Balancing act: BRCA2's elaborate management of telomere replication through control of G‐quadruplex dynamicity
So Young Joo,
Keewon Sung,
Hyunsook Lee
Abstract:In billion years of evolution, eukaryotes preserved the chromosome ends with arrays of guanine repeats surrounded by thymines and adenines, which can form stacks of four‐stranded planar structure known as G‐quadruplex (G4). The rationale behind the evolutionary conservation of the G4 structure at the telomere remained elusive. Our recent study has shed light on this matter by revealing that telomere G4 undergoes oscillation between at least two distinct folded conformations. Additionally, tumor suppressor BRCA… Show more
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