Baseline characteristics in stroke patients with atrial fibrillation: clinical trials versus clinical practice

Tanislav, Christian; Milde, Sonja; Schwartzkopff, Sabine; Misselwitz, Björn; Sieweke, Nicole; Kaps, Manfred

doi:10.1186/s13104-015-1237-2

Cited by 18 publications

(4 citation statements)

References 24 publications

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“…Moreover, real-world fragile patients might have been included (e.g., patients with increased risk of bleeding, liver disease, and chronic kidney disease), although these patients would be less represented in the trials. 10) This paper highlights recently published real-world data of NOACs and further recommends NOAC dosages for Korean patients.…”

Section: Introductionmentioning

confidence: 93%

Real-world Data and Recommended Dosage of Non-vitamin K Oral Anticoagulants for Korean Patients

Joung

2017

Korean Circ J

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Regulatory approvals of non-vitamin K antagonist oral anticoagulants (NOACs) have been based on large randomized phase III trials evaluating dabigatran, rivaroxaban, apixaban, or edoxaban relative to warfarin for atrial fibrillation (AF). The results of the trials showed that all NOACs were at least non-inferior to warfarin in the prevention of stroke/thromboembolism and showed lower rates of intracranial bleeding than those associated with warfarin. However, the trials were designed differently, varied in the inclusion/exclusion criteria, and used either one dose or a low/high dose of the NOAC drug. Some of these differences have challenged the ability to directly compare various NOACs, and comparative data on effectiveness and intracranial bleeding are sparse in “real-world” patients. Real-world data complement data from large randomized phase III trials by providing new aspects of the “real-world” absolute risks of ischemic and hemorrhagic stroke associated with NOACs vs. warfarin. Moreover, “real-world” fragile patients might have been included (e.g., patients with increased risk of bleeding, liver disease, and chronic kidney disease), although these patients would be less represented in trials. This paper introduces recently published real-world data of NOACs and further suggests the recommended dosage of NOACs for Korean patients.

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Section: Introductionmentioning

confidence: 93%

Real-world Data and Recommended Dosage of Non-vitamin K Oral Anticoagulants for Korean Patients

Joung

2017

Korean Circ J

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“…Christian Tanislav et al reported the higher mean age and overrepresentation of male sex in the baseline characteristics of stroke patients [39]. In a study conducted by Ginenus Fekadu et al, the number of males found to be higher consisted of 62.9% among the overall stroke patients [40].…”

Section: Discussionmentioning

confidence: 97%

Evaluation of ECG Features for the Classification of Post-Stroke Survivors with a Diagnostic Approach

2020

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Stroke is considered as a major cause of death and neurological disorders commonly associated with elderly people. Electrocardiogram (ECG) signals are used as a powerful tool in diagnosing stroke, and the analysis of ECG signals has become the focus of stroke research. ECG changes and autonomic dysfunction are reportedly seen in patients with stroke. This study aimed to analyze the ECG features and develop a classification model with highly ranked ECG features as input variables based on machine-learning techniques for diagnosing stroke disease. The study included 52 stroke patients (mean age 72.7 years, 63% male) and 80 control subjects (mean age 75.5 years, 39% male) for a total of 132 elderly subjects. Resting ECG signals in the lying down position are measured using the BIOPAC MP150 system. The ECG signals are denoised using the discrete wavelet transform (DWT) method, and the features such as heart rate variability (HRV), indices of time and spectral domains and statistical and impulsive metrics, in addition to fiducial features, are extracted and analyzed. Our results showed that the values of the HRV variables were lower in the stroke group, revealing autonomic dysfunction in stroke patients. A statistically significant difference was observed in low-frequency (LF)/high-frequency (HF), time interval measured after the S wave to the beginning of the T wave (ST) and time interval measured from the beginning of the Q wave to the end of the T wave (QT) (p < 0.05) between the groups. Our study also highlighted some of the risk factors of stroke, such as age, male sex and dyslipidemia (p < 0.05), that are statistically significant. The k-nearest neighbors (KNN) model showed the highest classification results (accuracy 96.6%, precision 94.3%, recall 99.1% and F1-score 96.6%) than the random forest, support vector machine (SVM), Naïve Bayes and logistic regression models. Thus, our study reported some of the notable ECG changes in the study participants and also indicated that ECG could aid in diagnosing stroke disease.

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“…Связь между АГ и ФП -двунаправленная [18]. Недавние клинические исследования показали, что у лиц с ФП в 70,7-85,0% случаев регистрируется АГ [18][19][20]. По данным российского регистра РЕКВАЗА, 90,5% лиц с ФП имеют АГ [21].…”

Section: эпидемиологияunclassified

Management of patients with arterial hypertension and atrial fibrillation

Чазова¹,

Голицын²,

Zhernakova³

et al. 2021

System. Hyper.

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Arterial hypertension (AH) is a leading risk factor for cardiovascular disease as well as it is the most common, independent and potentially reversible risk factor for atrial fibrillation (AF). AH contributes to the occurrence and maintenance of AF due to hemodynamic disorders, alterations in cardiomyocyte electrophysiological properties and structural remodeling in the atria. AF, which is also associated with an increased risk of cardiovascular events, is the most common arrhythmia. AH and AF often coexist, and their prevalence increases with age. This consensus provides the key features of the management of patients with these nosological units. The pathogenesis, risk stratification, and features of the selection of antihypertensive, antiarrhythmic and antithrombotic therapy are described in detail.

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Baseline characteristics in stroke patients with atrial fibrillation: clinical trials versus clinical practice

Cited by 18 publications

References 24 publications

Real-world Data and Recommended Dosage of Non-vitamin K Oral Anticoagulants for Korean Patients

Real-world Data and Recommended Dosage of Non-vitamin K Oral Anticoagulants for Korean Patients

Evaluation of ECG Features for the Classification of Post-Stroke Survivors with a Diagnostic Approach

Management of patients with arterial hypertension and atrial fibrillation

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