Bacteriological profile and antimicrobial resistance pattern among patients with sepsis: A retrospective cohort study

Jain, Praneetha; Galiya, Azhaar; Philip, Sharon Luke; Mateti, Uday Venkat; Supriya, P.; Gudi, Sai Krishna; Shetty, Shraddha

doi:10.1111/ijcp.14701

Cited by 4 publications

(2 citation statements)

References 19 publications

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“…Thus, some indicators are needed to evaluate the clinical outcome. Previous investigations revealed that indicators like procalcitonin (PCT), age, intensive care unit (ICU) stay, malignancy, resistant bacterial infection, stroke, sex, diabetes mellitus, chronic renal failure, and previous use of antibiotics could indicate a poor prognosis of bloodstream infection ( Zhang et al., 2019 ; Blanchard et al., 2020 ; Barlas et al., 2021 ; Chen et al., 2021 ; Jain et al., 2021 ; Zduniak et al., 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Clinical Characteristics of Bloodstream Infection in Immunosuppressed Patients: A 5-Year Retrospective Cohort Study

Lin

Yang

Fang

et al. 2022

Front. Cell. Infect. Microbiol.

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IntroductionImmunosuppressed patients with bloodstream infection are at risk of mortality. Our objective was to assess the independent risk factors of bloodstream infection with mortality in immunosuppressive states.MethodsThe medical data of a total of 896 patients who were hospitalized in our hospital were collected from January 2015 to December 2019. Evaluation of the independent risk factors of mortality was done by univariate and multivariate logistic regression analyses.ResultsOf the 896 immunosuppressed patients with bloodstream infection, 698 had over 60-day survivals and 198 had 60-day mortality. In our study, PCT (mean ±; standard: 11.40 ±; 31.89 µg/l vs. 62.45 ±; 17.10 µg/l, p = 0.007) and presence of age >60 years (40% vs. 14.19%, p = 0.001) were significantly different between situations with and without 60-day survivals in both univariate and multivariate logistic regression analyses. Age >60 years and PCT could be used as indicators for bloodstream infection with 60-day death in immunosuppressive states; the OR (95% CI) were 1.532 (1.099–2.135) and 2.063 (1.413–3.013), respectively. In different subgroups, PCT and age were also independent risk factors of blood system diseases, Klebsiella pneumoniae infection, diabetes, and ICU-stay subgroups.ConclusionsAge and PCT were independently associated with mortality in immunosuppressive states, which may help to identify the highly risky situation of bloodstream infection in immunosuppressive states.

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Section: Introductionmentioning

confidence: 99%

Clinical Characteristics of Bloodstream Infection in Immunosuppressed Patients: A 5-Year Retrospective Cohort Study

Lin

Yang

Fang

et al. 2022

Front. Cell. Infect. Microbiol.

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“…16 Jain ve arkadaşları tarafından sepsis hastaları üzerinde yapılan bir çalışmada ise %32.8 oranında KNS'ler kan kültüründe tespit edilmiştir. 25 Bizim çalışmamızda da büyük çoğunlukla kan örneklerinde tanımladığımız KNS'lerin içinde S. haemolyticus türünün yaygınlığındaki artış dikkate alındığında bu patojene yönelik uygun tanı ve yönetim politikalarının üretilmesinin doğru bir yaklaşım olacağı görüşündeyiz. Ayrıca 2019 yılına göre KNS'lerin izolasyon sıklığında gözlemlediğimiz azalmanın 2020 ve 2021 yılında artan idrar örneklerine bağlı olarak üriner patojen izolasyon artması sonucu oluşan görece bir durum olduğunu düşünmekteyiz.…”

Section: Discussionunclassified

Niğde ilinde üçüncü basamak bir hastaneden izole edilen bakterilerin tür dağılımı ve antibiyotik duyarlılıkları: üç yıllık değerlendirme

