Basal cell carcinomas in elderly patients treated by cryotherapy

Chiriac, Anca; Mihăilă, Doina; Foia, Liliana; Solovan, Caius

doi:10.2147/cia.s42174

Cited by 7 publications

(5 citation statements)

References 5 publications

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“…Clinical implications of cryosurgery are mostly applied in BCC [32]. However, they hold limitations such as loss of pigmentation, loss of sensation, scarring loss of hair, and nerve damage in regions at the surgical site [33]. Among the available therapeutic modalities, radiation therapy is considered one of the best treatment options for skin cancer which controls the rate of tumor growth in about 87%-100% of cases for 2-5 years.…”

Section: Current Treatment and Their Limitationsmentioning

confidence: 99%

Nano-based formulations of curcumin: elucidating the potential benefits and future prospects in skin cancer

Ratan,

Arian,

Rajendran

et al. 2023

Biomed. Mater.

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Skin cancer refers to any malignant lesions that occur in the skin and are observed predominantly in populations of European descent. Conventional treatment modalities such as excision biopsy, chemotherapy, radiotherapy, immunotherapy, electrodesiccation, and photodynamic therapy induce several unintended side effects which affect a patient’s quality of life (QOL) and physical well-being. Therefore, spice-derived nutraceuticals like curcumin, which are well tolerated, less expensive, and relatively safe, have been considered a promising agent for skin cancer treatment. Curcumin, a chemical constituent extracted from the Indian spice, turmeric, and its analogues has been used in various mammalian cancers including skin cancer. Curcumin has anti-neoplastic activity by triggering the process of apoptosis and preventing the multiplication and infiltration of the cancer cells by inhibiting some signalling pathways and thus subsequently preventing the process of carcinogenesis. Curcumin is also a photosensitizer and has been used in PDT. The major limitations associated with curcumin are poor bioavailability, instability, limited permeation into the skin, and lack of solubility in water. This will constrain the use of curcumin in clinical settings. Hence, developing a proper formulation that can ideally release curcumin to its targeted site is important. So, several nanoformulations based on curcumin have been established such as nanogels, nanoemulsions, nanofibers, nanopatterned films, nanoliposomes and nanoniosomes, nanodisks, and cyclodextrins. The present review mainly focuses on curcumin and its analogues as therapeutic agents for treating different types of skin cancers. The significance of using various nanoformulations as well non-nanoformulations loaded with curcumin as an effective treatment modality for skin cancer is also emphasized.

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Section: Current Treatment and Their Limitationsmentioning

confidence: 99%

Nano-based formulations of curcumin: elucidating the potential benefits and future prospects in skin cancer

Ratan,

Arian,

Rajendran

et al. 2023

Biomed. Mater.

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“…The cryosurgical method (also known as cryotherapy or cryoablation) has a number of unique properties and advantages [16,17], leading to its' wide use for treatment of premalignant skin lesions [18,19], skin cancers [20][21][22], as well as malignant tumors of other locations [23][24][25]. Cryoablation is a well-established routine therapeutic modality in current oncological practice in our country and abroad.…”

Section: Introductionmentioning

confidence: 99%

Cryosurgery for Basal Cell Skin Cancer of the Head: 15 Years of Experience

Pustinsky,

Dvornikov,

Kiva

et al. 2023

Life

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The clinical relevance of head and neck (H&N) tumors is related to the potential disfiguration of anatomical structures (by the tumor or surgical intervention), defining patients’ individual features and emotional expression, loss or restraint of vital structures functions, and untoward socio-economic sequelae. This study is aimed to improve clinical outcomes of cryosurgery in patients with H&N basal cell skin cancer by refining the indications for cryosurgical treatment. In this study, cryosurgery was used in 234 patients with different stages of cutaneous basal cell carcinoma (BCC) of the head, including 101 patients with T1 tumors, 86—with T2, 5—T3, and 42 patients with tumors relapsing after failure of preceding various treatment modalities. Post-cryosurgery recurrence rate in patients with stage I BCC was 2.7%, with stage II tumors—5.6% and 34.9%—in patients with recurred tumors. Re-recurrence after cryoablation of recurrent tumors correlated with the tumor baseline size. The best aesthetic and long-term clinical results were documented in patients with lesions <1 cm in size with clear boundaries. Thus, cryosurgery is the method of choice for the majority of stage I basal cell carcinomas of the head. For patients with advanced and recurrent skin cancer, cryosurgery is relevant in rare cases selected according to refined indications.

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“… 5 Cryotherapy is minimally-invasive, easy to perform, inexpensive, elicits minimal pain, can reach tumors in difficult locations, and can also be performed in elderly patients. 6 …”

Section: Introductionmentioning

confidence: 99%

“…5 Cryotherapy is minimally-invasive, easy to perform, inexpensive, elicits minimal pain, can reach tumors in difficult locations, and can also be performed in elderly patients. 6 Based on outpatient medical records data from the Department of Dermatovenereology of Hasan Sadikin Hospital, Bandung, Indonesia, from January 1, 2015, to December 31, 2020, there were 55 BCC cases, with 13 of them having nodular subtype. This case report aims to report a case of nodular BCC treated with cryotherapy.…”

Section: Introductionmentioning

confidence: 99%

Cryotherapy as an Effective therapeutic Option in Patients with Nodular Basal Cell Carcinoma - Case Report

Sutedja¹,

Satjamanggala²,

Sutedja³

et al. 2022

IMCRJ

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Basal cell carcinoma (BCC) is a malignant tumor originating from epidermal cells. A case of BCC was reported in a 67-year-old female, with the initial complaint of skin-colored papules, which later turned into a nodule with erosion and crusts on the right shoulder. The diagnosis is established from findings consistent with nodular BCC on physical examination, and from dermoscopic appearance revealing ulceration, blue-gray ovoid nests, deeply pigmented border, and arborizing vessels. Histopathological examination showed tumor cells forming palisading structures with myxoid stroma, polymorphic, hyperchromatic and mitotic nuclei, as well as fibrocollagen connective tissue cells with lymphocyte infiltrates. Cryotherapy is a therapeutic option for BCC in old patients and has a cure rate of around 95%. Observation on the 25th day revealed clinical improvement with reduced nodular lesion size; thus, further cryotherapy was needed to enhance the therapeutic outcomes.

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Basal cell carcinomas in elderly patients treated by cryotherapy

Cited by 7 publications

References 5 publications

Nano-based formulations of curcumin: elucidating the potential benefits and future prospects in skin cancer

Nano-based formulations of curcumin: elucidating the potential benefits and future prospects in skin cancer

Cryosurgery for Basal Cell Skin Cancer of the Head: 15 Years of Experience

Cryotherapy as an Effective therapeutic Option in Patients with Nodular Basal Cell Carcinoma - Case Report

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