Band‐Specific Altered Cortical Connectivity in Early Parkinson's Disease and its Clinical Correlates

Conti, Matteo; Guerra, Andrea; Pierantozzi, Mariangela; Bovenzi, Roberta; D'Onofrio, Valentina; Simonetta, Clara; Cerroni, Rocco; Liguori, Claudio; Placidi, Fabio; Mercuri, Nicola Biagio; Di Giuliano, Francesca; Schirinzi, Tommaso; Stefani, Alessandro

doi:10.1002/mds.29615

Cited by 12 publications

(2 citation statements)

References 91 publications

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“…disease duration; MDS-UPDRS Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale; H&Y Hoehn and Yahr scale; MoCA Montreal Cognitive Assessment; BDI-II Beck Depression Inventory II; LEDD (S1) L-DOPA equivalent daily dose in the first session (L-DOPA); LEDD (S2) L-DOPA equivalent daily dose in the second session (L-DOPA + OPC); SD standard deviation. LEDD are calculated according to previous literature data [ 37 , 38 ]. Clinical scores reflect the values recorded before the L-DOPA intake (T0) in the L-DOPA session (i.e., without Opicapone)…”

Section: Resultsmentioning

confidence: 99%

Objective assessment of the effects of opicapone in Parkinson’s disease through kinematic analysis

Bologna,

Guerra,

Colella

et al. 2023

Neurol Sci

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Background Opicapone (OPC) is a third-generation, selective peripheral COMT inhibitor that improves peripheral L-DOPA bioavailability and reduces OFF time and end-of-dose motor fluctuations in Parkinson’s disease (PD) patients. Objectives In this study, we objectively assessed the effects of adding OPC to L-DOPA on bradykinesia in PD through kinematic analysis of finger movements. Methods We enrolled 20 treated patients with PD and motor fluctuations. Patients underwent two experimental sessions (L-DOPA, L-DOPA + OPC), separated by at least 1 week. In each session, patients were clinically evaluated and underwent kinematic movement analysis of repetitive finger movements at four time points: (i) before their usual morning dose of L-DOPA (T0), (ii) 30 min (T1), (iii) 1 h and 30 min (T2), and (iv) 3 h and 30 min after the L-DOPA intake (T3). Results Movement velocity and amplitude of finger movements were higher in PD patients during the session with OPC compared to the session without OPC at all the time points tested. Importantly, the variability of finger movement velocity and amplitude across T0–T3 was significantly lower in the L-DOPA + OPC than L-DOPA session. Conclusions This study is the first objective assessment of the effects of adding OPC to L-DOPA on bradykinesia in patients with PD and motor fluctuations. OPC, in addition to the standard dopaminergic therapy, leads to significant improvements in bradykinesia during clinically relevant periods associated with peripheral L-DOPA dynamics, i.e., the OFF state in the morning, delayed-ON, and wearing-OFF periods.

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Section: Resultsmentioning

confidence: 99%

Objective assessment of the effects of opicapone in Parkinson’s disease through kinematic analysis

Bologna,

Guerra,

Colella

et al. 2023

Neurol Sci

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“…These tools are designed to inform the development of personalized treatment strategies. The growing interest in “walking,” “balance,” and “nonmotor symptoms ( Conti et al, 2023 )” reflects a broader approach to understanding PD, emphasizing the need to address the multifaceted nature of the disease that affects both motor and cognitive functions ( Bosch et al, 2021 ; Costa et al, 2023 ; Guo et al, 2024 ). As researchers continue to investigate these topics, integrating advanced technologies and holistic approaches promises to drive innovations in the management of PD, potentially leading to earlier detection, more effective treatments, and better patient outcomes.…”

Section: Discussionmentioning

confidence: 99%

Bibliometric analysis of electroencephalogram research in Parkinson’s disease from 2004 to 2023

Liao,

Gao,

Qian

et al. 2024

Front. Neurosci.

