Basal and exercise‐induced sympathetic nervous activity and lipolysis in adipose tissue of patients with anorexia nervosa

Barták, V; Vybíral, S; Papežová, Hana; Dostálová, I; Pacák, Karel; Nedvı́dková, J

doi:10.1111/j.1365-2362.2004.01344.x

Cited by 33 publications

(31 citation statements)

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“…In the current study there was no effect of isolation/restraint stress on DOPA and this is similar to our previous findings in sheep [40]. Similarly, there was no effect of exercise stress in humans [83] or novel stress in rats [84] on plasma concentrations of DOPA although mental stress caused an increase in plasma DOPA in humans [85]. In contrast, the plasma concentrations of DHPG increased during isolation/restraint in both lean and fat ewes and a similar increase in plasma DHPG was also found in rats due to novel stress [84].…”

Section: Discussionsupporting

confidence: 81%

Responses of the Hypothalamopituitary Adrenal Axis and the Sympathoadrenal System to Isolation/Restraint Stress in Sheep of Different Adiposity

et al. 2008

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There is evidence that levels of adipose tissue can influence responses of the hypothalamopituitary-adrenal (HPA) axis to stress in humans and rats but this has not been explored in sheep. Also, little is known about the sympathoadrenal responses to stress in individuals with relatively different levels of adipose tissue. We tested the hypothesis that the stress-induced activation of the HPA axis and sympathoadrenal system is lower in ovariectomized ewes with low levels of body fat (lean) than ovariectomized ewes with high levels of body fat (fat). Ewes underwent dietary manipulation for 3 months to yield a group of lean ewes (n = 7) with a mean (±SEM) live weight of 39.1 ± 0.9 kg and body fat of 8.9 ± 0.6% and fat ewes (n = 7) with a mean (±SEM) live weight of 69.0 ± 1.8 kg and body fat of 31.7 ± 3.4%. Fat ewes also had higher circulating concentrations of leptin than lean ewes. Blood samples were collected every 15 min over 8 h when no stress was imposed (control day) and on a separate day when 4 h of isolation/restraint was imposed after 4 h of pretreatment sampling (stress day). Plasma concentrations of adrenocorticotropic hormone (ACTH), cortisol, epinephrine and norepinephrine did not change significantly over the control day and did not differ between lean and fat ewes. Stress did not affect plasma leptin levels. All stress hormones increased significantly during isolation/restraint stress. The ACTH, cortisol and epinephrine responses were greater in fat ewes than lean ewes but norepinephrine responses were similar. Our results suggest that relative levels of adipose tissue influence the stress-induced activity of the hypothalamopituitary-adrenal axis and some aspects of the sympathoadrenal system with fat animals having higher responses than lean animals.

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Section: Discussionsupporting

confidence: 81%

Responses of the Hypothalamopituitary Adrenal Axis and the Sympathoadrenal System to Isolation/Restraint Stress in Sheep of Different Adiposity

et al. 2008

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“…Exercise has been shown to alter concentrations of certain hormones and neurotransmitters that may influence leptin concentrations [14,18,19,39]. Among these, catecholamines have been shown to inhibit leptin production as well as plasma leptin levels [40,41], whereas insulin has been shown to stimulate leptin [24].…”

Section: Discussionmentioning

confidence: 98%

“…Exercise alters concentrations of certain hormones that may alter leptin concentrations, including insulin, cortisol, catecholamines, and growth hormone [17][18][19]. Among these, lipolytic norepinephrine (NE) and antilipolytic insulin play an important counteracting role in the regulation of leptin production.…”

Section: Introductionmentioning

confidence: 99%

“…We hypothesized that in underweight patients with AN who have markedly low plasma leptin [29] and insulin levels (Dostalova et al, 2006, in press) and increased exercise-induced adipose tissue NE and glycerol levels [19], the production of leptin during a single bout of lowintensity exercise could be altered and could contribute to extreme sensitivity of these patients to energy imbalance and consequently to weight loss (ie, relapse). Therefore, we decided to investigate the effect of a single bout of exercise on plasma leptin, NE, insulin, and glycerol levels in patients with AN.…”

Section: Introductionmentioning

confidence: 99%

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The effect of short-term exercise on plasma leptin levels in patients with anorexia nervosa

