Bartonella alsatica endocarditis in a French patient in close contact with rabbits

Jeanclaude, D.; Godmer, P.; Leveiller, D.; Pouëdras, P.; Fournier, Pierre‐Edouard; Raoult, Didier; Rolain, Jean‐Marc

doi:10.1111/j.1469-0691.2008.02187.x

Cited by 35 publications

(25 citation statements)

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“…During the study period, we diagnosed 106 cases of Bartonella endocarditis, 47 of which have been mentioned or reported (11,(13)(14)(15)19). Serum, EDTA blood, and valvular specimens were available for 102, 60, and 52 of these patients, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…berkhoffii (9,10), B. vinsonii subsp. arupensis (11), Bartonella koehlerae (12), Bartonella alsatica (13,14), and "Candidatus Bartonella mayotimonensis" (15), have occasionally been reported in the literature. Epidemiological data suggest a European-African gradient distribution in the prevalence of Bartonella endocarditis, the highest prevalence being reported in southern countries (7).…”

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confidence: 99%

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Bartonella, a Common Cause of Endocarditis: a Report on 106 Cases and Review

et al. 2015

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Bartonella spp. are fastidious bacteria that cause blood culture-negative endocarditis and have been increasingly reported. In this study, we included all patients retrospectively and prospectively diagnosed with Bartonella endocarditis in our French reference center between 2005 and 2013. Our diagnosis was based on the modified Duke criteria and microbiological findings, including serological and PCR results. To review the published literature, we searched all human Bartonella endocarditis cases published in the PubMed database between January 2005 and October 2013. We report here a large series of 106 cases, which include 59 cases that had not previously been reported or mentioned. Indirect immunofluorescence assays, Western blotting, and realtime PCR from total blood, serum, and valve tissue exhibited sensitivities of 58%, 100%, 33%, 36%, and 91%, respectively. The number of cases reported in the literature between 2005 and 2013 increased to reach a cumulative number of 196 cases. The number of cases reported in the literature by other centers is increasing more rapidly than that reported by our French reference center (P < 10 ؊2 ). Currently, there is a lack of criteria for the diagnosis of Bartonella endocarditis. We suggest that a positive PCR result from a cardiac valve or blood specimen, an IgG titer of >800 using an immunofluorescence assay, or a positive Western blot assay be considered major Duke criteria for Bartonella endocarditis. There is no real increase in the incidence of these infections but rather a better understanding and interest in the disease resulting from the improvement of diagnostic tools.

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

Bartonella, a Common Cause of Endocarditis: a Report on 106 Cases and Review

et al. 2015

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“…Close contact with rabbit has been signaled as a main epidemiological factor of transmission of B. alsatica to humans ( Jeanclaude et al 2009). As Oryctolagus cuniculus is a very important game species in Spain and Portugal (Virgó s et al 2007), hunters' contact with infected animals can be extremely common, and so the possibility of infection with this Bartonella should be extremely high.…”

Section: Discussionmentioning

confidence: 98%

“…Analyzing heart valve tissue biopsies in patients with endocarditis (Raoult et al 2006, Jeanclaude et al 2009) would be, together with continuing entomological surveys, the best way to increase our knowledge of emerging fleaborne bartonellosis in Spain and more generally in the West Mediterranean basin.…”

Section: Discussionmentioning

confidence: 99%

“…Bartonella alsatica is a human pathogen that was formerly isolated from the blood of European rabbit in Alsace Department, France (Heller et al 1999), and identified as a causative agent of endocarditis and lymphadenitis in humans (Raoult et al 2006, Angelakis et al 2008, Jeanclaude et al 2009). European rabbit (Oryctolagus cuniculus) has been indicated as the natural host of this Bartonella species, but the vector has not yet been determined (Vayssier-Taussat et al 2009).…”

Section: Introductionmentioning

confidence: 99%

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Molecular Detection of Bartonella alsatica in European Wild Rabbits (Oryctolagus cuniculus) in Andalusia (Spain)

Márquez

2010

Vector-Borne and Zoonotic Diseases

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A sample of 279 European wild rabbits, Oryctolagus cuniculus (141 males, 138 females), captured alive in Andalusia (Spain) and belonging to the two haplotype classes previously described for this species (230 and 49 corresponding with haplotypes A and B, respectively), were tested for the presence of Bartonella alsatica DNA. Two species-specific nested polymerase chain reaction assays targeting for 16S-23S rRNA intergenic spacer region and RNA polymerase β subunit genes have been developed. Forty-eight (17.20%) rabbits were infected with B. alsatica. Two-way contingency table analyses and the calculation of Cramer's V statistic showed no differences in infection rate, considering haplotype lineage or sex. The risk of infection of human population, especially for hunters in close contact with this demonstrated human pathogen, should be considered.

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Arthropods

Monsel

Delaunay

Chosidow

2016

Rook's Textbook of Dermatology, Ninth Edition

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Many arthropod species are capable of inflicting bites and stings on humans. They produce their effects on the skin by a variety of mechanisms, resulting in a wide spectrum of clinical lesions. Reaction to arthropod assaults can range from mild to life threatening. Diagnosis of arthropod bites is often self‐evident, but may be difficult when the source of the bites is not immediately obvious. An entomologist is often invaluable in these situations. Many diseases have arthropods vectors, for example malaria (mosquitoes), leishmaniasis (sandflies) and typhus (lice). The terrestrial arthropods of medical interest include the orders Insecta (insects), Arachnida (arachnida), Chilopoda (centipedes) and Diplopoda (millipedes).

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Bartonella alsatica endocarditis in a French patient in close contact with rabbits

Cited by 35 publications

References 5 publications

Bartonella, a Common Cause of Endocarditis: a Report on 106 Cases and Review

Bartonella, a Common Cause of Endocarditis: a Report on 106 Cases and Review

Molecular Detection of Bartonella alsatica in European Wild Rabbits (Oryctolagus cuniculus) in Andalusia (Spain)

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