Band neutrophil count and the presence and severity of coronary atherosclerosis

Kawaguchi, Hiroshi; Mori, Tsukasa; Kawano, Teruaki; Kono, Suminori; Sasaki, Jun; Arakawa, Kikuo

doi:10.1016/s0002-8703(96)90384-1

Cited by 83 publications

(56 citation statements)

References 21 publications

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“…Contrary to prior studies (5,(23)(24)(25), in our study WBC and neutrophil counts did not differ significantly between SYNTAX scores groups (1-22, 23-32, >32), although their counts were relatively high in moderate and high score groups. Our data showed similar findings with prior studies when assessing WBC and neutrophil count between CAD (-) and CAD(+) groups.…”

Section: Discussioncontrasting

confidence: 99%

“…Hastalar KAH olan ve olmayan şeklinde iki gruba ayrıldı. KAH grubu SYNTAX skoruna göre Avrupa Kardiyoloji Cemiyeti miyokardiyal girişim kılavuzuna dayanarak 3 gruba ayrıldı (23)(24)(25)(26)(27)(28)(29)(30)(31)(32) >32). İstatistiksel analiz Mann-Whitney U ve Kruskal-Wallis testleri ile yapıldı, ayrıca KAH karmaşıklığının bağımsız öngördürücüle-rini belirlemek amacı ile çoklu lojistik regresyon analizi kullanıldı.…”

Section: Original Investigation öZgün Araşt›rma 662unclassified

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Relation of neutrophil -to- lymphocyte ratio with the presence and complexity of coronary artery disease: an observational study

Sönmez

Ertaş²,

Bacaksız³

et al. 2013

Anadolu Kardiyol Derg

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Objective: The neutrophil -to-lymphocyte ratio (NLR) is a new predictor for cardiovascular risk and mortality. The SYNTAX score is an angiographic tool used in grading the complexity of coronary artery disease (CAD). However, its relation with CAD severity and complexity is not yet known. We hypothesized that NLR would be associated with a greater complexity of CAD as assessed using the SYNTAX score. Methods: This cross-sectional observational study included 106 patients who had undergone coronary angiography for stable angina pectoris and 69 patients who had normal coronary angiogram. Baseline NLR was measured by dividing neutrophil count to lymphocyte count. The patients were classified two groups as CAD (-) (n=69) and CAD (+) (n=106), then patients in CAD (+) group were divided into 3 groups according to SYNTAX scores (SYNTAX score 1-22, 23-32, >32) as pointed in European Society of Cardiology (ESC) revascularization guideline. Statistical analysis was performed using the Mann-Whitney U and Kruskal-Wallis tests, and multiple logistic regression analysis was used to identify the independent predictors of complexity of CAD-SYNTAX score. Results: Patients with CAD had a significantly higher value of NLR [1.6 median (1.2-3.3 IQR) vs. 2.3 median (1.8-3.0 IQR) p<0.001]. The group with high SYNTAX scores (>32) more frequently had diabetes mellitus (DM), hypercholesterolemia (HL), were of older age, and also had significantly elevated NLR values [2.4 (1.3-2.6), 2.6 (2.3-3.9), 2.0 (1.5-2.6) p=0.006]. In univariate analysis, age, DM, HL, creatinine, neutrophil count and NLR were predictors of high SYNTAX score. In the multiple logistic regression analysis, only NLR [odds ratio (OR)=2.1, 95% confidence interval (CI) 1.2-3.8, p=0.09], was identified as independent predictor of a high SYNTAX score. Conclusion: NLR is a strong clinical laboratory value that is associated with presence and complexity of CAD. (Anadolu Kardiyol Derg 2013; 13: 662-7) Key words: Neutrophil -to-lymphocyte ratio, complexity, coronary artery disease, regression analysis, sensitivity, specificity Original Investigation Özgün Araşt›rma 662ÖZET Amaç: Nötrofil lenfosit oranı (NLO) kardiovasküler risk ve mortalite için yeni bir öngördürücüdür. SYNTAX skoru koroner arter hastalığı (KAH) karmaşıklığını derecelendirmede anjiyografik bir yöntemdir. NLO ile KAH varlığı ve karmaşıklığı arasındaki ilişki henüz ortaya konmamıştır. Biz SYNTAX skorunu kullanarak NLO ile KAH varlığı ve karmaşıklığı arasında daha güçlü bir ilişki olabileceği tezini öne sürdük. Yöntemler: Bu enine kesit gözlemsel çalışmaya 106 koroner anjiyografisi yapılmış stabil angina pectoris hastası ve 69 normal koronere sahip hastalar dahil edildi. Bazal NLO nötrofil sayısının lenfosit sayısına oranı olarak hesaplandı. Hastalar KAH olan ve olmayan şeklinde iki gruba ayrıldı. KAH grubu SYNTAX skoruna göre Avrupa Kardiyoloji Cemiyeti miyokardiyal girişim kılavuzuna dayanarak 3 gruba ayrıldı (23)(24)(25)(26)(27)(28)(29)(30)(31)(32) >32). İstatistiksel analiz Mann-Whitney U ve Kruskal-Wal...