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BackgroundParkinson’s disease (PD) is a prevalent neurodegenerative disorder affecting millions globally. It encompasses both motor and non-motor symptoms, with a notable impact on patients’ quality of life. Electroencephalogram (EEG) is a non-invasive tool that is increasingly utilized to investigate neural mechanisms in PD, identify early diagnostic markers, and assess therapeutic responses.MethodsThe data were sourced from the Science Citation Index Expanded within the Web of Science Core Collection database, focusing on publications related to EEG research in PD from 2004 to 2023. A comprehensive bibliometric analysis was conducted using CiteSpace and VOSviewer software. The analysis began with an evaluation of the selected publications, identifying leading countries, institutions, authors, and journals, as well as co-cited references, to summarize the current state of EEG research in PD. Keywords are employed to identify research topics that are currently of interest in this field through the analysis of high-frequency keyword co-occurrence and cluster analysis. Finally, burst keywords were identified to uncover emerging trends and research frontiers in the field, highlighting shifts in interest and identifying future research directions.ResultsA total of 1,559 publications on EEG research in PD were identified. The United States, Germany, and England have made notable contributions to the field. The University of London is the leading institution in terms of publication output, with the University of California closely following. The most prolific authors are Brown P, Fuhr P, and Stam C In terms of total citations and per-article citations, Stam C has the highest number of citations, while Brown P has the highest H-index. In terms of the total number of publications, Clinical Neurophysiology is the leading journal, while Brain is the most highly cited. The most frequently cited articles pertain to software toolboxes for EEG analysis, neural oscillations, and PD pathophysiology. Through analyzing the keywords, four research hotspots were identified: research on the neural oscillations and connectivity, research on the innovations in EEG Analysis, impact of therapies on EEG, and research on cognitive and emotional assessments.ConclusionThis bibliometric analysis demonstrates a growing global interest in EEG research in PD. The investigation of neural oscillations and connectivity remains a primary focus of research. The application of machine learning, deep learning, and task analysis techniques offers promising avenues for future research in EEG and PD, suggesting the potential for advancements in this field. This study offers valuable insights into the major research trends, influential contributors, and evolving themes in this field, providing a roadmap for future exploration.

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Cortical Functional Connectivity Changes in the Body‐First and Brain‐First Subtypes of Parkinson's Disease

Conti,

D'Onofrio,

Bovenzi

et al. 2024

Movement Disorders

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BackgroundRapid eye movement (REM) sleep behavior disorder (RBD) may precede motor symptoms in Parkinson's disease (PD) by years. According to a recent hypothesis, premotor RBD (pRBD) is a marker of the PD body‐first subtype, where synucleinopathy originates from the peripheral autonomic nervous system. Conversely, in the brain‐first subtype, pathology would arise in the brain. Functional connectivity (FC) could provide additional insight into the neurodegenerative process of these putative PD subtypes.ObjectivesWe aim to analyze the possible FC differences between early‐stage PD patients with (PDpRBD+) and without (PDpRBD−) pRBD using high‐density electroencephalography (EEG).MethodsWe enrolled 28 PDpRBD+, 35 PDpRBD−, and 35 healthy controls (HC). Data were recorded with a 64‐channel EEG system, and a source‐reconstruction method was used to identify brain‐region activity. FC was calculated using the weighted phase‐lag index in θ, α, β, and low‐γ bands. Statistical analysis was conducted using network‐based statistic.ResultsWe found a significant trend of decreased α‐FC across PDpRBD+, PDpRBD−, and HC, mainly in prefrontal and temporal areas. The altered α‐FC correlated with Montreal Cognitive Assessment scores in PDpRBD+ and, to a lesser extent, PDpRBD− and with gait/postural disturbances in PDpRBD+ patients only. PDpRBD+ and PDpRBD− had similarly increased FC than HC in a β band network, predominantly involving sensorimotor and limbic areas. The increased β network FC was related to bradykinesia severity in both PD subgroups.ConclusionsCompared to PDpRBD− (brain‐first subtype), PDpRBD+ group (body‐first subtype) demonstrates specific EEG‐FC dysfunctions in the α band, which may reflect early involvement of the cholinergic ascending system. © 2024 International Parkinson and Movement Disorder Society.

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Band‐Specific Altered Cortical Connectivity in Early Parkinson's Disease and its Clinical Correlates

Cited by 12 publications

References 91 publications

Objective assessment of the effects of opicapone in Parkinson’s disease through kinematic analysis

Objective assessment of the effects of opicapone in Parkinson’s disease through kinematic analysis

Bibliometric analysis of electroencephalogram research in Parkinson’s disease from 2004 to 2023

Cortical Functional Connectivity Changes in the Body‐First and Brain‐First Subtypes of Parkinson's Disease

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