Baseline and phosphoramide mustard-induced sister-chromatid exchanges in pharmacists handling anti-cancer drugs

McDiarmid, Melissa A.; Kolodner, Ken; Humphrey, Frances; Putman, Donald L.; Jacobson‐Kram, David

doi:10.1016/0165-1218(92)90067-a

Cited by 24 publications

(12 citation statements)

References 20 publications

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“…Cancer patients are even known to develop subsequent tumors under such treatment (so-called ' 'drug-induced cancers"), while their cytogenetic tests show increase both in the number of chromosomal aberrations and in the sister chromatid exchange frequency [McDiarmid et al, 1992;Fuchs et al, 19951. Nevertheless, there is a growing number of papers dealing with health hazards related to occupational exposure to cytostatics [Sorsa et al, 1985;Cooke et al, 19911.…”

Section: Introductionmentioning

confidence: 99%

Work environment influence on cytostatics-induced genotoxicity in oncologic nurses

Brumen

Horvat

1996

Am. J. Ind. Med.

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The aim of the study was to point out the influence of workplace conditions on chromosomal damage incidence in nurses handling cytostatics. The study comprised two groups of 17 oncologic nurses each and the same number of matched controls. Sister chromatid exchange method (SCE) was used for genotoxicity assessment. In the group of nurses provided with a safe working environment, the SCE‐frequency was insignificantly increased when compared to the controls (p> 0.8), although wide SCE‐ranges were obtained. By contrast, in the group of nurses provided with neither such an environment nor with the appropriate personal protective equipment, the SCE‐frequency was significantly higher, not only compared to the controls (p< 0.001), but also to the first test group (p< 0.001). © 1996 Wiley‐Liss, Inc.

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Section: Introductionmentioning

confidence: 99%

Work environment influence on cytostatics-induced genotoxicity in oncologic nurses

Brumen

Horvat

1996

Am. J. Ind. Med.

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“…[47][48][49] Moreover, self-report of the duration of drug handling by pharmacists has been shown to be valid. 50 However, there is still potential for recall bias, since the pregnancy outcomes were reported on the same instrument that collected occupational exposures. Though we cannot directly measure recall bias, we do not believe it is likely to explain our findings.…”

Section: Commentmentioning

confidence: 99%

Occupational exposures among nurses and risk of spontaneous abortion

Lawson

Rocheleau

Whelan

et al. 2012

American Journal of Obstetrics and Gynecology

166

106

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Objective-We investigated self-reported occupational exposure to antineoplastic drugs, anesthetic gases, antiviral drugs, sterilizing agents (disinfectants), and X-rays and the risk of spontaneous abortion in U.S. nurses.Study Design-Pregnancy outcome and occupational exposures were collected retrospectively from 8,461 participants of the Nurses' Health Study II. Of these, 7,482 were eligible for analysis using logistic regression.Results-Participants reported 6,707 live births, and 775 (10%) spontaneous abortions (<20 weeks). After adjusting for age, parity, shift work, and hours worked, antineoplastic drug exposure was associated with a 2-fold increased risk of spontaneous abortion, particularly with early spontaneous abortion before the 12 th week, and 3.5-fold increased risk among nulliparous women. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Exposure to sterilizing agents was associated with a 2-fold increased risk of late spontaneous abortion (12-20 weeks), but not with early spontaneous abortion. HHS Public AccessConclusion-This study suggests that certain occupational exposures common to nurses are related to risks of spontaneous abortion.

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“…McDiarmid et al (1992) reported a positive correlation between the time of occupational exposure to antineoplastic drugs and the frequency of sister chromatid exchanges.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of occupational genotoxic risk in a Brazilian hospital

Maluf

Erdtmann

2000

Genet. Mol. Biol.

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Many therapeutic, diagnostic and prophylactic procedures used in hospitals are of potential genetic risk. An evaluation was made of genotoxic occupational risk in 42 workers from the Hospital de Clínicas de Porto Alegre, RS, Brazil, who had been occupationally exposed to lead (solder), ethylene oxide (sterilization area), antineoplastic drugs (nurses and pharmacists) or ionizing radiation. They were compared with 42 unexposed individuals. There was an increase in the frequency of binucleated cytochalasin-blocked lymphocytes with micronuclei, though it was not significant (P = 0.058). The groups exposed to antineoplastic drugs and radiation had a significant increase in micronuclei frequency (P = 0.038 and P = 0.022, respectively). The high frequencies of dicentric bridges suggest the action of clastogenics in these two groups. These results suggest that the safety procedures adopted were very important to protect workers from exposure to mutagenic agents and should be improved in the radiological and chemotherapeutical areas.

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Baseline and phosphoramide mustard-induced sister-chromatid exchanges in pharmacists handling anti-cancer drugs

Cited by 24 publications

References 20 publications

Work environment influence on cytostatics-induced genotoxicity in oncologic nurses

Work environment influence on cytostatics-induced genotoxicity in oncologic nurses

Occupational exposures among nurses and risk of spontaneous abortion

Evaluation of occupational genotoxic risk in a Brazilian hospital

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