Dostálová¹,

Barták²,

Papežová³

et al. 2007

Metabolism

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“…A AN está associada com alterações graves de metabolismo lipídico e de carboidratos, incluindo o aumento da lipólise no tecido adiposo (BARTÁK et al 2004;KŘÍŽOVÁ et al 2008;NEDVÍDKOVÁ et al 2004 …”

Section: Spssunclassified

Indicadores clínicos e bioquímicos de risco cardiovascular em adultos com transtornos alimentares

Teraoka¹

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2 ; 86,4% apresentaram valores de CA normais; 95% com ITB normal, 70% com delta ITB (diferença entre os ITBs) normal; 95,4% com cifras de PA inferiores a 120x80 mmHg, 18,2% com pulso radial inferior a 60 batimentos por minuto; 9,1% com pressão de pulso >50 mmHg. A soma das quatro dobras cutâneas foi de 62,05 ± 19,92 mm, e o percentual de gordura foi de 28,95 ± 5,65; 47,6% classificaram-se como acima da média para o risco de morbidade, devido à alta porcentagem de gordura corporal, de acordo com as dobras cutâneas. Quanto aos exames bioquímicos, 42,1% apresentaram aumento nos níveis do colesterol total; 33,3%, aumento do LDL-C, 10,5%, aumento nos níveis de triglicérides, 18,2%, aumento da homocisteína, 31,8%, aumento do ácido fólico, 4,5%, da PCR e 9,0% estavam com níveis de vitamina B 12 maiores ou menores do que os valores de referência. Houve associação estatisticamente significante para a associação entre o IMC e o diagnóstico de AN e bulimia nervosa, p=0,002. Concluímos que as pessoas com TA apresentaram indicadores clínicos e bioquímicos de risco cardiovascular, devendo ser adotadas medidas e ações preventivas que priorizem a promoção da saúde neste grupo de indivíduos. This is a cross-sectional descriptive study with quantitative approach that aim to find out the clinical and biochemical indicators of cardiovascular risk among people diagnosed with eating disorders (ED). The population was composed of 22 users an outpatient follow-up from two university hospitals located on the countryside and capital of São Paulo during the period from March 2013 to February 2014. The data collection occurred through interview to identify socio-demographic variables such as age, sex, skin color, marital status, education, and family income. The clinical data collected from anthropometric assessment were height, weight, waist circumference (WC), and body mass index (BMI); skinfold-thickness measurement: triceps, biceps, subscapular and suprailiac; indirect measurement of blood pressure (BP) and ankle-brachial index (ABI); body fat percentage. Laboratory examinations were carried out to identify the presence of C-reactive protein (CRP), cholesterol (total or individual components), triglycerides, homocysteine, vitamin B 12 , and folic acid. The data were grouped into categories and the quantitative variables were expressed as median and standard deviation. It was used SPSS (Statistical Package for the Social Science), version 16.0 and R i386 version 3.0.0 and the significance level adopted was α=0.05. It was used the Fisher Exact Test for association analysis between BMI classification (eutrophic and low weight) with clinical, anthropometric and biochemical variables. The average age of participants was 28.41 ± 7.51 years, female (95.5%), white (86.4%), not living with a partner (72.7%), students (45.5%), employment relationship (31.9%), bachelor degree in progress or incomplete (31.8%) with average study of 12.45 ± 2.94 years, and family income between three and four minimum wages (59.1%); the medical diagnosis presented t...

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Basal and exercise‐induced sympathetic nervous activity and lipolysis in adipose tissue of patients with anorexia nervosa

Abstract: Our study provides evidence of elevated baseline and exercise-induced sympathetic nervous activity and exercise-induced lipolysis in abdominal AT of AN patients.

Cited by 33 publications

References 25 publications

Responses of the Hypothalamopituitary Adrenal Axis and the Sympathoadrenal System to Isolation/Restraint Stress in Sheep of Different Adiposity

Responses of the Hypothalamopituitary Adrenal Axis and the Sympathoadrenal System to Isolation/Restraint Stress in Sheep of Different Adiposity

The effect of short-term exercise on plasma leptin levels in patients with anorexia nervosa

Indicadores clínicos e bioquímicos de risco cardiovascular em adultos com transtornos alimentares

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