Basal insulin ameliorates post-breakfast hyperglycemia via suppression of post-breakfast proinsulin/C-peptide ratio and fasting serum free fatty acid levels in patients with type 2 diabetes

Ogiso, Kazuma; Koriyama, Nobuyuki; Obo, Takahiko; Tokito, Akinori; Nishio, Yoshihiko

doi:10.1007/s13340-020-00457-3

Cited by 1 publication

(1 citation statement)

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“…However, the insulin-to-carbohydrate ratio and ISF should be revised when the blood glucose variation (hypo/hyperglycemia) occurs within four hours of the bolus or meal or after giving a correction insulin bolus. To test the basal rate, we should eliminate the influence of other factors that could affect it by dividing the day into windows, testing the basal rate for each window on different days, and ensuring that the tested person follows his/her usual routine without strenuous activity before the test by 24 h and during the test period[ 49 , 50 ]. Hypoglycemia should not present during the last 12 h before testing, and the patients should be fasting for the tested period except for water.…”

Section: Use Of the Insulin Pumpmentioning

confidence: 99%

Insulin pumps in children - a systematic review

Al‐Biltagi¹,

Saeed²,

Bediwy³

et al. 2022

World J Clin Pediatr

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BACKGROUND Insulin pump therapy is a real breakthrough in managing diabetes Mellitus, particularly in children. It can deliver a tiny amount of insulin and decreases the need for frequent needle injections. It also helps to maintain adequate and optimal glycemic control to reduce the risk of metabolic derangements in different tissues. Children are suitable candidates for pump therapy as they need a more freestyle and proper metabolic control to ensure adequate growth and development. Therefore, children and their caregivers should have proper education and training and understand the proper use of insulin pumps to achieve successful pump therapy. The pump therapy continuously improves to enhance its performance and increase its simulation of the human pancreas. Nonetheless, there is yet a long way to reach the desired goal. AIM To review discusses the history of pump development, its indications, types, proper use, special conditions that may enface the children and their families while using the pump, its general care, and its advantages and disadvantages. METHODS We conducted comprehensive literature searches of electronic databases until June 30, 2022, related to pump therapy in children and published in the English language. RESULTS We included 118 articles concerned with insulin pumps, 61 were reviews, systemic reviews, and meta-analyses, 47 were primary research studies with strong design, and ten were guidelines. CONCLUSION The insulin pump provides fewer needles and can provide very tiny insulin doses, a convenient and more flexible way to modify the needed insulin physiologically, like the human pancreas, and can offer adequate and optimal glycemic control to reduce the risk of metabolic derangements in different tissues.

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Section: Use Of the Insulin Pumpmentioning

confidence: 99%