Baseline comprehensive geriatric assessment is associated with toxicity and survival in elderly metastatic breast cancer patients receiving single-agent chemotherapy: Results from the OMEGA study of the Dutch Breast Cancer Trialists' Group

Hamaker, Marije E.; Seynaeve, Caroline; Wymenga, A.N.M.; Tinteren, Harm van; Nortier, J.W.R.; Maartense, E.; Graaf, Hiltje de; Jongh, Felix E. de; Braun, J. J.; Los, Maartje; Schrama, J. G.; Leeuwen-Stok, A. Elise van; Groot, S.M. de; Smorenburg, Carolien H.

doi:10.1016/j.breast.2013.11.004

Cited by 127 publications

(90 citation statements)

References 39 publications

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“…Among ambulatory older cancer patients, reported rates of polypharmacy (defined as ≥ 5 prescription medications) ranges from 50% to 80% [22, 23, 30, 39, 40]. In an older inpatient cancer population, approximately one-third of patients were prescribed ≥ 9 medications prior to admission [21].…”

Section: Discussionmentioning

confidence: 99%

The prognostic importance of polypharmacy in older adults treated for acute myelogenous leukemia (AML)

et al. 2014

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We retrospectively evaluated the prognostic significance of polypharmacy and inappropriate medication use among 150 patients >60 years of age receiving induction chemotherapy for acute myelogenous leukemia (AML). After adjustment for age and comorbidity, increased number of medications at diagnosis (≥4 vs. ≤1) was associated with increased 30-day mortality (OR=9.98, 95% CI=1.18–84.13), lower odds of complete remission status (OR=0.20, 95% CI=0.06–0.65), and higher overall mortality (HR=2.13, 95% CI=1.15–3.92). Inappropriate medication use (classified according to Beers criteria) was not significantly associated with clinical outcomes. Polypharmacy warrants further study as a modifiable marker of vulnerability among older adults with AML.

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Section: Discussionmentioning

confidence: 99%

The prognostic importance of polypharmacy in older adults treated for acute myelogenous leukemia (AML)

et al. 2014

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“…A GA is defined as a multidimensional, interdisciplinary diagnostic process focusing on determining an older person's medical, psychosocial, and functional capabilities to develop a coordinated and integrated plan for treatment and long-term follow-up (10). Such a GA has been shown to successfully identify patients at risk for poor outcome in geriatric oncology (11) and improve outcomes in older patients admitted to the emergency department (9), and it is increasingly recommended as being the standard of care in the treatment decisionmaking process in elderly patients (8). The aim of this review is to give an overview of all currently available evidence regarding the relation of geriatric impairments and the accumulation of impairment across these domains at initiation of dialysis with mortality and dialysis-related complications.…”

Section: Introductionmentioning

confidence: 99%

The Relevance of Geriatric Impairments in Patients Starting Dialysis: A Systematic Review

Loon

Wouters²,

Boereboom

et al. 2016

CJASN

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Background and objectives With aging of the general population, patients who enter dialysis therapy will more frequently have geriatric impairments and a considerable comorbidity burden. The most vulnerable among these patients might benefit from conservative therapy. Whether assessment of geriatric impairments would contribute to the decision-making process of dialysis initiation is unknown.Design, setting, participants, & measurements A systematic Medline and Embase search was performed on December 1, 2015 to identify studies assessing the association between risk of mortality or hospitalization and one or more geriatric impairments at the start of dialysis therapy, including impairment of cognitive function, mood, performance status or (instrumental) activities of daily living, mobility (including falls), social environment, or nutritional status.Results Twenty-seven studies were identified that assessed one or more geriatric impairments with respect to prognosis. The quality of most studies was moderate. Only seven studies carried out an analysis of elderly patients ($70 years old). Malnutrition and frailty were systematically assessed, and their relation with mortality was clear. In addition, cognitive impairment and functional outcomes at the initiation of dialysis were related to an increased mortality in most studies. However, not all studies applied systematic assessment tools, thereby potentially missing relevant impairment. None of the studies applied a geriatric assessment across multiple domains.Conclusions Geriatric impairment across multiple domains at dialysis initiation is related to poor outcome. However, information in the elderly is sparse, and a systematic approach of multiple domains with respect to poor outcome has not been performed. Because a geriatric assessment has proved useful in predicting outcome in other medical fields, its potential role in the ESRD population should be the subject of future research.

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“…Todos los artículos estaban redactados en inglés. El año con mayor número de artículos fue 2014 con tres publicaciones (75%) (11)(12)(13).…”

Section: Resultsunclassified

“…Otro artículo asesoró para aumentar la ingesta 600 kcal/día a un grupo, a un segundo grupo le proporcionó un suplemento nutricional de 588 Kcal/día junto con vitaminas y minerales y a un tercer grupo se le dio consejo dietético para aumentar la ingesta 600 kcal/día además de vitaminas y minerales (14). En uno de los trabajos no constaba intervención nutricional específica (11).…”

Section: Eortc-c30 Y Faactunclassified

Evaluación de la calidad de vida según el estado nutricional del paciente paliativo adulto: revisión sistemática

Aracil-Lavado

Wanden-Berghe²,

Sanz-Valero³

2017

Hosp Domic

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Conflicto de Intereses/Competing interestLas autoras y el autor declaran la no existencia de ningún tipo de conflicto de interés cómo citar este trabajo | how to cite this paper Aracil-Lavado E, Wanden-Berghe C, Sanz-Valero J. Evaluación de la calidad de vida según el estado nutricional del paciente paliativo adulto: revisión sistemática. Hosp Domic. 2017;1(4):199-210 Evaluación de la calidad de vida según el estado nutricional del paciente paliativo adulto: revisión sistemática Evaluation of quality of life according to the nutritional status of the adult palliative patient: systematic review

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Baseline comprehensive geriatric assessment is associated with toxicity and survival in elderly metastatic breast cancer patients receiving single-agent chemotherapy: Results from the OMEGA study of the Dutch Breast Cancer Trialists' Group

Cited by 127 publications

References 39 publications

The prognostic importance of polypharmacy in older adults treated for acute myelogenous leukemia (AML)

The prognostic importance of polypharmacy in older adults treated for acute myelogenous leukemia (AML)

The Relevance of Geriatric Impairments in Patients Starting Dialysis: A Systematic Review

Evaluación de la calidad de vida según el estado nutricional del paciente paliativo adulto: revisión sistemática

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