Sedation and Analgesia for the Pediatric Intensivist 2020
DOI: 10.1007/978-3-030-52555-2_7
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Barbiturates in the Pediatric ICU

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Cited by 1 publication
(6 citation statements)
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“…Barbiturates are useful for their antiepileptic properties and their ability to control intracranial hypertension. Similar to benzodiazepines, barbiturates act primarily via GABA agonism [ 144 , 145 ]. Respiratory depression and hypotension can occur with barbiturates and caution should be taken when weaning from prolonged infusions in order to avoid withdrawal.…”
Section: Sedationmentioning
confidence: 99%
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“…Barbiturates are useful for their antiepileptic properties and their ability to control intracranial hypertension. Similar to benzodiazepines, barbiturates act primarily via GABA agonism [ 144 , 145 ]. Respiratory depression and hypotension can occur with barbiturates and caution should be taken when weaning from prolonged infusions in order to avoid withdrawal.…”
Section: Sedationmentioning
confidence: 99%
“…Its peak onset is 1–2 min and the duration of action is 30 min [ 146 ]. The dose is age-dependent with infants requiring much higher induction doses of 5–8 mg/kg compared to children, teens and adults at 3–4 mg/kg [ 144 , 147 , 148 ]. Thiopental is metabolized by hydroxylation and oxidation via hepatic metabolism and it has a long elimination half-life of up to 12 h [ 144 , 149 ].…”
Section: Sedationmentioning
confidence: 99%
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