Bacterien-haemagglutination

Adhesive Properties of Enterobacteriaceae

“…After Collier and de Miranda (1955) had observed that D -mannose, alone of many sugars, strongly inhibited an E. coli haemagglutinin, it was shown that the haemagglutinating activity of all group-I strains of E. coli, and that of similarly haemagglutinating strains of Shigella fiexneri, klebsiellae and salmonellae, was inhibited by small concentrations, e.g. 0.01-0.5% (w/v), of D-mannose, methyla-D-mannoside and yeast mannan (Duguid and Gillies, 1957;Duguid, 1959;Duguid et al, 1966) and a very few substances with molecular structures related to D-mannose (Old, 1972).…”

In vivo Evaluation of FimH Antagonists – A Novel Class of Antimicrobials for the Treatment of Urinary Tract Infection

“…[31] Modified binding properties could therefore explain the different outcome of the two in vivo experiments. Furthermore, methyl α-d-mannopyranoside (1) is a low affinity antagonist [32] and would probably require much higher concentrations for the high level of inoculation (up to 10 9 UPECs per mouse, [8] compared to 10 6 UPECs by Sharon and coworkers [7] ).…”

“…1. Timeline of the major steps of the development of antibiotics (top [4] ) and the FimH antiadhesion therapy for the treatment of UTI (bottom [5][6][7][8][9][10] ).…”

The mannose-specific lectin activity of Escherichia coli type 1 fimbriae assayed by agglutination of glycolipid-containing liposomes, erythrocytes, and yeast cells and hydrophobic interaction chromatography

“…Type 1 fimbriae are bacterial lectins, that are associated with increased adherence of the bacteria to different kinds of epithelial cells [1], phagocytes [2][3][4] and mucus [5]. The monosaccharide D-mannose inhibits adhesion mediated by type 1 fimbriae [6] suggesting that mannose residues on eukaryotic cell surfaces serve as receptor molecules [7].…”