Barakol: A potential anxiolytic extracted from Cassia siamea

Thongsaard, Watchareewan; Deachapunya, Chatsri; Pongsakorn, Sakol; Boyd, E.A.; Bennett, Gerald; Ca, Marsden

doi:10.1016/0091-3057(95)02088-8

Cited by 51 publications

(25 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition to endogenous hormones, a number of plant extracts have been shown to have anxiolytic properties [7,52,84,92,115]. Several reports suggest that natural compounds extracted from plants such as Cassia siamea [115], the Eurycoma longifolia Jack root [7], the Azadirachta indica leaf [52] and the Ziziphus jujuba seed [92] have anxiolytic effects.…”

Section: Phytoestrogens and Anxietymentioning

confidence: 99%

“…Several reports suggest that natural compounds extracted from plants such as Cassia siamea [115], the Eurycoma longifolia Jack root [7], the Azadirachta indica leaf [52] and the Ziziphus jujuba seed [92] have anxiolytic effects.…”

Section: Phytoestrogens and Anxietymentioning

confidence: 99%

“…However, when animals are treated with clinically effective anxiolytics, the amount of time spent in the open arms and the number of entries into open arms increase [50,53,84,92]. In addition to synthetic anxiolytic drugs, anxiety, as it is expressed in the plus maze, has also been shown to be affected by steroid hormones [23,31,50,53,75,115] and plant derivatives [7,52,75,114]. Fig.…”

Section: Phytoestrogens and Anxietymentioning

confidence: 99%

See 2 more Smart Citations

Neurobehavioral effects of dietary soy phytoestrogens

Lephart

West

Weber

et al. 2002

Neurotoxicology and Teratology

189

117

View full text Add to dashboard Cite

Section: Phytoestrogens and Anxietymentioning

confidence: 99%

Section: Phytoestrogens and Anxietymentioning

confidence: 99%

Section: Phytoestrogens and Anxietymentioning

confidence: 99%

See 1 more Smart Citation

Neurobehavioral effects of dietary soy phytoestrogens

Lephart

West

Weber

et al. 2002

Neurotoxicology and Teratology

189

117

View full text Add to dashboard Cite

“…The aqueous extract of leaves from the S. siamea species is used in folk medicine to treat insomnia. The anxiolytic activity of the species is attributed to the compound called barakol (Thongsaard et al, 1996). Other species of Cassia spectabilis demonstrated CNS-selective noncompetitive cholinesterase inhibition which was related to the piperidine alkaloid (−)-spectaline isolated from the Cassia spectabilis (Castro et al, 2008).…”

Section: Plants Used In Screening and Their Pharmacological Activitiesmentioning

confidence: 99%

Acetylcholinesterase inhibition by somes promising Brazilian medicinal plants

Feitosa¹,

Freitas²,

Luz³

et al. 2011

Braz. J. Biol.

