and cell wall-destabilizing agents, suggesting that the inactivated genes are essential for tolerating and overcoming the initial toxicity of patulin. These results support a model whereby patulin degradation occurs through a multistep process that includes an initial tolerance to patulin that utilizes processes common to other external stresses, followed by two separate pathways for degradation.

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Bactericidal Effects of Aspergillus clavatus

Cited by 33 publications

References 0 publications

Overview on antibacterial metabolites from terrestrialAspergillusspp

Overview on antibacterial metabolites from terrestrialAspergillusspp

The Possible Mechanisms Involved in Degradation of Patulin by Pichia caribbica

Searching for Genes Responsible for Patulin Degradation in a Biocontrol Yeast Provides Insight into the Basis for Resistance to This Mycotoxin

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