Basal cell carcinoma with intravascular invasion

Abstract

We report the case of a 59-year-old Caucasian male with a primary in ltrative BCC with vascular invasion on the right temple. An excision biopsy was taken and histology con rmed BCC, 2.5mm thick, invading into the reticular dermis. The patient underwent a scar excision which demonstrated no further malignancy. The patient showed no clinical signs of recurrence 2 years a er diagnosis. Relevance:Basal cell carcinoma (BCC) is the most common human malignancy and its incidence is increasing. Less than 1% of BCCs metastasize and very few cases of intravascular invasion by a primary BCC have been reported. This report discusses the clinical features of a BCC, the population at risk and summarises all known cases of BCC with vascular invasion in the literature. Take Home Messages:Due to the rarity of basal cell carcinoma with vascular invasion, there is a poor understanding of the disease process and the metastatic potential, resulting in uncertainty for clinician and patient regarding appropriate management.The British Student Doctor, 2020;4(1):41-44

Significance of Basal Cell Carcinomas Exhibiting Intravascular Invasion

“…Some cases confirmed IVBCC with special stains and IHC to highlight vascular tissue, identify BCC, or rule out other confounding entities such as Merkel cell carcinoma. 7,9–11,15,23–25…”

“…Some cases confirmed IVBCC with special stains and IHC to highlight vascular tissue, identify BCC, or rule out other confounding entities such as Merkel cell carcinoma. 7,[9][10][11]15,[23][24][25] By adapting the criteria used by Mete and Asa, 19 perhaps similar criteria to stringently define IVBCC can help gather cases for further study and clarify clinical significance. A set of proposed criteria for IVBCC could include the following:…”

The risk and strain of working during the COVID‐19 pandemic

“…Migrant workers have notoriously been subject to stigma by host communities, but the pandemic and fears that migrants were carriers of the disease heightened xenophobic sentiments, as well as making the return to their place of origin more difficult. 78 Accounts of stigma were also common among health professionals, as members of the public believed they would be likely to spread the virus because of their close contacts with those infected. A July 2020 article in The Lancet recounted cases of healthcare workers being denied access to public transportation as well as physical assault.…”

Intravascular Basal Cell Carcinoma: Report of a Case and Literature Review

“…Although perineural invasion (PNI) has been extensively documented, only a few cases featuring intravascular invasion have been reported, with its clinical significance yet to be determined. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] We present the case of an 85-yearold White woman with no history of cutaneous malignancy. She presented with an erythematous lesion of unknown duration on the nasal dorsum.…”

“…Although perineural invasion (PNI) has been extensively documented, only a few cases featuring intravascular invasion have been reported, with its clinical significance yet to be determined. 1–15…”