Based on molecular docking to evaluate the protective effect of saponins from ginseng berry on D-gal-induced brain injury via multiple molecular mechanisms in mice

Liu, Yongbo; Sun, Da-zhong; Chen, Ke-cheng; Zhang, Junjie; Hou, Yun-yi; Gao, Xu-fei; Cai, Enbo; Zhu, Hongyan; Zheng, Yajuan; Chen, Rixin; Liu, Shuang; Li, Wei

doi:10.1016/j.jff.2022.105224

Cited by 4 publications

(2 citation statements)

References 44 publications

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“…Blunting Akt phosphorylation is closely associated with multiple neurodegenerative disease pathologies, including Aβ protein deposits, abnormal phosphorylation of tau protein, and neuroinflammation, 1–3 as well as neuronal atrophy. 32 Therefore, the hippocampus of EPEVLR-treated d -gal-induced mice was characterized. The hippocampus, an important regulator of learning and memory consolidation, can be divided into CA1, CA3, and DG regions.…”

Section: Resultsmentioning

confidence: 99%

Effects of an Akt-activating peptide obtained from walnut protein degradation on the prevention of memory impairment in mice

Lin,

Li,

Zhang

et al. 2024

Food Funct.

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Section: Resultsmentioning

confidence: 99%

Effects of an Akt-activating peptide obtained from walnut protein degradation on the prevention of memory impairment in mice

Lin,

Li,

Zhang

et al. 2024

Food Funct.

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“…Currently, liver damage has become a global health problem, causing a 30% mortality rate [ 3 ]. As an organ of oxygen consumption, the brain is vulnerable to free radical attacks, including oxygen, nitrogen, or metal radicals, resulting in Alzheimer’s disease, neurological disorders, chronic stress, and other related diseases [ 4 ]. The kidney is an important excretory organ that is responsible for the excretion of metabolic waste products, or toxins, in order to maintain a stable internal environment in the body [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Que Zui Tea on d-Galactose-Induced Oxidative Stress Damage in Mice via Regulating SIRT1/Nrf2 Signaling Pathway

Wang,

Zhao

et al. 2024

Molecules

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Que Zui tea (QT) is an important herbal tea in the diet of the ‘Yi’ people, an ethnic group in China, and it has shown significant antioxidant, anti-inflammatory, and hepatoprotective effects in vitro. This study aims to explore the protective effects of the aqueous-ethanol extract (QE) taken from QT against ᴅ-galactose (ᴅ-gal)-induced oxidative stress damage in mice and its potential mechanisms. QE was identified as UHPLC-HRMS/MS for its chemical composition and possible bioactive substances. Thus, QE is rich in phenolic and flavonoid compounds. Twelve compounds were identified, the main components of which were chlorogenic acid, quinic acid, and 6′-O-caffeoylarbutin. Histopathological and biochemical analysis revealed that QE significantly alleviated brain, liver, and kidney damage in ᴅ-gal-treated mice. Moreover, QE remarkably attenuated oxidative stress by activating the Nrf2/HO-1 pathway to increase the expression of antioxidant indexes, including GSH, GSH-Px, CAT, SOD, and T-AOC. In addition, QE administration could inhibit the IL-1β and IL-6 levels, which suppress the inflammatory response. QE could noticeably alleviate apoptosis by inhibiting the expressions of Caspase-3 and Bax proteins in the brains, livers, and kidneys of mice. The anti-apoptosis mechanism may be related to the upregulation of the SIRT1 protein and the downregulation of the p53 protein induced by QE in the brain, liver, and kidney tissues of mice. Molecular docking analysis demonstrated that the main components of QE, 6′-O-caffeoylarbutin, chlorogenic acid, quinic acid, and robustaside A, had good binding ability with Nrf2 and SIRT1 proteins. The present study indicated that QE could alleviate ᴅ-gal-induced brain, liver and kidney damage in mice by inhibiting the oxidative stress and cell apoptosis; additionally, the potential mechanism may be associated with the SIRT1/Nrf2 signaling pathway.

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Protective effects of seed oil from Nicotiana tabacum L. On D-galactose induced liver and brain damages of mice by regulating PI3K/Akt/Nrf2 signaling pathway

Gu,

Wang,

Xiao

et al. 2025

Journal of Functional Foods

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Based on molecular docking to evaluate the protective effect of saponins from ginseng berry on D-gal-induced brain injury via multiple molecular mechanisms in mice

Cited by 4 publications

References 44 publications

Effects of an Akt-activating peptide obtained from walnut protein degradation on the prevention of memory impairment in mice

Effects of an Akt-activating peptide obtained from walnut protein degradation on the prevention of memory impairment in mice

Protective Effect of Que Zui Tea on d-Galactose-Induced Oxidative Stress Damage in Mice via Regulating SIRT1/Nrf2 Signaling Pathway

Protective effects of seed oil from Nicotiana tabacum L. On D-galactose induced liver and brain damages of mice by regulating PI3K/Akt/Nrf2 signaling pathway

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