Baseline Characteristics and Gender Differences in Prepubertal Children Treated with Growth Hormone in Europe, USA, and Japan: 25 Years' KIGS® Experience (1987-2012) and Review

Ranke, Michael B.; Lindberg, Anders; Tanaka, Toshiaki; Camacho‐Hübner, Cecilia; Geffner, Mitchell E.

doi:10.1159/000452887

Cited by 49 publications

(55 citation statements)

References 44 publications

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“…In the control, the statistical analysis revealed that they were divided into equal subgroups (50 % males and 50 % females). A similar result has also been observed by [19]. It has been noticed that more boys than girls are referred to endocrine clinics due to growth disturbances and that most cases of GHD among males are pituitary disorders;the function of the pituitary and particular the secretion of GH might be more susceptible in males than females.Also, short stature in girls is often not detected, or it is reported late [20].…”

Section: Results and Discussion Distribution Of The Studied Subjects supporting

confidence: 75%

Evaluation of Calcium Regulating Hormones and Some Biochemical Parameters in Growth Hormone Deficient Patients

Aldabagh

Al-Lami

Al-Samarriae

2020

eijs

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The present study aims to evaluate levels of calcium regulating hormones and some biochemical parameters in a sample of growth hormone (GH) deficient patients. Seventy five GH deficient patients and twenty healthy subjects used as a control group have been involved in this study during their attendance at the National Diabetic Centerfor Treatment and Research /Al-Mustansiriya University. The studied subjects were in an age range of 3-15 years. Blood samples were collected from the studied subjects to determine levels of basal GH,GH 2. and GH 3 after 60 mins. and 90mins. of provocation with clonidine. The study also included the measurement of the levels of insulin like growth factor (IGF-1); calcium regulating hormones [parathyroid hormone (PTH) and vitamin D],and some biochemical parameters [calcium (Ca), phosphorus (P), urea, and creatinine].Distribution of the studied groups according to gender revealed that most of the GH deficientpatients (60 %) were males while 40 % were females,with the difference being statistically significant (P<0.05), while the control included two equal subgroups (50 % males and 50 % females). Distribution of the studied groups according to BMI values showed that the percentage of underweight was significantly (P<0.01) higher in the patients (48%) compared to the control (10%), while the percentage of normal weight was significantly (P<0.01) higher in the control (85%) as compared to the patients (40%).The results showed highly significant decreases (P<0.01) in the levels of basal GH, GH 2 and GH 3 in the patients as compared to the control group. Also, IGF-1 levels showed a high significant (P<0.01) decrease in the patients as compared to the control group.The findings of calcium regulating hormones revealed non-significant differences in the levels of PTH and vitamin D between the patients and the control group. Also, the results of the biochemical parameters (Ca, P, urea, and creatinine) showed non-significant differences in their values between the patients and the control group.It can be concluded from the present study that GH deficiency (GHD) seems to be dominating in the males under weighted patients. The diagnosis of GHD cannot be achieved at the basal GH level.IGF-1 is a reliable marker of GH functions. Finally, levels of calcium regulating hormones are not affected by GHD.

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Section: Results and Discussion Distribution Of The Studied Subjects supporting

confidence: 75%

Evaluation of Calcium Regulating Hormones and Some Biochemical Parameters in Growth Hormone Deficient Patients

Aldabagh

Al-Lami

Al-Samarriae

2020

eijs

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“…At the start of rhGH, girls with NS tend to be younger and smaller, which may be the results of a bias of inclusion also suspected in other growth disorders treated with GH [33]. The observation that the difference in height SDS between the sexes is significant only when normal references are used, but not if NS specific references are applied, is remarkable.…”

