Low density signature orthogonal frequency division multiplexing (LDS-OFDM) is an uplink multi-carrier multiple access scheme that uses low density signatures (LDS) for spreading the symbols in the frequency domain. In this paper, we introduce an effective receiver for the LDS-OFDM scheme. We propose a framework to analyze and design this iterative receiver using extrinsic information transfer (EXIT) charts. Furthermore, a turbo multiuser detector/decoder (MUDD) is proposed for the LDS-OFDM receiver. We show how the turbo MUDD is tuned using EXIT charts analysis. By tuning the turbo-style processing, the turbo MUDD can approach the performance of optimum MUDD with a smaller number of inner iterations. Using the suggested design guidelines in this paper, we show that the proposed structure brings about 2.3 dB performance improvement at a bit error rate (BER) equal to 10 −5 over conventional LDS-OFDM while keeping the complexity affordable. Simulations for different scenarios also show that the LDS-OFDM outperforms similar well-known multiple access techniques such as multi-carrier code division multiple access (MC-CDMA) and group-orthogonal MC-CDMA.