Barthel Index-based functional status as a prognostic factor in young and middle-aged adults with newly diagnosed gastric, colorectal and lung cancer: a multicentre retrospective cohort study

Morishima, Toshitaka; Sato, Akira; Nakata, Kayo; Matsumoto, Yoshihisa; Koeda, Nobuyuki; Shimada, Hiroko; Maruhama, Tsutomu; Matsuki, Daisaku; Miyashiro, Isao

doi:10.1136/bmjopen-2020-046681

Cited by 19 publications

(21 citation statements)

References 33 publications

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“…In this study, ADL was evaluated using the Barthel index. The Barthel index evaluates not only stroke and orthopedic disorders but also the functional status and ADL of cancer patients [ 19 , 20 ]. In our study, ADL before RT affected the survival rate of patients with spinal bone metastases.…”

Section: Discussionmentioning

confidence: 99%

Association between Overall Survival and Activities of Daily Living in Patients with Spinal Bone Metastases

et al. 2022

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Objective: This study aimed to investigate the association between overall survival (OS) and activities of daily living (ADL) in patients with skeletal-related events. In this study, 265 patients whose clinical parameters were available before radiotherapy were investigated. Methods: Age, sex, ADL, pain, the primary site, spinal level of bone metastases, spinal instability, treatment strategy, including chemotherapy or palliative treatment, and OS were investigated. ADL patients with a Barthel index of ≥ 90 were classified as the high ADL group, while those with a score < 90 were classified as the low ADL group. For OS, patients surviving ≥ 160 days were classified as the non-poor prognosis group, and those who survived < 160 days were classified as the poor prognosis group. Results: Age, sex, ADL, pain, the primary site, and treatment strategy for OS were different between the two groups (p < 0.1). Logistic regression analysis revealed that ADL, the primary site, and treatment strategy were significant predictors of OS (p < 0.05). High ADL, breast cancer, and chemotherapy had a positive effect on OS. Conclusions: It is suggested that improvements may be obtained by performing rehabilitation interventions to maintain and improve ADL, by constructing a system for monitoring spinal bone metastases with images before ADL decreases, and by performing interventions such as changes in treatment methods such as RT or surgery at appropriate times.

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Section: Discussionmentioning

confidence: 99%

Association between Overall Survival and Activities of Daily Living in Patients with Spinal Bone Metastases

et al. 2022

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“…The study database was produced through the linkage of hospital-based cancer registry data, prefectural cancer registry data, and administrative data. The data were obtained with support from the Council for Coordination of Designated Cancer Care Hospitals in Osaka 15 – 20 .…”

Section: Methodsmentioning

confidence: 99%

“…Higher CCI scores indicate a higher risk of death. The Barthel index was used to measure performance in ADL because of its association with cancer survival 15 , 16 . This index uses a scale of 0–100 with higher scores indicating better functional status, and patients were grouped into four categories: no disability (score: 100), moderate disability (60–95), severe disability (0–55), and unknown 15 .…”

Section: Methodsmentioning

confidence: 99%

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Between-hospital variations in 3-year survival among patients with newly diagnosed gastric, colorectal, and lung cancer

Morishima

Okawa

Koyama

et al. 2022

Sci Rep

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Due to increases in cancer survivability, quality assessments of cancer care must include long-term outcomes. This multicenter retrospective cohort study evaluated between-hospital variations in the 3-year survival rates of patients with gastric, colorectal, and lung cancer irrespective of treatment modality. We linked cancer registry data and administrative data from patients aged 18–99 years who were diagnosed with gastric, colorectal, or lung cancer between 2013 and 2015 in Osaka Prefecture, Japan. The 3-year survival rates were adjusted for potential prognostic factors using multilevel logistic regression models. Between-hospital variations were visually evaluated using funnel plots. We analyzed 10,296 gastric cancer patients from 30 hospitals, 9276 colorectal cancer patients from 30 hospitals, and 7978 lung cancer patients from 28 hospitals. The 3-year survival rate was 70.2%, 75.2%, and 45.0% for gastric, colorectal, and lung cancer, respectively. In the funnel plots, the adjusted survival rates of gastric and colorectal cancer for all hospitals lay between the lower and upper control limits of two standard deviations of the average survival rates. However, the adjusted survival rates of lung cancer for four hospitals lay below the lower limit while that for two hospitals lay above the upper limit. Older age, men, advanced cancer stage, comorbidities, functional disability, emergency admission, current/ex-smokers, and underweight were independently associated with poorer survival. In conclusion, there were between-hospital variations in 3-year survival for lung cancer even after adjusting for case mix. Quality improvement initiatives may be needed to raise the consistency of care.

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“…A pre-existing functional disability at the time of diagnosis seems to have a significantly lower survival rate and indicates a need for interventions to improve prognosis ( 21 ).…”

Section: Patient Selectionmentioning

confidence: 99%

Current Surgical Therapy of Locally Advanced cSCC: From Patient Selection to Microsurgical Tissue Transplant. Review

et al. 2021

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Among the non-melanoma skin cancers (NMSC) the squamous cell carcinoma (SCC) is one of the most challenging for the surgeon. Local aggressiveness and a tendency to metastasize to regional lymph nodes characterize the biologic behavior. The variants locally advanced and metastatic require wide excision and node dissection. Such procedures can be extremely detrimental for patients. The limit of the surgery can be safely pushed forward with a multidisciplinary approach. The concept of skin oncoplastic surgery, the ablative procedures and the reconstructive options (skin graft, pedicled flap, microsurgical free flap) are discussed together with a literature review.

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Barthel Index-based functional status as a prognostic factor in young and middle-aged adults with newly diagnosed gastric, colorectal and lung cancer: a multicentre retrospective cohort study

Cited by 19 publications

References 33 publications

Association between Overall Survival and Activities of Daily Living in Patients with Spinal Bone Metastases

Association between Overall Survival and Activities of Daily Living in Patients with Spinal Bone Metastases

Between-hospital variations in 3-year survival among patients with newly diagnosed gastric, colorectal, and lung cancer

Current Surgical Therapy of Locally Advanced cSCC: From Patient Selection to Microsurgical Tissue Transplant. Review

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