Baicalein: A review on its anti‐cancer effects and mechanisms in lung carcinoma

Naveenkumar, Chandrashekar; Anandakumar, Pandi

doi:10.1111/jfbc.14230

Cited by 25 publications

(10 citation statements)

References 67 publications

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“…Baicalein, a flavonoid extracted from the roots of Scutellaria baicalensis , has demonstrated substantial anti-tumor activity in recent in vivo and in vitro experiments, showing particular preventive and therapeutic effects on NSCLC ( 198 ). It has a wide anticancer spectrum, affects multiple cellular actions, and exhibits complex and diverse mechanisms, including the regulation of cell proliferation, metastasis, apoptosis, and autophagy ( 199 ).…”

Section: Effects Of Four Natural Products Regulating Autophagy and Ap...mentioning

confidence: 99%

Natural products targeting autophagy and apoptosis in NSCLC: a novel therapeutic strategy

Qin,

Li,

et al. 2024

Front. Oncol.

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Lung cancer is the leading cause of cancer-related mortality worldwide, with non-small cell lung cancer (NSCLC) being the predominant type. The roles of autophagy and apoptosis in NSCLC present a dual and intricate nature. Additionally, autophagy and apoptosis interconnect through diverse crosstalk molecules. Owing to their multitargeting nature, safety, and efficacy, natural products have emerged as principal sources for NSCLC therapeutic candidates. This review begins with an exploration of the mechanisms of autophagy and apoptosis, proceeds to examine the crosstalk molecules between these processes, and outlines their implications and interactions in NSCLC. Finally, the paper reviews natural products that have been intensively studied against NSCLC targeting autophagy and apoptosis, and summarizes in detail the four most retrieved representative drugs. This paper clarifies good therapeutic effects of natural products in NSCLC by targeting autophagy and apoptosis and aims to promote greater consideration by researchers of natural products as candidates for anti-NSCLC drug discovery.

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Section: Effects Of Four Natural Products Regulating Autophagy and Ap...mentioning

confidence: 99%

Natural products targeting autophagy and apoptosis in NSCLC: a novel therapeutic strategy

Qin,

Li,

et al. 2024

Front. Oncol.

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“…In NSCLC (Non-small cell lung cancer) cells, Baicalein therapy activates AMPKα/MEK/ERK1/2 signaling cascades by triggering phosphorylation, which cross-talks between FOXO3a and RUNX3 (RUNX family transcription factor 3) [ 25 ]. Additionally, Baicalein treatment reduces the expression of Caveolin-1 (cav-1) in prostate cancer cells, DU145, and PC-3 cells, resulting in the downregulation of AKT and mTOR levels.…”

Section: Cell-signaling Molecular Mechanisms Of Baicalein For Cancer ...mentioning

confidence: 99%

“…Additionally, Baicalein prevented the growth of various chemotherapy cancers in mouse models [ 25 ]. When used in conjunction with chemotherapy, Baicalein could be established as a novel anti-cancer medication to treat cancers [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Baicalein as Promising Anticancer Agent: A Comprehensive Analysis on Molecular Mechanisms and Therapeutic Perspectives