Section: Discussionmentioning

confidence: 99%

Treatment with Growth Hormone in Noonan Syndrome Observed during 25 Years of KIGS: Near Adult Height and Outcome Prediction

et al. 2019

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Background/Aims: There is little information how rhGH treatment affects height in NS. This study aims to analyze data from the NS patients assembled in KIGS over 25 years. Patients/Methods: Of 613 (389 m/224 f) NS patients documented, 476 (302 m/174 f) were treated for 1 year, 237 (160 m/77 f) of which served to develop a 1st year height velocity (HV) prediction algorithm. One-hundred and forty (74 m/66 f) had reached near adult height (NAH). Factors affecting NAH on rhGH were determined. Results: At the start of rhGH, the NAH groups were (median, m, f) 11.0 and 10.3 years, with a height SDS of –3.2 and –3.8 SDS (Prader), respectively. The total gain after 6.3 and 5.6 years on rhGH (0.27 and 0.30 mg/kg/week) was 1.2 and 1.3 SDS. Age at the start of rhGH (negative), height at the start of rhGH, rhGH dose, number of rhGH injections/wk and birth weight (all positive) explained 36% of the variability of 1st year HV. Height at the start of rhGH, 1st year growth on rhGH, birth weight, and gender explained 74% of the variability of NAH. Causes for rhGH treatment discontinuation and adverse events were also analyzed. Conclusion: rhGH treatment increases NAH in NS. Prediction algorithms may optimize treatment in the future.

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“…Although the GH response in ISS is well-known, responsiveness varies among individuals diagnosed with ISS. There have been many attempts at developing GH prediction models calculated based on the available information (Wikland et al 2000;Ranke et al 2017). Bakker et al (2008) evaluated GH response among good responders and poor responders according to HV and Δheight SDS using data from the National Cooperative Growth Study.…”

Section: Discussionmentioning

confidence: 99%

Idiopathic Short Stature Phenotypes among Korean Children: Cluster Analysis

Nam

Kim

Lee

et al. 2019

Tohoku J. Exp. Med.

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Idiopathic short stature (ISS) is a heterogeneous group and their responsiveness to growth hormone treatment varies among individuals. The aim of this study was to identify homogeneous phenotypes to better assess response before the initiation of treatment. We focused on person-centered approaches using a latent profile analysis. Clinical data of 218 children (127 boys and 91 girls) aged 4-15 years were obtained from the "LG Growth Study" which is a non-interventional Korean multicenter registry for growth hormone treatment. Growth hormone dose, first-year difference in height standard deviation score (Δheight SDS), mid-parental height SDS, and initial bone age were inputted into the model. The distribution of scatter plot was clearly distinguished at the chronological age of 8.83 years, Δheight SDS of 0.82 and mean GH dose of 0.36 mg/kg/week. The latent profile analysis revealed three distinct phenotypes names as follows: younger good responder (n = 56), older good responder (n = 111), and older poor responder (n = 51) groups. Despite more than twice the mean growth hormone dose, the older poor responder group showed the least improvement in the mean Δheight SDS. The pretreatment height velocity and peak growth hormone level were lower for the older poor responder group compared with those of the older good responder group. The statistically optimal cutoff point for predicting poor response was 3.41 cm/year for pretreatment height velocity and 9.18 ng/mL for peak growth hormone level. This study offers a new multidimensional approach to enable personalized growth hormone treatment optimization according to ISS phenotypes.

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Baseline Characteristics and Gender Differences in Prepubertal Children Treated with Growth Hormone in Europe, USA, and Japan: 25 Years' KIGS® Experience (1987-2012) and Review

Cited by 49 publications

References 44 publications

Evaluation of Calcium Regulating Hormones and Some Biochemical Parameters in Growth Hormone Deficient Patients

Evaluation of Calcium Regulating Hormones and Some Biochemical Parameters in Growth Hormone Deficient Patients

Treatment with Growth Hormone in Noonan Syndrome Observed during 25 Years of KIGS: Near Adult Height and Outcome Prediction

Idiopathic Short Stature Phenotypes among Korean Children: Cluster Analysis

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