Bariatric surgery: beta cells in type 2 diabetes remission

Abstract

Bariatric surgery is a new emerging treatment that demonstrates a favourable effect on type 2 diabetes, although its underlying mechanisms still remain unknown. After receiving bariatric surgery, beta cells undergo the process of rebirth, which involves apoptosis evasion, regeneration and improved beta-cell function. Therefore, further studies are necessary to elucidate how bariatric surgery can resolve type 2 diabetes. Here, our review focuses mainly on beta cells, the insulin-generating cells, whose biological features change dramatically after bariatric surgery. Copyright © 2015 John Wiley & Sons, Ltd.

Association of circulating proinflammatory marker, leucine‐rich‐α2‐glycoprotein (LRG1), following metabolic/bariatric surgery

“…In addition to weight improvements, both short‐term and long‐term diabetes remission have been shown to occur after bariatric surgery in 60% to 90% of patients. Success in diabetes remission has been attributed to both weight‐dependent and weight‐independent mechanisms, including gut hormone metabolism, improved beta cell function, and reduced inflammation . Although the inflammatory marker, HsCRP, is an independent determinant of baseline plasma LRG1, levels did not change significantly after surgery.…”