Morshed

Paul

Hossain

et al. 2023

Cancers

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Despite significant therapeutic advancements for cancer, an atrocious global burden (for example, health and economic) and radio- and chemo-resistance limit their effectiveness and result in unfavorable health consequences. Natural compounds are generally considered safer than synthetic drugs, and their use in cancer treatment alone, or in combination with conventional therapies, is increasingly becoming accepted. Interesting outcomes from pre-clinical trials using Baicalein in combination with conventional medicines have been reported, and some of them have also undergone clinical trials in later stages. As a result, we investigated the prospects of Baicalein, a naturally occurring substance extracted from the stems of Scutellaria baicalensis Georgi and Oroxylum indicum Kurz, which targets a wide range of molecular changes that are involved in cancer development. In other words, this review is primarily driven by the findings from studies of Baicalein therapy in several cancer cell populations based on promising pre-clinical research. The modifications of numerous signal transduction mechanisms and transcriptional agents have been highlighted as the major players for Baicalein’s anti-malignant properties at the micro level. These include AKT serine/threonine protein kinase B (AKT) as well as PI3K/Akt/mTOR, matrix metalloproteinases-2 & 9 (MMP-2 & 9), Wnt/-catenin, Poly(ADP-ribose) polymerase (PARP), Mitogen-activated protein kinase (MAPK), NF-κB, Caspase-3/8/9, Smad4, Notch 1/Hes, Signal transducer and activator of transcription 3 (STAT3), Nuclear factor erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein-1 (Keap 1), Adenosine monophosphate-activated protein kinase (AMPK), Src/Id1, ROS signaling, miR 183/ezrin, and Sonic hedgehog (Shh) signaling cascades. The promise of Baicalein as an anti-inflammatory to anti-apoptotic/anti-angiogenic/anti-metastatic medicinal element for treating various malignancies and its capability to inhibit malignant stem cells, evidence of synergistic effects, and design of nanomedicine-based drugs are altogether well supported by the data presented in this review study.

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“…Additionally, wogonin has been reported to inhibit HCC proliferation by affecting nuclear factor kappa B (NF-κB)/B-cell lymphoma 2 (Bcl-2), epidermal growth factor receptor (EGFR) and the EGFR downstream ERK/AKT signal pathway[ 5 ]. Furthermore, baicalein has been reported to inhibit cancer progression by inducing autophagy, apoptosis and cell cycle arrest in HCC cell lines[ 34 ]. Similarly, the long non-coding RNAs (lncRNAs)-hsa-miR-4443-AKT1 pathway responds positively to baicalein treatment[ 35 ].…”

Section: Augmented Local Controlmentioning

confidence: 99%

Roles of conventional and complementary therapies in recurrent hepatocellular carcinoma

Lai¹,

Lin²,

Jeng³

et al. 2023

World J Gastrointest Oncol

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Hepatocellular carcinoma (HCC) is the fifth most common type of cancer and the fourth leading cause of cancer-related deaths in the world. HCC has a reported recurrence rate of 70%-80% after 5 years of follow-up. Controlling tumor recurrence is the most critical factor associated with HCC mortality. Conventional salvage therapies for recurrent HCC include re-hepatectomy or liver transplantation, transcatheter arterial chemoembolization, Y-90, target therapy, and immunotherapy; however, these conventional treatment modalities have yet to achieve consistently favorable outcomes. Meanwhile, previous studies have demonstrated that conventional therapies in combination with traditional Chinese medicine (TCM), acupuncture, moxibustion or dietary supplements could notably benefit patients with HCC recurrence by strengthening and augmenting the overall management strategy. However, systemic reviews related to the interactions between complementary therapies and conventional therapy in recurrent HCC are limited. In this review, we discuss the molecular mechanisms underlying the functions of complementary therapies for recurrent HCC, which include augmenting the local control to improve the congestion status of primary tumors and reducing multicentric tumor occurrence via inducing autophagy, apoptosis or cell cycle arrest. TCM and its derivatives may play important roles in helping to control HCC recurrence by inhibiting epithelial-mesenchymal transition, migration, invasion, and metastasis, inhibiting cancer stem cells, and ameliorating drug resistance.

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Baicalein: A review on its anti‐cancer effects and mechanisms in lung carcinoma

Cited by 25 publications

References 67 publications

Natural products targeting autophagy and apoptosis in NSCLC: a novel therapeutic strategy

Natural products targeting autophagy and apoptosis in NSCLC: a novel therapeutic strategy

Baicalein as Promising Anticancer Agent: A Comprehensive Analysis on Molecular Mechanisms and Therapeutic Perspectives

Roles of conventional and complementary therapies in recurrent hepatocellular carcinoma

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