Bacteriophage Interactions With Epithelial Cells: Therapeutic Implications

Górski, Andrzej; Borysowski, Jan; Międzybrodzki, Ryszard

doi:10.3389/fmicb.2020.631161

Cited by 19 publications

(17 citation statements)

References 32 publications

(22 reference statements)

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“…In summary, the effect of bacteriophages on the induction of cytokine responses may depend on many factors: first, the level of purification of the preparation from LPS, which is an extremely potent stimulator of the immune response. However, other factors such as type of bacteriophage, the route of administration, the length of treatment, and the production of anti-phage antibodies should be taken into consideration [100].…”

Section: Phage-induced Cytokine Responsementioning

confidence: 99%

Interactions of Bacteriophages with Animal and Human Organisms—Safety Issues in the Light of Phage Therapy

Podlacha

Grabowski

Kosznik-Kawśnicka

et al. 2021

IJMS

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Bacteriophages are viruses infecting bacterial cells. Since there is a lack of specific receptors for bacteriophages on eukaryotic cells, these viruses were for a long time considered to be neutral to animals and humans. However, studies of recent years provided clear evidence that bacteriophages can interact with eukaryotic cells, significantly influencing the functions of tissues, organs, and systems of mammals, including humans. In this review article, we summarize and discuss recent discoveries in the field of interactions of phages with animal and human organisms. Possibilities of penetration of bacteriophages into eukaryotic cells, tissues, and organs are discussed, and evidence of the effects of phages on functions of the immune system, respiratory system, central nervous system, gastrointestinal system, urinary tract, and reproductive system are presented and discussed. Modulations of cancer cells by bacteriophages are indicated. Direct and indirect effects of virulent and temperate phages are discussed. We conclude that interactions of bacteriophages with animal and human organisms are robust, and they must be taken under consideration when using these viruses in medicine, especially in phage therapy, and in biotechnological applications.

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Section: Phage-induced Cytokine Responsementioning

confidence: 99%

Interactions of Bacteriophages with Animal and Human Organisms—Safety Issues in the Light of Phage Therapy

Podlacha

Grabowski

Kosznik-Kawśnicka

et al. 2021

IJMS

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“…The question of whether orally administered phages can bypass the intestinal epithelium and migrate to lymph, peripheral blood, and internal organs is equally important, especially from a clinical perspective in patients with alcohol-associated hepatitis [ 27 ]. The oral administration of a phage cocktail against cytolytic E. faecalis followed by ethanol binge led to a consistent recovery of live phages from serum, spleen, liver, and feces.…”

Section: Discussionmentioning

confidence: 99%

Immune Response of an Oral Enterococcus faecalis Phage Cocktail in a Mouse Model of Ethanol-Induced Liver Disease

Mendes

Duan

Schnabl

2022

Viruses

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Cytolysin-positive Enterococcus faecalis (E. faecalis) cause more severe alcohol-associated hepatitis, and phages might be used to specifically target these bacteria in a clinical trial. Using a humanized mouse model of ethanol-induced liver disease, the effect of cytolytic E. faecalis phage treatment on the intestinal and liver immune response was evaluated. The observed immune response was predominantly anti-inflammatory and tissue-restoring. Besides, live phages could be readily recovered from the serum, spleen, and liver following oral gavage in ethanol-fed mice. We also isolated 20 new phages from the sewage water; six of them exhibited a relatively broad host range. Taken together, the oral administration of cytolytic E. faecalis phages leads to the translocation of phages to the systemic circulation and appears to be safe, following chronic-binge ethanol administration. A cocktail of three phages covers the majority of tested cytolysin-positive E. faecalis strains and could be tested in a clinical trial.

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“…Furthermore, evidence of direct interaction between the immune system and bacteriophages is accumulating. For example, evidence suggests that Phage plays a critical role in reducing ROS production by phagocytic cells, altering the expression of cell surface markers, inhibiting immune cell migration, and modulating cytokine secretion ( Górski et al, 2021 ). Various in vitro and in vivo studies suggest that Phage's anti-inflammatory activity is primarily governed by interference with the expression of the nuclear transcription factor NF-kappa B ( Górski et al, 2016 ).…”

Section: Phage Therapy As a Promising Candidate For The Treatment Of ...mentioning

confidence: 99%

Phage therapy in the Covid-19 era: Advantages over antibiotics

Khan

Toleti

Joshi

2022

Current Research in Microbial Sciences

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Bacteriophage Interactions With Epithelial Cells: Therapeutic Implications

Cited by 19 publications

References 32 publications

Interactions of Bacteriophages with Animal and Human Organisms—Safety Issues in the Light of Phage Therapy

Interactions of Bacteriophages with Animal and Human Organisms—Safety Issues in the Light of Phage Therapy

Immune Response of an Oral Enterococcus faecalis Phage Cocktail in a Mouse Model of Ethanol-Induced Liver Disease

Phage therapy in the Covid-19 era: Advantages over antibiotics

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