Bozok

Öztürk²

2023

Mersin Üniversitesi Sağlık Bilimleri Dergisi

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Amaç: Artan bakteriyel enfeksiyonlar ve antimikrobiyal direnç (AMD) halk sağlığını tehdit etmektedir. Bu sorunun yönetiminde sürveyans çalışmaları büyük önem taşımaktadır. Bu çalışmada, çeşitli örneklerden izole edilen bakterilerin tür dağılımı ve antibiyotik duyarlılıklarının belirlenmesi amaçlanmıştır. Yöntem: Mart 2018- Mart 2021 tarihleri arasında … Hastanesi Tıbbi Mikrobiyoloji Laboratuvarı’na gönderilen klinik örneklerinden izole edilen bakterilerin tanımlama ve antibiyotik duyarlılık test (ADT) sonuçları retrospektif olarak incelendi. Bakteriyolojik tanımlama ve ADT’ler için Vitek 2 otomatik cihazı kullanıldı. İzolatların antibiyotik duyarlılıkları EUCAST standartlarına göre değerlendirildi. Bulgular: Belirtilen tarih aralığında farklı klinik örneklerden toplam 6392 bakteriyel patojen izole edildi ve 6039 (%94.5) bakteri izolatına ADT yapıldı. Üreme tespit edilen örnek türleri arasında en sık idrar örneği (n=2982; %47.1) olmak üzere sırasıyla kan (n=1492; %23.6), trakeal aspirat (n=871; %13.8), yara (n=476; %7.5), balgam (n=154; %2.4) ve diğer klinik örnekler bunu takip etti. En sık tespit edilen bakteri türünün Esherichia coli (%28.4) olduğu görüldü. Genişlemiş spektrumlu beta-laktamaz (ESBL) pozitifliği E. coli için %22.6 ve Klebsiella spp. için %14.8 olarak bulundu. Staphylococcus aureus türleri içinde metisiline dirençli S. aureus (MRSA) oranı %45.6 olarak bulundu. Sonuç: Enfeksiyon hastalıkları ile mücadelede bölgesel bakteriyel etken ve antimikrobiyal direnç profilinin iyi bilinmesi ve sürveyans sistemlerinin doğru işletilmesi gerekmektedir. E. coli ve Klebsiella spp. türlerindeki artışa karşı önlem olarak ampirik tedavilerin yeniden gözden geçirilmesi yararlı olacaktır. Yüksek MRSA ve ESBL oranları bölgemizi tehdit edici bir unsur olmaya devam etmektedir.

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Clinical presentation and antimicrobial resistance of invasive Escherichia coli disease in hospitalized older adults: a prospective multinational observational study

Doua,

Rodríguez-Baño,

Froget

et al. 2024

Infection

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Background Clinical data characterizing invasive Escherichia coli disease (IED) are limited. We assessed the clinical presentation of IED and antimicrobial resistance (AMR) patterns of causative E. coli isolates in older adults. Methods EXPECT-2 (NCT04117113) was a prospective, observational, multinational, hospital-based study conducted in patients with IED aged ≥ 60 years. IED was determined by the microbiological confirmation of E. coli from blood; or by the microbiological confirmation of E. coli from urine or an otherwise sterile body site in the presence of requisite criteria of systemic inflammatory response syndrome (SIRS), Sequential Organ Failure Assessment (SOFA), or quick SOFA (qSOFA). The primary outcomes were the clinical presentation of IED and AMR rates of E. coli isolates to clinically relevant antibiotics. Complications and in-hospital mortality were assessed through 28 days following IED diagnosis. Results Of 240 enrolled patients, 80.4% had bacteremic and 19.6% had non-bacteremic IED. One-half of infections (50.4%) were community-acquired. The most common source of infection was the urinary tract (62.9%). Of 240 patients, 65.8% fulfilled ≥ 2 SIRS criteria, and 60.4% had a total SOFA score of ≥ 2. Investigator-diagnosed sepsis and septic shock were reported in 72.1% and 10.0% of patients, respectively. The most common complication was kidney dysfunction (12.9%). The overall in-hospital mortality was 4.6%. Of 299 E. coli isolates tested, the resistance rates were: 30.4% for trimethoprim-sulfamethoxazole, 24.1% for ciprofloxacin, 22.1% for levofloxacin, 16.4% for ceftriaxone, 5.7% for cefepime, and 4.3% for ceftazidime. Conclusions The clinical profile of identified IED cases was characterized by high rates of sepsis. IED was associated with high rates of AMR to clinically relevant antibiotics. The identification of IED can be optimized by using a combination of clinical criteria (SIRS, SOFA, or qSOFA) and culture results.

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Bacteriological profile and antimicrobial resistance pattern among patients with sepsis: A retrospective cohort study

Cited by 4 publications

References 19 publications

Clinical Characteristics of Bloodstream Infection in Immunosuppressed Patients: A 5-Year Retrospective Cohort Study

Clinical Characteristics of Bloodstream Infection in Immunosuppressed Patients: A 5-Year Retrospective Cohort Study

Niğde ilinde üçüncü basamak bir hastaneden izole edilen bakterilerin tür dağılımı ve antibiyotik duyarlılıkları: üç yıllık değerlendirme

Clinical presentation and antimicrobial resistance of invasive Escherichia coli disease in hospitalized older adults: a prospective multinational observational study

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