Balancing selection and recombination drive genetic variation at MHC class I genes in the giant panda

Yu, Fang-Jian; Zhu, Ying; Xiong, Tie-Yi; Wan, Qiu‐Hong; Zhang, Hemin

doi:10.1007/s11434-014-0686-7

Cited by 5 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The occurrence of multiple MHC DRB loci varying in the number of loci between individuals and species was reported in Neotropical bat species such as C. perspicillata (three DRB loci), S. bilineata (ten DRB loci) [35], A. jamaicensis (three DRB loci) [38], as well as in other animals [1, 7, 85, 86]. Together with environmental and biological patterns, gene conversion and recombination processes are known to drive the extensive MHC polymorphism [18, 87]. …”

Section: Discussionmentioning

confidence: 99%

“…Sexual selection pressures encompass mechanisms such as maternal–fetal interactions [11] and mate selection [12]. However, when assessing the genetic variability of both neutral markers and MHC genes, studies have highlighted the role of past demographic processes (e.g., fragmentation, bottlenecks, geographic isolation) in shaping the pattern of MHC variability that can sometimes surpass that of natural selection [13–18]. …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Spatial pattern of genetic diversity and selection in the MHC class II DRB of three Neotropical bat species

et al. 2016

View full text Add to dashboard Cite

BackgroundAlthough bats are natural reservoirs of many pathogens, few studies have been conducted on the genetic variation and detection of selection in major histocompatibility complex (MHC) genes. These genes are critical for resistance and susceptibility to diseases, and host–pathogen interactions are major determinants of their extensive polymorphism. Here we examined spatial patterns of diversity of the expressed MHC class II DRB gene of three sympatric Neotropical bats, Carollia perspicillata and Desmodus rotundus (Phyllostomidae), and Molossus molossus (Molossidae), all of which use the same environments (e.g., forests, edge habitats, urban areas). Comparison with neutral marker (mtDNA D-loop) diversity was performed at the same time.ResultsTwenty-three DRB alleles were identified in 19 C. perspicillata, 30 alleles in 35 D. rotundus and 20 alleles in 28 M. molossus. The occurrence of multiple DRB loci was found for the two Phyllostomidae species. The DRB polymorphism was high in all sampling sites and different signatures of positive selection were detected depending on the environment. The patterns of DRB diversity were similar to those of neutral markers for C. perspicillata and M. molossus. In contrast, these patterns were different for D. rotundus for which a geographical structure was highlighted. A heterozygote advantage was also identified for this species. No recombination or gene conversion event was found and phylogenetic relationships showed a trans-species mode of evolution in the Phyllostomids.ConclusionsThis study of MHC diversity demonstrated the strength of the environment and contrasting pathogen pressures in shaping DRB diversity. Differences between positively selected sites identified in bat species highlighted the potential role of gut microbiota in shaping immune responses. Furthermore, multiple geographic origins and/or population admixtures observed in C. perspicillata and M. molossus populations acted as an additional force in shaping DRB diversity. In contrast, DRB diversity of D. rotundus was shaped by environment rather than demographic history.Electronic supplementary materialThe online version of this article (doi:10.1186/s12862-016-0802-1) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Spatial pattern of genetic diversity and selection in the MHC class II DRB of three Neotropical bat species

et al. 2016

View full text Add to dashboard Cite

show abstract

“…This special issue focuses on diverse hot topics in conservational biology including the influence of China's economic development on giant panda [72], factors that affect the natural regeneration of arrow bamboo in giant panda habitat [73], ranging pattern and population composition of Rhinopithecus bieti in Tibet [74], impacts of grassland fence on the behavior and habitat area of the Przewalski's gazelle [75]. Several questions in adaptive evolution were also addressed at molecular level, from the natural selection of leptin [76], variation and trans-species polymorphism MHC [77,78], to the molecular phylogenetic analysis of mitochondrial gene fragments in Chinese viviparid genus Margarya [79].…”

Section: Evolution and Conservative Biologymentioning

confidence: 99%

From Chinese Science Bulletin to Science Bulletin: celebrate the coming 50th birthday

Jia

Chen

2015

Science Bulletin

View full text Add to dashboard Cite

Polymorphism analysis of major histocompatibility complex (MHC) DQB gene in the Asiatic black bear (Ursus thibetanus)

Jia

et al. 2023

Mamm Res

View full text Add to dashboard Cite

Balancing selection and recombination drive genetic variation at MHC class I genes in the giant panda

Cited by 5 publications

References 8 publications

Spatial pattern of genetic diversity and selection in the MHC class II DRB of three Neotropical bat species

Spatial pattern of genetic diversity and selection in the MHC class II DRB of three Neotropical bat species

From Chinese Science Bulletin to Science Bulletin: celebrate the coming 50th birthday

Polymorphism analysis of major histocompatibility complex (MHC) DQB gene in the Asiatic black bear (Ursus thibetanus)

Contact Info

Product

Resources

About