View full text Add to dashboard Cite

A microplate assay and a thin-layer chromatography (TLC) "in situ" assay based on the Ellman assay was used to screen for acetylcholinesterase inhibitors from ethyl acetate and methanol extracts of Brazilian medicinal plants of families that, according to the literature, have traditional uses that might be connected with acetylcholinesterase inhibition. Eighteen species belonging to Convolvulaceae, Crassulaceae, Euphorbiaceae, Leguminosae, Malvaceae, Moraceae, Nyctaginaceae and Rutaceae families were tested. The most active plants were Ipomoea asarifolia (IC 50 = 0.12 mg/mL), Jatropha curcas (IC 50 = 0.25 mg/mL), Jatropha gossypiifolia (IC 50 = 0.05 mg/mL), Kalanchoe brasiliensis (IC 50 = 0.16 mg/mL) and Senna alata (IC 50 = 0.08 mg/mL). The most promising extracts were the Jatropha gossypiifolia and Senna alata species assuming there were compounds with a similar activity to galanthamine, which should contain about 1% of an active compound, or if present at lower levels even more active compounds than galanthamine (IC 50 = 0.37 x 10 -3 mg/ mL) should be present.Keywords: Brazilian medicinal plants, Alzheimer's disease, acetylcholinesterase inhibitors, microplate assay. Plantas medicinais brasileiras promissoras para inibição da acetilcolinesterase ResumoOs ensaios de microplaca e cromatografia em camada delgada com base no ensaio de Ellman foram usados para triagem de inibidores da acetilcolinesterase dos extratos acetato de etila e metanol de plantas medicinais brasileiras de famílias que, segundo a literatura, tem usos tradicionais que podem estar relacionadas com a inibição da acetilcolinesterase, enzima associada ao mal de Alzheimer. Dezoito plantas das famílias: Convolvulaceae, Crassulaceae, Euphorbiaceae, Leguminosae, Malvaceae, Moraceae, Nyctaginaceae e Rutaceae foram testadas. As espécies mais ativas foram Ipomoea asarifolia (CI 50 = 0,12 mg/mL), Jatropha curcas (CI 50 = 0,25 mg/mL), Jatropha gossypiifolia (CI 50 = 0,05 mg/mL), Kalanchoe brasiliensis (CI 50 = 0,16 mg/mL) e Senna alata (CI 50 = 0,08 mg/mL). Os extratos mais promissores foram os das espécies Jatropha gossypiifolia e Senna alata, assumindo a presença de compostos com atividade semelhante à galantamina que deve conter cerca de 1% de um composto ativo, ou se presentes em menores níveis ainda mais compostos ativos que a galantamina (CI 50 = 0,37 x10 -3 mg/mL) devem estar presentes.Palavras-chave: plantas medicinais brasileiras, doença de Alzheimer, inibidores da acetilcolinesterase, microplaca.

show abstract

“…1), and a proposed synthetic procedure was described in 1970 (Bycroft et al, 1970). In animal model studies, barakol has been shown to possess hypotensive activity (Suwan et al, 1992) and serotonergic receptor antagonist activity (Tongroach et al, 1992), and it appears to function as an anxiolytic in exploratory behavioral activities (Thongsaard et al, 1996). Further in vitro studies in the central nervous system have found that barakol inhibits K ϩ -stimulated dopamine release from striatal slices of rat brain (Thongsaard et al, 1997).…”

mentioning

confidence: 99%

Barakol Extracted from Cassia siamea Stimulates Chloride Secretion in Rat Colon

Deachapunya

Poonyachoti²,

Thongsaard³

et al. 2005

J Pharmacol Exp Ther

View full text Add to dashboard Cite

Barakol is a purified extract of Cassia siamea, a plant that has been used as a laxative in traditional medicine. In this study, the effect of barakol on anion transport across the rat colon epithelium was investigated. Colonic epithelium was mounted in Ussing chambers and bathed with Ringer's solution. Addition of 1 mM barakol to the basolateral solution produced a slow increase in short-circuit current (Isc) in proximal colon and distal colon by 24.5 Ϯ 2.2 and 24.2 Ϯ 1.4 A/cm 2 , respectively. Barakol increased Isc in a concentration-dependent manner with an EC 50 value of 0.4 mM. The barakol-stimulated increase in Isc was inhibited by subsequent treatment with 500 M diphenylamine-2-carboxylic acid or 400 M glibenclamide added to the apical solution and 200 M bumetanide added to the basolateral solution. Pretreatment of the tissues with 200 M bumetanide, but not 10 M amiloride, completely abolished the barakol-increased Isc. Ion substitution experiments showed an inhibition of barakol-stimulated Isc in chloride-free solution but not in bicarbonate-free solution. In addition, pretreatment of tissues with 10 M tetrodotoxin or 10 M indomethacin, but not 1 M atropine or 10 M hexamethonium, partially inhibited the Isc response by barakol. The present results demonstrated the stimulatory effect of barakol on the bumetanide-sensitive chloride secretion in rat colon. The effect of barakol was partly mediated by the stimulation of submucosal nerves and through the release of cyclooxygenase metabolites. These findings thus provide an explanation for the underlying mechanism of barakol as a secretagogue in mammalian colon.

show abstract

Barakol: A potential anxiolytic extracted from Cassia siamea

Cited by 51 publications

References 10 publications

Neurobehavioral effects of dietary soy phytoestrogens

Neurobehavioral effects of dietary soy phytoestrogens

Acetylcholinesterase inhibition by somes promising Brazilian medicinal plants

Barakol Extracted from Cassia siamea Stimulates Chloride Secretion in Rat Colon

Contact Info

Product

Resources

About