Baicalein protects rat brain mitochondria against chronic cerebral hypoperfusion-induced oxidative damage

He, Xiaoli; Wang, Yuehua; Gao, Mei; Li, Xiaoxiu; Zhang, Tiantai; Du, Guanhua

doi:10.1016/j.brainres.2008.10.005

Cited by 62 publications

(43 citation statements)

References 39 publications

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“…The hippocampus of brain is very sensitive to ischemia and plays an important role in memory and learning. Similar to previous studies [16,18,[24][25]. 2VO rats demonstrated spatial memory and learning impairment on MWM tasks in this study.…”

Section: Discussionsupporting

confidence: 92%

Improved spatial learning and memory performance following Tualang honey treatment during cerebral hypoperfusion-induced neurodegeneration

Saxena¹,

Phyu²,

Al-Ani³

et al. 2016

J Transl Sci

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Honey has shown potential therapeutic properties in traditional medicine. This study investigated the cognition enhancing potential of Tualang honey in chronic cerebral hypoperfusion-induced neurodegeneration by permanent bilateral common carotid arteries ligation (2 vessels occlusion-2VO) in rats. Previous studies have shown that rats subjected to 2VO (2 vessel occlusion) experienced cognitive deficits, oxidative stress and neuronal injury in the hippocampus of the brain. We studied the effect of Tualang honey on learning and memory using the Morris water maze (MWM) in rats. Rats were randomly divided into four groups (n=10); Sham control, untreated 2VO (2VO), honey treated 2VO (2VO+H) and honey treated group (H). Each group was again divided into two subgroups (n=5): one for long term memory assessment and another for short term memory and relearning tasks. After 10 weeks of treatment, all rat groups were tested for cognitive assessment by MWM (Morris water maze). 2VO+H rats had better spatial learning and memory performance than untreated 2VO rats in MWM tasks (p<0.05). However, there was no significant difference between Sham rats and H group rats (p>0.05). This study shows that Malaysian Tualang honey might have therapeutic potential for the treatment of chronic cerebral hypoperfusion related neurodegenerative disorders such as Alzheimer's disease (AD) in which cognitive impairment is profound.

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Section: Discussionsupporting

confidence: 92%

Improved spatial learning and memory performance following Tualang honey treatment during cerebral hypoperfusion-induced neurodegeneration

Saxena¹,

Phyu²,

Al-Ani³

et al. 2016

J Transl Sci

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“…There are several mechanisms leading to neuronal injury and death after insufficient CBF. Previous studies showed that oxidative stress plays a key role in chronic cerebral hypoperfusion 11,12 . Nevertheless, other mechanisms including glutamatemediated excitotoxicity, acidotoxicity, and inflammation are thought to participate in the process of neuronal injury 13 .…”

Section: Introductionmentioning

confidence: 99%

Ceftriaxone improves spatial learning and memory in chronic cerebral hypoperfused rats

Koomhin¹,

Tilokskulchai²,

Tapechum

2012

ScienceAsia

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Cerebral hypoperfusion is associated with cognitive decline in ageing, mild cognitive impairment, vascular type dementia, and Alzheimer's disease. The mechanisms leading to such neurological impairments are still uncertain. Although several mechanisms have been proposed as contributing factors leading to neuronal injury, glutamate excitotoxicity seems to be the relevant one. Recently, it was found that β-lactam antibiotics such as ceftriaxone show a neuroprotective effect by upregulation of glutamate transporter and reduction of glutamate excitotoxicity. To study the contribution of glutamate excitotoxicity and the effects of ceftriaxone on spatial learning and memory in chronic cerebral hypoperfusion, we conducted experiments in rats subjected to permanent bilateral common carotid artery occlusion. Ceftriaxone (200 mg/kg) was injected daily in rats for 5 days after the onset of the arterial ligation. A Morris water maze was used to assess learning and memory two months after arterial ligation. Hippocampal histology and glutamate transporter 1 (GLT-1) expression were also studied. Results showed that ceftriaxone improved learning and memory performance. Consistently, the histological study showed an increase hippocampal CA1 and CA3 neuronal numbers in the ceftriaxone-treated group compared with the vehicle-treated group. Although not statistically significant, the GLT-1 protein level in the hippocampus was 86% higher than the sham group. We conclude that ceftriaxone treatment can attenuate neuronal injury and improve spatial learning and memory after chronic cerebral hypoperfusion and that glutamate excitotoxicity may play an important role in the pathophysiology of chronic cerebral hypoperfusion.

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“…Baicalein is known to have a neuroprotective effect against MPTP (1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine) neurotoxicity (Cheng et al 2008). The flavone protects rat brain mitochondria against chronic cerebral hyperfusion-induced oxidative damage (He et al 2009). Its glucoside, baicalin, is a potent anti-inflammatory and antitumor agent (Chang et al 2002;Woo et al 2006;Shang et al 2010).…”

Section: Introductionmentioning

confidence: 99%

The effect of cytokinins on shoot proliferation, secondary metabolite production and antioxidant potential in shoot cultures of Scutellaria alpina

Grzegorczyk-Karolak

Kuźma

Wysokińska

2015

Plant Cell Tiss Organ Cult

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The present study evaluates the effects of various cytokinins on Scutellaria alpina shoot proliferation and production of polyphenolic metabolites (baicalin, wogonoside, luteolin, luteolin 7-O-glucoside, verbascoside). The shoots were induced from shoot tips on MS medium supplemented with IAA (indole-3-acetic acid, 0.57 lM) and various concentrations of 6-benzylaminopurine (BAP), kinetin, zeatin (1, 2, 4, 8 lM) or tidiazuron (TDZ) (0.2, 0.5, 1 lM). Among the cytokinins tested, BAP was the most effective for shoot induction, and the highest number of shoots (25 per explant) was achieved with 2 and 4 lM BAP. Maximum biomass production was also achieved on these media. Significantly higher baicalin, wogonoside and verbascoside contents were recorded in treatments containing cytokinins combined with 0.57 lM IAA, when compared to cytokinin-free medium. TDZ at a concentration of 0.5 lM was the most effective for polyphenol production. However, supplementation with cytokinins often results in the reduction of luteolin and its 7-O-glucoside production in the shoot culture of S. alpina. ABTS [2,20 -azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)] and ferric reducing antioxidant power assays were used to identify the antioxidant potential of methanolic extracts from shoots cultured in the presence of different types and concentrations of cytokinins. In both tests, the shoots from medium supplemented with 0.5 lM TDZ demonstrated the strongest antioxidant activity. The results indicate that higher polyphenolic content correlated with greater reducing power and antiradical efficiency.

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Baicalein protects rat brain mitochondria against chronic cerebral hypoperfusion-induced oxidative damage

Cited by 62 publications

References 39 publications

Improved spatial learning and memory performance following Tualang honey treatment during cerebral hypoperfusion-induced neurodegeneration

Improved spatial learning and memory performance following Tualang honey treatment during cerebral hypoperfusion-induced neurodegeneration

Ceftriaxone improves spatial learning and memory in chronic cerebral hypoperfused rats

The effect of cytokinins on shoot proliferation, secondary metabolite production and antioxidant potential in shoot cultures of Scutellaria alpina

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