Baixa dose de methotrexate comparado a placebo em osteoartrite de joelho

Holanda, Haroldo Tenório de; Pollak, Daniel Feldman; Pucinelli, Mário Luis Cardoso

doi:10.1590/s0482-50042007000500008

Cited by 16 publications

(8 citation statements)

References 13 publications

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“…However, there was no significant improvement in physical function after the third month as compared to six month after treatment. In Holanda et al’s study (13) there was no significant difference between the two groups in terms of the WOMAC score. In contrast, the researchers observed a significant decrease in overall score and in both pain and physical function subscales following treatment with MTX.…”

Section: Discussionmentioning

confidence: 81%

“…Wenham et al (15) in their study on 30 patients with knee OA treated with an initial dose of weekly MTX 7.5 mg and subsequent increase up to 20 mg weekly for 24 weeks, showed a significant pain reduction in almost 60% of the patients, while in 13% of the patients, the symptoms were worsened. Unlike these studies, Holanda et al (13) found no statistically significant difference in pain intensity based on VAS between patients treated with 7.5 mg MTX weekly or placebo.…”

Section: Discussionmentioning

confidence: 87%

“…The researchers found no significant difference in the number of NSAIDs used between the two groups, although there was a lower tendency for consumption in the MTX group. Holand and colleagues (13) also did not report any significant differences between MTX and placebo groups in terms of paracetamol consumption, although there was a tendency to consume more paracetamol in the placebo group.…”

Section: Discussionmentioning

confidence: 92%

“…Methotrexate (MTX) is an effective and commonly used disease-modifying agent for inflammatory arthritis with favorable long-term results (12). A few studies have addressed low-dose MTX in OA (13-15), each with different outcomes. Considering the effects of MTX in the treatment of inflammatory arthritis and the role of inflammation in OA, it seems that MTX use in the treatment would be beneficial.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of Methotrexate on Pain Severity Reduction and Improvement of Quality of Life in Patients with Moderate to Severe Knee Osteoarthritis

et al. 2019

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Background Knee osteoarthritis (OA) leads to low quality of life due to pain and limitation in daily activities. Recent studies indicated that Methotrexate (MTX) could reduce pain due to its anti-inflammatory effects. Objectives In this study, the researchers aimed at evaluating the efficacy of MTX in pain control and improvement of quality of life in patients with moderate to severe knee OA. Methods In this randomized clinical trial, 100 patients with moderate to severe knee OA were allocated to receive MTX (n = 50) 7.5 mg weekly to be increased to 15 mg weekly after first months or placebo (n = 50) for six months. Pain severity was measured using the numerical rating scale (NRS), so was functional status by Western Ontario and McMaster Universities Arthritis Index (WOMAC) and quality of life by SF-12 questionnaire before the treatment, and three months and six months after the intervention. The results were compared between the groups subsequently. Nine patients from the MTX group were excluded due to the use of corticosteroids during the treatment period. Results The MTX group compared to the placebo group had significant improvement in pain severity and quality of life during six months and WOMAC parameters at three and six months after the intervention. The need for NSAIDS was slightly higher in the placebo group with no significant difference (22% versus 36%, P = 0.14). The MTX adverse effects were not observed. Conclusions Treatment of moderate to severe knee OA with MTX could reduce pain severity and improve functional status and quality of life in OA patients.

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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Efficacy of Methotrexate on Pain Severity Reduction and Improvement of Quality of Life in Patients with Moderate to Severe Knee Osteoarthritis

et al. 2019

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“…Somente o GPC MALAYSIA (2013) recomenda a glucosamina, na dose de 1500mg/dia, para o alívio da dor e reforça que os resultados do uso devem ser avaliados após 3 meses de uso, mas afirma que a eficácia da condroitina é incerta (59). (207)(208)(209).…”

Section: Osteoartriteunclassified

Matriz de recomendações para farmacoterapia da osteoporose e da osteoartrite: recurso para subsidiar a adaptação de guias de prática clínica

Wainberg¹

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Agradeço a todos os meus familiares e amigos, que me ajudaram nesta caminhada, pelo apoio, paciência, carinho, amor e compreensão para comigo nos momentos felizes e complicados. Pessoas que não permitiram que eu desistisse e me ajudaram a chegar até o final da jornada. Agradeço aos meus filhos, Amir e Thaly, sempre ao meu lado, pelo amparo, incentivo e apoio incondiconal. Agradeço à minha orientadora Professora Dra. Eliane Ribeiro, pela paciência, incentivo e empenho. Meus sinceros agradecimentos à Profa.

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Inflammation as a therapeutic target for osteoarthritis: A literature review of clinical trials

Zhu,

Fang,

Wang

et al. 2024

Clin Rheumatol

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The burden of osteoarthritis (OA) is rapidly increasing with population aging, but there are still no approved disease-modifying drugs available. Accumulating evidence has shown that OA is a heterogeneous disease with multiple phenotypes, and it is unlikely to respond to one-size-fits-all treatments. Inflammation is recognized as an important phenotype of OA and is associated with worse pain and joint deterioration. Therefore, it is believed that anti-inflammatory treatments may be more effective for OA with an inflammatory phenotype. In this review, we summarized clinical trials that evaluated anti-inflammatory treatments for OA and discussed whether these treatments are more effective in inflammatory OA phenotypes compared to general OA patients.

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Baixa dose de methotrexate comparado a placebo em osteoartrite de joelho

Cited by 16 publications

References 13 publications

Efficacy of Methotrexate on Pain Severity Reduction and Improvement of Quality of Life in Patients with Moderate to Severe Knee Osteoarthritis

Efficacy of Methotrexate on Pain Severity Reduction and Improvement of Quality of Life in Patients with Moderate to Severe Knee Osteoarthritis

Matriz de recomendações para farmacoterapia da osteoporose e da osteoartrite: recurso para subsidiar a adaptação de guias de prática clínica

Inflammation as a therapeutic target for osteoarthritis: A literature review of clinical trials

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