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Section: Discussioncontrasting

confidence: 99%

Section: Original Investigation öZgün Araşt›rma 662unclassified

Relation of neutrophil -to- lymphocyte ratio with the presence and complexity of coronary artery disease: an observational study

Sönmez

Ertaş²,

Bacaksız³

et al. 2013

Anadolu Kardiyol Derg

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“…9 A positive correlation between peripheral PMN count and myocardial infarction has also been reported. 10,11 In patients with chronic stable angina, PMN count and activation are an independent predictor of the presence of multiple complex stenoses irrespective of the extent of coronary artery disease. 7,12 A recent study demonstrated that peripheral blood PMN counts are higher in patients with rheumatoid arthritis implicated with premature atherosclerosis than in control subjects.…”

mentioning

confidence: 99%

Human Neutrophil Peptides Mediate Endothelial-Monocyte Interaction, Foam Cell Formation, and Platelet Activation

Quinn

Henriques

Tabuchi

et al. 2011

ATVB

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“…This colludes with findings that neutrophils can serve as predictors of complex coronary stenosis or myocardial infarction 32 and that the appearance of band neutrophils in peripheral blood ('left shift') correlates with coronary atherosclerosis. 33 Neutrophils endocytose foreign material, produce potent ROS, and release a variety of proteolytic enzymes, such as elastase, and MPO, which help to clear infections but can also participate in tissue degradation and destruction. The levels of MPO and its increased activity in patients with a genetic polymorphism, have been associated with cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

Protective Role of CXC Receptor 4/CXC Ligand 12 Unveils the Importance of Neutrophils in Atherosclerosis

Zernecke

Bot

Djalali-Talab

et al. 2008

Circulation Research

377

315

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Abstract-The CXC ligand (CXCL)12/CXC receptor (CXCR)4 chemokine-receptor axis controls hematopoiesis, organ development, and angiogenesis, but its role in the inflammatory pathogenesis of atherosclerosis is unknown. Here we show that interference with Cxcl12/Cxcr4 by a small-molecule antagonist, genetic Cxcr4 deficiency, or lentiviral transduction with Cxcr4 degrakine in bone marrow chimeras aggravated diet-induced atherosclerosis in apolipoprotein E-deficient (Apoe Ϫ/Ϫ ) or LDL receptor-deficient (Ldlr Ϫ/Ϫ ) mice. Chronic blockade of Cxcr4 caused leukocytosis and an expansion of neutrophils and increased neutrophil content in plaques, associated with apoptosis and a proinflammatory phenotype. Whereas circulating neutrophils were recruited to atherosclerotic lesions, depletion of neutrophils reduced plaque formation and prevented its exacerbation after blocking Cxcr4. Disrupting Cxcl12/Cxcr4 thus promotes lesion formation through deranged neutrophil homeostasis, indicating that Cxcl12/Cxcr4 controls the important contribution of neutrophils to atherogenesis in mice (Circ Res. 2008;102:209-217.)

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Band neutrophil count and the presence and severity of coronary atherosclerosis

Cited by 83 publications

References 21 publications

Relation of neutrophil -to- lymphocyte ratio with the presence and complexity of coronary artery disease: an observational study

Relation of neutrophil -to- lymphocyte ratio with the presence and complexity of coronary artery disease: an observational study

Human Neutrophil Peptides Mediate Endothelial-Monocyte Interaction, Foam Cell Formation, and Platelet Activation

Protective Role of CXC Receptor 4/CXC Ligand 12 Unveils the Importance of Neutrophils in Atherosclerosis

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